Interleukin 18 promoter polymorphisms are not strongly associated with type I diabetes in a UK population

Martin, Rosalind; Savage, David A.; Carson, Dennis; Maxwell, Alexander P.; Patterson, Christopher

doi:10.1038/sj.gene.6364161

Cited by 16 publications

(9 citation statements)

References 23 publications

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“…The observed genotype frequencies were in accordance with Hardy-Weinberg equilibrium. The allele distribution and haplotypes of the control group were previously published [26] and were similar to other reports on Caucasian populations [27]. We found no association of IL-18 -137 or -607 polymorphism with age (p ϭ 0.085 and p ϭ 0.873, respectively) or gender (p ϭ 0.310 and p ϭ 0.530, respectively).…”

Section: Il-18 Genotypes and Cancer Risksupporting

confidence: 88%

Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients

Sáenz-López¹,

Carretero²,

Vázquez³

et al. 2010

Human Immunology

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Section: Il-18 Genotypes and Cancer Risksupporting

confidence: 88%

Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients

Sáenz-López¹,

Carretero²,

Vázquez³

et al. 2010

Human Immunology

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“…Ide et al (22) found that a higher promoter activity of haplotype -137G/-607C of the IL-18 gene might increase the expression of IL-18, resulting in upregulation of the IFN-γ-producing T-cells. It is reported that the two loci (-137 C/G, -607 A/C) were in LD (19,24). Lastly, clinical heterogeneity might also explain the discrepancy.…”

Section: Discussionmentioning

confidence: 85%

“…The potential contribution of differences in patient populations (e.g., age and years from onset, as well as disease severity) might lead to different results. In the study by Martin et al (24), the age at diagnosis of cases was under 15 years, whereas in the Polish and Japanese studies the age at diagnosis was under 30 years.…”

Section: Discussionmentioning

confidence: 96%

Association of the interleukin-18 −137 C/G, −607 A/C polymorphisms with type 1 diabetes: A meta-analysis

Wang

et al. 2013

Biomedical Reports

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Abstract. Published data on the association between interleukin (IL)-18 gene polymorphisms (-137 C/G, -607 A/C) and type 1 diabetes (T1D) risk are inconclusive. To obtain a more precise estimation of the association between the IL-18 gene polymorphisms and T1D, a meta-analysis was performed. A total of 11 studies including 5,945 cases and 6,404 controls were included in the analysis of the association between -137 C/G and T1D risk. No significant association between -137 C/G and T1D risk was observed in the total population [C vs. G: odds ratio (OR)=1.02, 95% confidence interval (CI)=0.87-1.20; CC + CG vs. GG: OR=1.05, 95% CI=0.87-1.25; CC vs. CG + GG: OR= 0.96, 95% CI= 0.68-1.36]. No significant association was identified in the stratified analysis for all the genetic models in the European population. Concerning -607 A/C, 10 studies involving 3,048 patients and 3,377 controls were included in this meta-analysis. When all the studies were pooled, the results showed no evidence for a significant association between IL-18 -607 A/C polymorphism and T1D risk (A vs. C: OR=0.93, 95% CI=0.81-1.06; AA + AC vs. CC: OR=0.99, 95% CI=0.89-1.10; AA vs. AC + CC: OR=0.81, 95% CI=0.60-1.09). In addition, similar results were obtained in the subgroup analysis based on ethnicity. In summary, the present meta-analysis suggests a lack of association between the two polymorphisms (-137 C/G, -607 A/C) in the IL-18 gene and T1D. Due to the limitation of the number of the studies, the conclusions drawn should be considered with caution. Larger scale primary studies are required to evaluate the association between IL-18 gene polymorphisms and T1D.

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“…The IL-18 C-607A SNP is a common polymorphism with allele frequencies that are dependent on ethnic background. For example, in Han Chinese, the frequency of the A allele is 51.3-53.0% (Dong et al 2007;Yu et al 2009;Zhang et al 2005), whereas in British Caucasians the A allele is less frequent, 35.7-40.8% (Gracie et al 2005;Martin et al 2005). In this study, distributions of the IL-18 C-607A SNP were determined and compared in healthy Singaporean Chinese, Indians, and Malays.…”

Section: Introductionmentioning

confidence: 98%

Hardy–Weinberg Disequilibrium of the IL-18 C−607A SNP Suggesting Selective Advantage of Heterozygotes

Chen

Gan

2011

Biochem Genet

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Interleukin-18 (IL-18) plays a key role in autoimmune, inflammatory, and infectious diseases. The IL-18 gene contains a C to A single nucleotide polymorphism (SNP) at position -607 (C-607A) within the promoter region, which was found to affect the promoter activity and subsequently the protein level of IL-18. We investigated this SNP in a group of healthy Singaporeans and found that CA was the most common genotype and the C allele was more prevalent than the A allele, which was not always the case in other ethnic groups. In addition, Singaporean Chinese were significantly different from Singaporean Indians in both allelic and genotypic distributions. Furthermore, significant deviations from Hardy-Weinberg equilibrium of this SNP were found in all three ethnic groups studied (Chinese, Indians, and Malays) and also in other published literature, suggesting that heterozygotes of this IL-18 C-607A SNP may have certain selective advantages.

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Interleukin 18 promoter polymorphisms are not strongly associated with type I diabetes in a UK population

Cited by 16 publications

References 23 publications

Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients

Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients

Association of the interleukin-18 −137 C/G, −607 A/C polymorphisms with type 1 diabetes: A meta-analysis

Hardy–Weinberg Disequilibrium of the IL-18 C−607A SNP Suggesting Selective Advantage of Heterozygotes

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