Association of genetic polymorphism and external apical root resorption

Aminoshariae, Amir; Aminoshariae, Anita; Valiathan, Manish; Kulild, James C.

doi:10.2319/011916-50.1

Cited by 14 publications

(11 citation statements)

References 31 publications

(37 reference statements)

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“…External apical root resorption (EARR) following orthodontic treatment is a pathologic side effect of the undesirable activity of specific clastic cells on the root surface that can usually be discerned with routine radiography (Brezniak et al 2004;Aminoshariae et al 2016).…”

Section: Cellular Components and Adaptations During Root Resorptionmentioning

confidence: 99%

Cellular and Molecular Pathways Leading to External Root Resorption

2016

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External apical root resorption during orthodontic treatment implicates specific molecular pathways that orchestrate nonphysiologic cellular activation. To date, a substantial number of in vitro and in vivo molecular, genomic, and proteomic studies have supplied data that provide new insights into root resorption. Recent mechanisms and developments reviewed here include the role of the cellular component-specifically, the balance of CD68 + , iNOS + M1-and CD68 + , CD163 + M2-like macrophages associated with root resorption and root surface repair processes linked to the expression of the M1-associated proinflammatory cytokine tumor necrosis factor, inducible nitric oxide synthase, the M1 activator interferon γ, the M2 activator interleukin 4, and M2-associated anti-inflammatory interleukin 10 and arginase I. Insights into the role of mesenchymal dental pulp cells in attenuating dentin resorption in homeostasis are also reviewed. Data on recently deciphered molecular pathways are reviewed at the level of (1) clastic cell adhesion in the external apical root resorption process and the specific role of α/β integrins, osteopontin, and related extracellular matrix proteins; (2) clastic cell fusion and activation by the RANKL/RANK/OPG and ATP-P2RX7-IL1 pathways; and (3) regulatory mechanisms of root resorption repair by cementum at the proteomic and transcriptomic levels.

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Section: Cellular Components and Adaptations During Root Resorptionmentioning

confidence: 99%

Cellular and Molecular Pathways Leading to External Root Resorption

2016

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“…As expected, the same factors are implicated in both Pd and pathological root resorption, as both processes are based on the recruitment and activation of osteoclasts (odontoclasts). For example, one polymorphism in the Il-1b gene has been associated with a 5.6-fold higher risk of developing EARR during orthodontic treatment (Aminoshariae et al, 2016). RANKL/RANK/OPG signaling is also implicated in pathological root resorption (Lossdörfer et al, 2002; Iglesias-Linares and Hartsfield, 2016).…”

Section: Discussionmentioning

confidence: 99%

RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model

et al. 2017

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Periodontitis is based on a complex inflammatory over-response combined with possible genetic predisposition factors. The RANKL/RANK/OPG signaling pathway is implicated in bone resorption through its key function in osteoclast differentiation and activation, as well as in the inflammatory response. This central element of osteo-immunology has been suggested to be perturbed in several diseases, including periodontitis, as it is a predisposing factor for this disease. The aim of the present study was to validate this hypothesis using a transgenic mouse line, which over-expresses RANK (RTg) and develops a periodontitis-like phenotype at 5 months of age. RTg mice exhibited severe alveolar bone loss, an increased number of TRAP positive cells, and disorganization of periodontal ligaments. This phenotype was more pronounced in females. We also observed dental root resorption lacunas. Hyperplasia of the gingival epithelium, including Malassez epithelial rests, was visible as early as 25 days, preceding any other symptoms. These results demonstrate that perturbations of the RANKL/RANK/OPG system constitute a core element of periodontitis, and more globally, osteo-immune diseases.

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“…For quality evaluation, the strengthening the reporting of genetic association (STREGA) statement and checklist were followed. 12 Methodologic quality scores were calculated and ranged from 0 (lowest) to 20 (highest). Studies with scores < 10 were considered low-quality studies and those with scores ≥ 10 were considered high-quality studies.…”

Section: Methodsmentioning

confidence: 99%

Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis

et al. 2018

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ObjectiveTo date, only a few studies have investigated the relationships between genetic polymorphisms and external apical root resorption (EARR). Hence, the aim of this systematic review was to explore the relationship between different gene polymorphisms and their association with EARR.MethodsA complete literature search was conducted by two independent reviewers. The PubMed, Science Direct, and Scopus databases were searched. In addition, the bibliographies of all textbooks and relevant articles were searched manually. A meta-analysis was performed using data entered into the electronic databases until February 28, 2017.ResultsOn the basis of the search, we identified 17 and 7 publications for the systematic review and meta-analysis, respectively. Odds ratio (OR) was used to evaluate the association of the interleukin 1B (+3954) polymorphism and the risk of EARR. The overall OR from the studies was used to estimate the risk of EARR. However, no association was found and no publication bias was apparent for the risk of EARR in patients receiving orthodontic treatment.ConclusionsMore research on the relationship between gene polymorphism and EARR is necessary to determine better specificity of possible interactions.

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Association of genetic polymorphism and external apical root resorption

Cited by 14 publications

References 31 publications

Cellular and Molecular Pathways Leading to External Root Resorption

Cellular and Molecular Pathways Leading to External Root Resorption

RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model

Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis

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