Interleukin-1 from epithelial cells fosters T cell-dependent skin inflammation

Abstract

IL-1 secretion and the physical contact between keratinocytes and activated, infiltrating T cells may be central for the development of chronic inflammatory skin conditions.

Co-culture of healthy human keratinocytes and T-cells promotes keratinocyte chemokine production and RORγt-positive IL-17 producing T-cell populations

“…Although previous studies have focused on the interaction between KCs and T-cells, the outcomes have been contradictory [9][10][11][12][13]. This ambiguity may be explained by the use of immortalized KCs or KCs from immune privileged hair follicles in some of these studies, which clearly differ from primary KCs [14,15].…”

Three-Dimensional Skin Models of Psoriasis

“…Moreover, many cytokines found in that spectrum are more intensively secreted. In addition, the ability of immune cells, such as stimulated T cells, to influence cytokine secretion depends on how these cells are stimulated [Martin et al, 2012;Muhr et al, 2010;Renne et al, 2010]. It has also been found that the secretion of one cytokine may influence the secretion of the others.…”

“…Similar approaches are used to study the crosstalk between keratinocytes and immune cells [Martin et al, 2012;Muhr et al, 2010;Renne et al, 2010]. Experimental data suggest that healthy and diseased keratinocytes, when cocultured with T cells, express different cytokines [Martin et al, 2012] and the spectrum of cytokines expressed by diseased cells is wider.…”

Tea Tree Oil as a Novel Antipsoriasis Weapon

“…Importantly, TNF-α is unanimously believed to be the most essential cytokine involved in the immunopathogenesis of psoriasis [4]. It has been recognized that interleukin (IL)-1 production and the physical contact between keratinocytes and activated, infiltrating T cells may be important for the development of chronic inflammatory skin conditions such as psoriasis [5]. Notably, IL-8 has been suggested to take part in the pathophysiology of psoriasis mainly through the neutrophil attraction.…”