Interferon lambda 1–3 expression in infants hospitalized for RSV or HRV associated bronchiolitis

Selvaggi, Carla; Pierangeli, Alessandra; Fabiani, Marco; Spanò, Lucia; Nicolai, Ambra; Papoff, Paola; Moretti, Corrado; Midulla, Fabio; Antonelli, Guido; Scagnolari, Carolina

doi:10.1016/j.jinf.2013.12.010

Cited by 58 publications

(54 citation statements)

References 61 publications

(59 reference statements)

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“…In nasopharyngeal wash samples from infants hospitalized for RSV associated bronchiolitis, IFN-λ expression correlates positively both with anti-viral ISG expression and with the clinical score index of disease severity, but not with viral load. It should be noted however, that type I IFNs were not measured in this study, so it is unclear whether IFN-λ or another IFN was responsible for ISG expression (Selvaggi et al, 2014). …”

Section: Discussionmentioning

confidence: 93%

Respiratory syncytial virus infection induces a subset of types I and III interferons in human dendritic cells

et al. 2017

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Whether respiratory syncytial virus (RSV) induces severe infantile pulmonary disease may depend on viral strain and expression of types I and III interferons (IFNs). These IFNs impact disease severity by inducing expression of many anti-viral IFN-stimulated genes (ISGs). To investigate the impact of RSV strain on IFN and ISG expression, we stimulated human monocyte-derived DCs (MDDCs) with either RSV A2 or Line 19 and measured expression of types I and III IFNs and ISGs. At 24h, A2 elicited higher ISG expression than Line 19. Both strains induced MDDCs to express genes for IFN-β, IFN-α1, IFN-α8, and IFN-λ1–3, but only A2 induced IFN-α2, -α14 and -α21. We then show that IFN-α8 and IFN-α14 most potently induced MDDCs and bronchial epithelial cells (BECs) to express ISGs. Our findings demonstrate that RSV strain may impact patterns of types I and III IFN expression and the magnitude of the ISG response by DCs and BECs.

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Section: Discussionmentioning

confidence: 93%

Respiratory syncytial virus infection induces a subset of types I and III interferons in human dendritic cells

et al. 2017

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“…Recently, a positive correlation was shown for the clinical score index and the levels of IFN-l1 in nasopharyngeal washes from patients with hRSV bronchiolitis [31 ]. Specifically, IFN-l1 seems to be associated with an increase in respiratory rate during hRSV infection [31 ].…”

Section: Acute Damage and Early Immune Response Against Hrsv In The Amentioning

confidence: 99%

“…Also, viral loads were higher in IFNAR1 À/À mice as compared to wild type mice [26]. Control of viral infection in AECs is also by the activity of type III IFNs [31 ] upon binding to the receptor expressed on epithelial cells at mucosal surfaces [27,32]. Recently, a positive correlation was shown for the clinical score index and the levels of IFN-l1 in nasopharyngeal washes from patients with hRSV bronchiolitis [31 ].…”

Section: Acute Damage and Early Immune Response Against Hrsv In The Amentioning

confidence: 99%

“…Control of viral infection in AECs is also by the activity of type III IFNs [31 ] upon binding to the receptor expressed on epithelial cells at mucosal surfaces [27,32]. Recently, a positive correlation was shown for the clinical score index and the levels of IFN-l1 in nasopharyngeal washes from patients with hRSV bronchiolitis [31 ]. Specifically, IFN-l1 seems to be associated with an increase in respiratory rate during hRSV infection [31 ].…”

Section: Acute Damage and Early Immune Response Against Hrsv In The Amentioning

confidence: 99%

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Inflammatory damage on respiratory and nervous systems due to hRSV infection

Böhmwald¹,

Espinoza²,

Becerra³

et al. 2015

Current Opinion in Immunology

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“…Currently, IFN-λ is designated as a therapeutic candidate against the influenza A virus (IAV) infection (32, 33). In infants hospitalized for respiratory syncytial virus (RSV)- or human rhinovirus (HRV)-associated bronchiolitis, RSV elicited higher levels of IFN-λ subtypes when compared with HRV (34). …”

Section: Role Of Ifn-λ In the Control Of Viral Infections Of The Respmentioning

confidence: 99%

IFN-λ: A New Inducer of Local Immunity against Cancer and Infections

et al. 2016

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IFN-λ is the newly established type III IFN with unique immunomodulatory functions. In contrast to the IFN-α/β family and to some extent IFN-γ, IFN-λ is apparently acting in specific areas of the body to activate resident immune cells and induces a local immunity, instrumental in preventing particular infections and also keeping transformed cells under control. Mucosal areas of lung and gastrointestinal tracts are now under scrutiny to elucidate the immune mechanisms triggered by IFN-λ and leading to viral protection. New evidence also indicates the crucial role of IFN-λ in promoting innate immunity in solid cancer models. Based on its unique biological activities among the IFN system, new immunotherapeutic approaches are now emerging for the treatment of cancer, infection, and autoimmune diseases. In the present review, we highlight the recent advances of IFN-λ immunomodulatory functions. We also discuss the perspectives of IFN-λ as a therapeutic agent.

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Interferon lambda 1–3 expression in infants hospitalized for RSV or HRV associated bronchiolitis

Abstract: These findings show that differences in the IFN lambda 1-3 levels in infants with RSV or HRV infections are present and that the expression of IFN lambda 1 correlates with the severity of RSV bronchiolitis.

Cited by 58 publications

References 61 publications

Respiratory syncytial virus infection induces a subset of types I and III interferons in human dendritic cells

Respiratory syncytial virus infection induces a subset of types I and III interferons in human dendritic cells

Inflammatory damage on respiratory and nervous systems due to hRSV infection

IFN-λ: A New Inducer of Local Immunity against Cancer and Infections

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