Interleukin-1-Polymorphismen im Zusammenhang mit externen apikalen Wurzelresorptionen (EAWR)

Abstract

The available data of the IL-1A polymorphism point to an association of the genotype 2-2 with EARR. As analyses of individual subgroups showed, with the increase in the extent of EARR there was a recognizable correlation with genotype 2-2. The genotype distribution of the IL-1B polymorphism in patients and control cohorts revealed no indication of a predisposition. Despite the low number of cases in the own cohort, the data collected revealed that the allele 1 of the IL-1B polymorphism in patients with sporadic EARR did not contribute to predisposition, in contrast to familial cases. The results are an initial basis for pre-orthodontic genetic EARR risk analyses.

Association of genetic polymorphism and external apical root resorption

“…The results of the present review suggest that although some authors have reported that genetic polymorphism may play a role in EARR, [4][5][6][7][8][9][20][21][22][23]24 others have not supported this association. [25][26] Published orthodontic investigations in gene studies have seldom adhered to the STREGA or any genetic guidelines.…”

Severe external apical root resorption—local cause or genetic predisposition?

“…menhang mit der Entstehung von schwergradigen Wurzelresorptionen bei kieferorthopädischer Behandlung stehen sollen: IL-1A (Interleukin-1α), IL-1B (Interleukin-1β), TNFα (Tumornekrosefaktor-α), TNFRSF11A (receptor activator of nuclear factor-kappa B (RANK)) und TNSALP (non-specific alkaline phosphatase) [2,3,4,17,20,61]. Bisher gelang es Gülden et al [17] für IL-1A sowie Al-Qawasmi et al [2] und Bastos et al [6] für IL-1B Polymorphismen zu identifizieren, die gehäuft im jeweils untersuchten Patientengut mit externen apikalen WR vorkamen. Nach Al-Qawasmi et al [2] ist eine Mutation von IL-1B für 15% der Variabilität der WR an OK-Inzisivi verantwortlich und Personen, die homozygot für dieses Allel sind, haben ein 5,6fach erhöhtes Risiko einer WR von mehr als 2 mm im Vergleich zu den Heterozygoten.…”

“…Harris et al [19] estimated that the proportion of the hereditary component is 60% -80% for external apical RR in patients undergoing orthodontic treatment. Animal and human studies have proposed various candidate genes potentially directly linked to the development of severe root resorption: IL-1A (interleukin-1α), IL-1B (interleukin-1β), TNF-α (tumor necrosis factor-α), TNFRSF11A [receptor activator of nuclear factor-kappa B (RANK)] and TNSALP (non-specific alkaline phosphatase) [2,3,4,17,20,61]. Polymorphisms linked to external apical RR in specific patient groups were identified by Gülden et al [17] for IL-1A and by Al-Qawasmi et al [2] and Bastos et al [6] for IL-1B.…”

“…Animal and human studies have proposed various candidate genes potentially directly linked to the development of severe root resorption: IL-1A (interleukin-1α), IL-1B (interleukin-1β), TNF-α (tumor necrosis factor-α), TNFRSF11A [receptor activator of nuclear factor-kappa B (RANK)] and TNSALP (non-specific alkaline phosphatase) [2,3,4,17,20,61]. Polymorphisms linked to external apical RR in specific patient groups were identified by Gülden et al [17] for IL-1A and by Al-Qawasmi et al [2] and Bastos et al [6] for IL-1B. According to Al-Qawasmi et al [2], an IL-1B mutation is responsible for 15% of RR's variability in maxillary incisors; persons Schlüsselwörter Apikale Wurzelresorption · EARR · Inzisiven · Tip-Edge® · Multibracket-Behandlung · Orthopantomogramm Einleitung Wurzelresorptionen (WR) stehen als unerwünschte kieferorthopädische Nebenwirkung im Mittelpunkt vieler Diskussionen.…”

Interleukin-1β +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: A meta-analysis

“…Over the last decade, a number of case-control studies (Al-Qawasmi et al, 2003a;Bastos Lages et al, 2009;Gülden et al, 2009;Tomoyasu, 2009;Iglesias-Linares, 2012a,b;Linhartova, 2012) have been conducted to investigate the association between the IL-1β +3954 C>T polymorphism and EARR risk in orthodontic treatment patients. However, the results of these studies are conflicting.…”