Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients

Sáenz-López, Pablo; Carretero, Rafael; Vázquez, Fernando; Martín, Javier; Sánchez, Elena; Tallada, M; Garrido, Federico; Cózar, J.M.; Ruiz‐Cabello, Francisco

doi:10.1016/j.humimm.2009.11.010

Cited by 28 publications

(24 citation statements)

References 35 publications

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“…The genotyping of the polymorphisms was performed using predesigned TaqMan SNP Genotyping Assays (Applied Biosystems, Foster City, CA). Amplification assays and reaction conditions were described previously [11]. The following single-nucleotide polymorphisms were typed: NOD2 A/G rs9302752, RIPK2 A/T rs42490, C13ORF31 C/T rs3764147 and TLR10 C/T rs4129009 and T/G rs11096955.…”

Section: Dna Extraction and Genotypingmentioning

confidence: 99%

“…Numerous mediators in dysregulated chronic inflammation have been found to induce mutagenesis and increase angiogenicity, promoting cell growth and invasion [8]. Polymorphisms in cytokine genes have been associated with risk and clinical-pathoplogical characteristic of various tumor diseases, including bladder [9], prostate and renal cancers [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer

et al. 2012

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Section: Dna Extraction and Genotypingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer

et al. 2012

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“…Using these terms, a total of 35 articles were retrieved, of which 17 [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] articles according to the inclusion criteria reported on studies examining the association between IL-18 -607(C/A) or -137(G/C) polymorphism and cancer risk.…”

Section: Publication Searchmentioning

confidence: 99%

“…The functional significance of these two SNPs has been shown that the C allele at position -607 and the G allele at position -137 were attributed to the IL-18 higher transcription and protein production [11,12]. These two SNPs have been investigated in several types of cancer such as renal cell carcinoma [13], ovarian cancer [14,28], breast cancer [15], nasopharyngeal carcinoma [16,20,22], cervical cancer [17,29], esophageal squamous cell carcinoma [18], prostate cancer [19], lung cancer [21], stomach cancer [23], colorectal cancer [23,25], head and neck squamous cell carcinoma [24], oral cancer [26] and lymphomas [27].…”

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confidence: 99%

Review and pooled analysis of studies on -607(C/A) and -137(G/C) polymorphisms in IL-18 and cancer risk

et al. 2010

Med Oncol

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Interleukin-18 (IL-18) is a pleiotropic, pro-inflammatory cytokine with dual effects on tumor development and progression. The -607(C/A) and -137(G/C) polymorphisms in IL-18 gene region have been implicated in cancer risk; however, data from published studies with individually low statistical power are conflicting. To clarify the role of IL-18 -607(C/A) and -137(G/C) genotype in global cancer, we examined all the available published studies through a pooled analysis approach. Overall, IL-18 -607A allele was associated with increased total cancer risk when compared with -607C allele (OR=1.14, 95% CI=1.01-1.28, P=0.010), as well as in the heterozygote comparison (OR=1.10, 95% CI=1.04-1.15, P=0.256) and the dominant model (OR=1.07, 95% CI=1.03-1.11, P=0.124). Furthermore, IL-18 -137(G/C) polymorphism was associated with increased nasopharyngeal carcinoma risk. In the stratified analysis for -607(C/A) polymorphism, a significantly increased cancer risk in Asian population was found, as well as subgroup in source of control. Similar results were found in the stratified analysis for -137(G/C) polymorphism. Our pooled analysis supported that IL-18 is a good candidate for large-scale epidemiological case-control studies that may be a low-penetrance susceptibility biomarker for cancer.

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“…Additionally, increased levels of IL-8 in proliferative diabetic retinopathy were reported to be associated with a higher extent of large-vessel gliotic obliteration [20]. The tested polymorphisms of IL-8 and IL-18 (1633T/C, 251A/T, 607C/A, 137G/C) have recently been reported to be associated with various forms of cancer [20][21][22][23][24][25]. Moreover, the -607C/A and the -137G/C polymorphisms of the IL-18 gene were reported to be associated with susceptibility to type 1 diabetes; the C allele of-137 polymorphism was found to be a risk allele for DR and the A allele of -607 was found to be a protective allele against DR [14].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of interleukin-8 and -18 genes and diabetic retinopathy

et al. 2010

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Abstract:We evaluated possible roles of interleukin-8 gene polymorphisms (1633T/C-rs2227543, 251A/T-rs4073) and interleukin-18 gene polymorphisms (-607C/A-rs1946518, -137G/C-rs187238) in the development of diabetic retinopathy (DR) in Caucasians with type 2 diabetes. 271 patients with DR and 113 without diabetic retinopathy were enrolled in this cross-sectional study. We did not observe an association between either interleukin-8 gene polymorphisms (1633T/C, 251A/T) or interleukin-18 gene polymorphisms (-607C/A, -137G/C) and diabetic retinopathy in Caucasians with type 2 diabetes. We did not find statistically significant differences in interleukin-8 serum levels between diabetics with the TT and AA genotype and those with other genotypes. The interleukin-18 serum levels between diabetics with the CC genotype of the -607C/A polymorphism and those with other genotypes (AA, AC) were not significantly different. Moreover, we did not observe a statistically significant effect of the tested polymorphisms of either interleukin-8 or interleukin-18 genes on serum levels in diabetics. In conclusion, our study indicates that the examined polymorphisms of interleukin-8 (1633T/C, 251A/T) and interleukin-18 (-607C/A or the -137G/C) genes are not genetic risk factors for diabetic retinopathy. Therefore, they may not be used as genetic markers for diabetic retinopathy in Caucasians with type 2 diabetes.© Versita Sp. z o.o.

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Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients

Cited by 28 publications

References 35 publications

Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer

Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer

Review and pooled analysis of studies on -607(C/A) and -137(G/C) polymorphisms in IL-18 and cancer risk

Polymorphisms of interleukin-8 and -18 genes and diabetic retinopathy

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