Interferon-Alpha-Associated Sarcoidosis Responsive to Infliximab Therapy

Menon, Yamini; Cucurull, E; Reisin, Efrain; Espinoza, Luis R.

doi:10.1097/00000441-200409000-00008

Cited by 49 publications

(22 citation statements)

References 20 publications

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“…Management, where necessary, ranges from the removal of isolated nodules to corticotherapy in patients with systemic manifestations of sarcoidosis or a prolonged disease course. A recent publication has described a good response to three doses of infliximab (5 mg/kg) in a patient with systemic sarcoidosis refractory to corticoids, induced by interferon administered as therapy for chronic hepatitis C [13].…”

Section: Discussionmentioning

confidence: 99%

Interferon-induced cutaneous sarcoidosis in melanoma

Suárez-García

Pérez‐Gil²,

Pereira-Gallardo³

et al. 2009

Melanoma Research

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Interferon-induced cutaneous sarcoidosis in the adjuvant treatment of melanoma is a rare side effect. We present the case of a patient who developed two histologically confirmed subcutaneous sarcoid nodules 15 months after starting adjuvant therapy with interferon for lymph node metastatic melanoma in which the primary tumor was not known. The extension study, coinciding with occurrence of the nodules, showed no systemic sarcoidosis. This therefore represents the second reported case of interferon-induced cutaneous sarcoidosis in melanoma therapy. As computed axial tomography-PET or other imaging techniques are unable to differentiate between the radiological signs of melanoma metastasis and sarcoidosis, histological evaluation of the granulomatous lesions is essential with a view to avoiding unnecessary treatments.

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Section: Discussionmentioning

confidence: 99%

Interferon-induced cutaneous sarcoidosis in melanoma

Suárez-García

Pérez‐Gil²,

Pereira-Gallardo³

et al. 2009

Melanoma Research

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“…It has been speculated that interferon itself can stimulate granuloma production, and there are several reported cases of the development of sarcoidosis in patients receiving interferon therapy [15][16][17][18][19] . This is thought to be related to the ability of interferon to stimulate a Th 1 immune response which is felt to be responsible for the granulomas in sarcoidosis [20] .…”

Section: Discussionmentioning

confidence: 99%

Chronic hepatitis C is a common associated with hepatic granulomas

Snyder¹,

Martı́nez²,

Xiao³

2008

WJG

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“…Anti-TNF therapy improves bone density in rheumatoid arthritis, but whether such therapy improves bone density in patients with sarcoidosis and osteoporosis/osteopenia has not been directly assessed. However, reports have emerged of TNF inhibitors decreasing levels of calcium in patients with sarcoidosis [45]. Although the cause of this decrease remains incompletely characterized, a link between TNF and hypercalcemia has been suggested for years [46, 47], and the role of TNF in sarcoidosis also has been established [48].…”

Section: Proposed Algorithm To Maintain Bone Health In Sarcoidosismentioning

confidence: 99%

Bone Health Issues in Sarcoidosis

et al. 2011

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Sarcoidosis affects the bone directly in only a minority of patients. Nonetheless, bone health should be considered in the management of all patients with sarcoidosis. Deficiency in vitamin D, an important contributor to bone health, has been linked to autoimmune disease incidence. Studies have shown that patients with sarcoidosis frequently have low levels of vitamin D-25 but may have normal or increased levels of vitamin D-1,25. In addition, granuloma formation has been linked to a failure of the innate immune system, which could be related to a deficiency in vitamin D, although this relationship has not been fully characterized. Furthermore, many patients with sarcoidosis are treated with corticosteroids, which are known to induce osteoporosis. Therefore, bone health may be impacted in several ways in sarcoidosis—by direct involvement with granulomas, vitamin D deficiency, or corticosteroid therapy.

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Interferon-Alpha-Associated Sarcoidosis Responsive to Infliximab Therapy

Cited by 49 publications

References 20 publications

Interferon-induced cutaneous sarcoidosis in melanoma

Interferon-induced cutaneous sarcoidosis in melanoma

Chronic hepatitis C is a common associated with hepatic granulomas

Bone Health Issues in Sarcoidosis

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