Association of the interleukin-18 −137 C/G, −607 A/C polymorphisms with type 1 diabetes: A meta-analysis

Abstract

Abstract. Published data on the association between interleukin (IL)-18 gene polymorphisms (-137 C/G, -607 A/C) and type 1 diabetes (T1D) risk are inconclusive. To obtain a more precise estimation of the association between the IL-18 gene polymorphisms and T1D, a meta-analysis was performed. A total of 11 studies including 5,945 cases and 6,404 controls were included in the analysis of the association between -137 C/G and T1D risk. No significant association between -137 C/G and T1D risk was observed in the total population [C vs. G: odds ratio (OR)=1.02, 95% confidence interval (CI)=0.87-1.20; CC + CG vs. GG: OR=1.05, 95% CI=0.87-1.25; CC vs. CG + GG: OR= 0.96, 95% CI= 0.68-1.36]. No significant association was identified in the stratified analysis for all the genetic models in the European population. Concerning -607 A/C, 10 studies involving 3,048 patients and 3,377 controls were included in this meta-analysis. When all the studies were pooled, the results showed no evidence for a significant association between IL-18 -607 A/C polymorphism and T1D risk (A vs. C: OR=0.93, 95% CI=0.81-1.06; AA + AC vs. CC: OR=0.99, 95% CI=0.89-1.10; AA vs. AC + CC: OR=0.81, 95% CI=0.60-1.09). In addition, similar results were obtained in the subgroup analysis based on ethnicity. In summary, the present meta-analysis suggests a lack of association between the two polymorphisms (-137 C/G, -607 A/C) in the IL-18 gene and T1D. Due to the limitation of the number of the studies, the conclusions drawn should be considered with caution. Larger scale primary studies are required to evaluate the association between IL-18 gene polymorphisms and T1D.

IL16 and IL18 gene polymorphisms in women with gestational diabetes

“…Fatima et al found that increased IL18 levels in women with GDM were correlated with low-grade inflammation and insulin resistance [26]. IL18 gene polymorphisms have been investigated among patients with type 1 and type 2 diabetes [27][28][29][30][31]. Several studies suggest that these polymorphisms may be associated with an increased risk of diabetes and its cardiovascular complications.…”

Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment

“…A deficiency in NCC on β cells or IL-18R in acinar cells reduces β cell proliferation and islet size with a concomitant rise in β cell apoptosis and exocrine macrophage accumulation ( 146 ). T1D is possibly a Th1 cell-mediated disease ( 147 ) that affects millions of people around the world and its etiology is complex with a combination of genetic and environmental pathogenic factors ( 148 , 149 ). Although the Human leukocyte antigen (HLA) genes are known to have a role in the development of T1D, evidence have continued to indicate that the pro-inflammatory IL-18 contributes to the genetic susceptibility to T1D ( 150 ).…”

Does product touch affect consumer attitude toward a product? Meta‐analysis of effect sizes, moderators, and mediators

“…As shown in Table 2, the product type did not moderate the effect of product touch on consumer attitude ($${Q}_{B}$$ = 0.482, p = 0.487). However, past research suggested that researchers could still compare the effect sizes between conditions when the difference between groups was insignificant (Li, 2013; Maity et al, 2014). Further group‐wise comparisons showed that, for utilitarian products, the effect size between product touch and consumer attitude was positive and significant ($$\rho $$ = 0.259, p < 0.001).…”