Chronic hepatitis C is a common associated with hepatic granulomas

Snyder, Ned; Martı́nez, Juan Gabriel; Xiao, Shu‐Yuan

doi:10.3748/wjg.14.6366

Cited by 17 publications

(3 citation statements)

References 19 publications

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“…Two patients were co‐infected with HCV and HBV, and therefore the cause of granuloma could not be attributed to one of the viruses. While chronic HVC is a well‐acknowledged cause of hepatic granulomas, the prevalence of granulomas in the setting of chronic HBV infection has been reported less often. For example, in the two UK series published to date, no cases of granuloma were reported among patients infected with HBV .…”

Section: Discussionmentioning

confidence: 99%

Hepatic granulomas: a 17‐year single tertiary centre experience

et al. 2018

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Hepatic granulomas can result from various infectious and non-infectious diseases. During recent years, an epidemiological shift regarding granuloma aetiology was observed, from systemic infectious diseases to non-infectious, mainly immune-mediated primary liver disorders. With an appropriate work-up the aetiology can be identified in the vast majority of cases (~90%), rendering its histological identification and characterisation essential, as disease-specific therapies are becoming available.

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Section: Discussionmentioning

confidence: 99%

Hepatic granulomas: a 17‐year single tertiary centre experience

et al. 2018

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“…66 HCV infection and hepatitis B have been associated with GLD in the absence of other attributable causes. [67][68][69] In patients with HCV chronic infection undergoing liver biopsy, a prevalence of 1.3 % has been reported, mainly in patients with a history of treatment with interferon. 67,70 Due to the availability of new non-invasive techniques for fibrosis staging in these patients, as well as to the advent of more effective antiviral treatments, it is expected that these GLD etiologies will be only sporadically found in the future.…”

Section: Zoonosismentioning

confidence: 99%

Granulomatous liver disease

Ortíz-Brizuela¹,

Azamar-Llamas²,

Mora³

et al. 2023

GMM

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Granulomas are mainly composed of macrophages and T cells. The immune phenotype that triggers them and their histological appearance differ according to their etiology and to the host immune status. 1,4,5 For example, exposure to weakly antigenic agents results in the formation of persistent low-turnover granulomas (e.g., sutures), also called foreign-body granulomas (Figure 1). On the other hand, exposure to highly antigenic stimuli (e.g., Mycobacterium tuberculosis) results in additional activation of adaptive immune responses and in the formation of more complex granulomas (immune granulomas) (Figure 2). 1,6 Both, the innate and adaptive immune systems, are involved in their formation and maintenance. 7 In the case of Mycobacterium tuberculosis, its recognition through various macrophage receptors (e.g., complement receptor 4), among others, allows the T-helper cells activation into Th1, Th2, Th17 or regulatory T cells, as well as recruitment of other inflammatory cells (macrophages, neutrophils, B-cells). This results in the formation of the granuloma structure: a center composed

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“…Las infecciones por los virus de las hepatitis C y B se han asociado con EGH en ausencia de otras causas atribuibles. [67][68][69] En los pacientes con infección crónica por VHC sometidos a biopsia hepática se ha reportado una prevalencia de 1.3 %, principalmente en pacientes con antecedente de tratamiento con interferón. 67,70 Debido a la disponibilidad de nuevas técnicas no invasivas para la estadificación de la fibrosis en estos pacientes, así como el advenimiento de tratamiento antivirales más efectivos, es esperable que en el futuro encontremos esporádicamente estas etiologías de EGH.…”

Section: Infección Por Vhc Y Vhbunclassified

Enfermedad granulomatosa hepática

Ortíz-Brizuela

Azamar-Llamas

Mora

et al. 2019

GMM

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Los granulomas son lesiones circunscritas compuestas principalmente por células mononucleares que surgen en respuesta a estímulos antigénicos pobremente degradables. Se encuentran en 2 a 15 % de las biopsias hepáticas; su hallazgo puede significar desde un fenómeno incidental, hasta la manifestación de una enfermedad sistémica de origen infeccioso, autoinmune o neoplásico. El cuadro clínico suele apuntar a la patología subyacente, sin embargo, la lista de condiciones asociadas es amplia y difiere con base en los antecedentes epidemiológicos y a las características basales del paciente. El elemento de mayor utilidad para su estudio es la historia clínica exhaustiva, con énfasis en viajes recientes, exposición de riesgo y consumo de fármacos o alimentos crudos o exóticos. El análisis histopatológico detallado puede auxiliar en la identificación de la etiología, por ejemplo, la presencia de granulomas epitelioides con necrosis caseosa indica tuberculosis y su ausencia, sarcoidosis; la abundancia de eosinófilos es señal de reacciones farmacológicas o infecciones parasitarias; la presencia de cuerpos extraños puede ser la causa de la enfermedad granulomatosa hepática. En este artículo describimos los aspectos clínico-patológicos básicos de esta enfermedad y proveemos un breve resumen de las etiologías más comunes, principalmente en la región de Latinoamérica.

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Chronic hepatitis C is a common associated with hepatic granulomas

Abstract: else is found, the clinician can be comfortable with an HCV association.

Cited by 17 publications

References 19 publications

Hepatic granulomas: a 17‐year single tertiary centre experience

Hepatic granulomas: a 17‐year single tertiary centre experience

Granulomatous liver disease

Enfermedad granulomatosa hepática

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