Tea Tree Oil as a Novel Antipsoriasis Weapon

Pazyar, Nader; Yaghoobi, Reza

doi:10.1159/000337936

Cited by 17 publications

(9 citation statements)

References 25 publications

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“…Tea tree oil (Melaleuca alternifolia) has antimicrobial and anti-inflammatory features and is reputed to have wound renewal properties [35,36,37]. It has been recognized that cooling is a useful method to decrease tissue injury and increase wound healing.…”

Section: Resultsmentioning

confidence: 99%

Skin Wound Healing and Phytomedicine: A Review

Pazyar

Yaghoobi²,

Rafiee³

et al. 2014

Skin Pharmacol Physiol

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199

137

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Skin integrity is restored by a physiological process aimed at repairing the damaged tissues. The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling. Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing. These include Aloe vera, mimosa, grape vine, Echinacea, chamomile, ginseng, green tea, jojoba, tea tree oil, rosemary, lemon, soybean, comfrey, papaya, oat, garlic, ginkgo, olive oil and ocimum. Phytotherapy may open new avenues for therapeutic intervention on cutaneous wounds. This article provides a review of the common beneficial medicinal plants in the management of skin wounds with an attempt to explain their mechanisms.

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Section: Resultsmentioning

confidence: 99%

Skin Wound Healing and Phytomedicine: A Review

Pazyar

Yaghoobi²,

Rafiee³

et al. 2014

Skin Pharmacol Physiol

Self Cite

199

137

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“…Management of psoriasis is difficult because the distribution and severity of psoriatic plaques vary enormously . Localized psoriasis is often treated with topical preparations such as emollients, keratolytics, corticosteroids, tars, calcipotriol, dithranol and tazarotene.…”

Section: What Is Known and Objectivementioning

confidence: 99%

Safety and efficacy of kunzea oil-containing formulations for the management of psoriasis: a randomized, controlled trial

et al. 2015

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“…The Psoriasis Area and Severity Index (PASI) [35] represents the most common score for the assessment of psoriasis severity in clinical trials and practice. The accuracy of the PASI as a global score for psoriasis severity and for making therapeutic decisions is more than questionable [31,32,33,36]. On the other hand, reflectance confocal microscopy (RCM), a novel non-invasive, in vivo imaging technique, has been used increasingly in recent years for investigating psoriatic skin lesions, which showed a good correlation with histological findings [37,38,39].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Histological and Clinical Course of Psoriasis: A Pilot Investigation by Reflectance Confocal Microscopy during Goeckerman Treatment

Archid¹,

Duerr²,

Patzelt

et al. 2016

Skin Pharmacol Physiol

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Alterations of the skin microvasculature are known to play an important role in the development and maintenance of psoriatic skin lesions. In this study, we investigated lesional skin in 11 psoriatic patients during a modified Goeckerman treatment using reflectance confocal microscopy (RCM) to study the relationship between clinical clearance and histological normalization of psoriatic skin and the significance of histological abnormalities on the course of disease. The treatment regimen resulted in a significant reduction of the Psoriasis Area and Severity Index (PASI) as well as capillary and papillary diameters (p < 0.0001). The capillary and papillary diameters were still enlarged when compared to those in normal skin (p < 0.001). Capillary and papillary diameters correlated with each other prior to and after treatment (correlation coefficient = 0.63 and 0.64, p = 0.01 and 0.002, respectively) but not with the PASI. Capillary and papillary diameters after treatment and percentage reduction of the PASI during treatment seemed to be better predictors for the clinical course of relapse than the PASI after treatment. These findings make the subclinical changes of psoriatic skin vessels and dermal papillae a legitimate target for treatment. Further investigations of a large group of patients are needed to evaluate the potential of RCM findings as successor of the PASI in the monitoring of psoriasis.

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Tea Tree Oil as a Novel Antipsoriasis Weapon

Cited by 17 publications

References 25 publications

Skin Wound Healing and Phytomedicine: A Review

Skin Wound Healing and Phytomedicine: A Review

Safety and efficacy of kunzea oil-containing formulations for the management of psoriasis: a randomized, controlled trial

Relationship between Histological and Clinical Course of Psoriasis: A Pilot Investigation by Reflectance Confocal Microscopy during Goeckerman Treatment

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