Interferon status as a method of determination of nonspecific biomarkers of human immunopathology

Ершов, Ф И; Оспельникова, Т. П.; Наровлянский, А. Н.

doi:10.36233/0372-9311-2019-3-91-99

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…У пациенток второй группы в отличие от первой наблюдалось увеличение в сыворотке периферической крови концентрации TNFα в 3,79 раза (р=0,000001), IL-1β -в 4,8 раза (р=0,000001), IFNγ -в 1,73 раза (р=0,000001) и IL-2 -в 2,91 раза (р=0,000001) (табл.). По-видимому, более высокий уровень провоспалительных цитокинов инициировал миграцию иммуноцитов в очаги инфекционно-воспалительных изменений в мелких бронхах [6], что способствовало: 1) угнетению репродукции возбудителей внутри эпителиоцитов; 2) участию NK и цитотоксических лимфоцитов в удалении продуктов деструкции из клеток; 3) формированию защиты от вирусных частиц рядом расположенных незараженных эпителиоцитов; 4) стимуляции выработки IFNγ; 5) запуску реакций перераспределения Т-лимфоцитов; 6) активации в клетках экспрессии генов IL-1 и TNFα; 7) стимуляции синтеза других провоспалительных и противовоспалительных цитокинов [7,8].…”

Section: результаты исследования и их обсуждениеunclassified

Changes in the cytokine status in women with exacerbation of bronchial asthma due to reactivation of cytomegalovirus infection in the second trimester of pregnancy

Andrievskaya,

Nakhamchen,

Gorikov

et al. 2023

Bûlletenʹ fiziologii i patologii dyhaniâ

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Aim. To study changes in the cytokine status in women with exacerbation of bronchial asthma caused by reactivation of cytomegalovirus infection (CMVI) in the second trimester of gestation.Materials and methods. The concentration of pro-inflammatory cytokines (TNFα, IL-1β, IFNγ, IL-2) in blood serum was assessed in 112 women in the second trimester of pregnancy, uncomplicated and complicated by exacerbation of asthma caused by reactivation of CMVI. The first group included 30 women seronegative for CMVI with uncomplicated pregnancy. The second group consisted of 30 patients with exacerbation of mild asthma associated with CMVI, initiating the formation of chronic compensated placental insufficiency. The third group consisted of 27 patients with exacerbation of moderate asthma induced by CMVI reactivation leading to the development of chronic compensated placental insufficiency. The fourth group included 25 women with exacerbation of moderate asthma due to the acute phase of CMVI, which induces the development of chronic subcompensated placental insufficiency.Results. It was found that in the blood serum of women of the first group, the concentration of TNFα was (Me) 21.5 (13.8–30.1) pg/mL, IL-1β – 18.2 (13.6–34.0) pg/mL, IFNγ – 137.4 (109.5‒174.2) pg/mL and IL-2 – 29.8 (21.0‒38.9) pg/mL. In patients of the second group, compared with the first one, there was an increase in the level of TNFα by 3.79 times (p=0.000001), IL-1β – by 4.8 times (p=0.000001), IFNγ – by 1.73 times (p=0.000001) and IL-2 by 2.91 times (p=0.000001). In the third group, unlike the second one, no significant differences were found between the concentrations of TNFα, IL-1β, IFNγ, and IL-2. In patients of the fourth group, in comparison with the third group, higher values of TNFα (1.35 times, p=0.00507), IL-1β (1.86 times, p=0.000001), IFNγ (1.31 times, p=0.000167), and IL-2 (1.5 times, p=0.0056) were registered.Conclusion. During exacerbation of moderate asthma of cytomegalovirus etiology, leading to chronic subcompensated placental insufficiency, in comparison with exacerbation of moderate asthma caused by reactivation of CMVI, initiating the formation of chronic compensated placental insufficiency, activation of the systemic inflammatory response is most pronounced, leading to stimulation of the migration of monocytes, lymphocytes and neutrophils to the focus of inflammation at the level of small bronchi; also leading to disruption of intersystem relationships and to hemodynamic dysfunction of the placenta.

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Section: результаты исследования и их обсуждениеunclassified

Changes in the cytokine status in women with exacerbation of bronchial asthma due to reactivation of cytomegalovirus infection in the second trimester of pregnancy

Andrievskaya,

Nakhamchen,

Gorikov

et al. 2023

Bûlletenʹ fiziologii i patologii dyhaniâ

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Characteristics of self-regulation of the epidemic process of infection caused by the Epstein–Barr virus (Herpesviridae: <i>Lymphocryptovirus</i>, HHV-4)

Solomay,

Semenenko,

Akimkin

2023

Problems of Virology

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Introduction. Among the available scientific literature, there are no publications addressing processes of self-regulation in the parasite-host population systems with reference to chronic infections, including the infection caused by the EpsteinBarr virus (EBV infection). The aim of the study is to assess manifestations of the epidemic process of chronic EBV infection through the lens of the basic tenets of the theory of self-regulation of parasitic systems. Materials and methods. The study was performed using data from scientific publications selected from such database sources as Scopus, Web of Science, Cochrane Library, PubMed, CyberLeninka, RSCI, etc. The list of analyzed publications included published articles of the authors of this study, reporting the results of the retrospective epidemiological analysis of the incidence of infectious mononucleosis in Russia in general and in Moscow in particular, as well as the results of the laboratory tests regarding the detection frequency of specific antibodies to EBV proteins. Results. The chronic course of EBV infection promotes a close long-term interaction between the pathogen and the host. The genetic variability of the pathogen and the functions of specific and nonspecific human immune defense systems play a key role in the interaction between two heterogeneous populations and underlie their phasal self-transformation. A variety of social and natural factors (adverse chemical, physical, biological, climatic impacts, etc.) trigger the reactivation of chronic EBV infection, thus providing the continuous existence of additional sources of infection in the host population. Conclusion. The analysis of the manifestations of chronic EBV infection in the context of the theory of self-regulation of parasitic systems promotes the understanding of the factors underlying the unevenness of its epidemic process. The obtained data can be adjusted for other infections having similar transmission mechanisms and virus life cycles (including other herpes infections) to map out strategies to control the epidemic process of chronic infections spread by aerosol transmission of the pathogen.

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Biological activity of interferons in the novel coronavirus infection COVID-19

Оспельникова

Levitskaya

Kolodyazhnaya

et al. 2022

Problems of Virology

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Introduction. The immunopathogenesis of the novel coronavirus infection COVID-19 is usually associated with the development of imbalance in the immune response to its causative agent, SARS-CoV-2 virus (Coronaviridae: Coronavirinae: Betacoronavirus: Sarbecovirus). This is manifested, in particular, by interferons’ (IFNs) deficiency at the beginning of the disease followed by hyperproduction of pro-inflammatory cytokines. The virus causes a decrease in IFN types I (α/β) and III (λ) levels; changes in IFN type II (γ) are less studied. In this regard, it is relevant to assess the functional bioactive IFN (interferon status) in COVID-19. The aim of the study was to assess the antiviral potential of the body by testing the biologically active IFNs in COVID-19.Material and methods. We used biological serum samples of COVID-19 patients taken in the acute phase (110 patients on the 1–5 days of the disease) and during rehabilitation (47 patients during 1–3 months after the disease onset). Assessment of interferon status was performed according to the technique developed by the authors and described earlier.Results. The IFN status of patients with COVID-19 in the acute period and in the phase of post-infection rehabilitation was studied вduring the observation period. It was found that SARS-CoV-2 causes a pronounced inhibition of biological activity of IFN types I and II compared to the reference values by more than 20 and 7 times, respectively. During the post-COVID period, incomplete recovery of the IFN system activity was registered, which proceeded very slowly. No cases of reaching physiological indicators of interferon status were identified during the observation period.Conclusion. The obtained data on deficiency of the functional biologically active IFN confirm the hypothesis about the predominant role of impaired IFN production of different types in the immunopathogenesis of the novel coronavirus infection.

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Interferon status as a method of determination of nonspecific biomarkers of human immunopathology

Cited by 3 publications

References 42 publications

Changes in the cytokine status in women with exacerbation of bronchial asthma due to reactivation of cytomegalovirus infection in the second trimester of pregnancy

Changes in the cytokine status in women with exacerbation of bronchial asthma due to reactivation of cytomegalovirus infection in the second trimester of pregnancy

Characteristics of self-regulation of the epidemic process of infection caused by the Epstein–Barr virus (Herpesviridae: <i>Lymphocryptovirus</i>, HHV-4)

Biological activity of interferons in the novel coronavirus infection COVID-19

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