Bone Health Issues in Sarcoidosis

Sweiss, Nadera J.; Lower, Elyse E.; Korsten, Peter; Niewold, Timothy B.; Favus, Murray J.; Baughman, Robert P.

doi:10.1007/s11926-011-0170-1

Cited by 48 publications

(29 citation statements)

References 53 publications

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“…Although most of the patient population was vitamin D deficient, 71% of patients had normal values of the active form of vitamin 1,25(OH)2D. In patients with sarcoidosis (most of them) there are normal serum levels of active calcitriol but low levels of inactive vitamin 25(OH)D (18).…”

Section: Vitamin D and Sarcoidosis -Novel Observationsmentioning

confidence: 99%

“…Severe vitamin D deficiency is thought to sensitize the antigen-presenting capacity of dendritic cells (21). High activity of dendritic cells could direct the immune response toward endogenous body molecules thus leading to autoimmune diseases such as systemic lupus erythematosus (21) or even sarcoidosis (18).…”

Section: The Role Of Vitamin 125(oh)2d In Sarcoidosismentioning

confidence: 99%

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The role of vitamin D in multisystem sarcoidosis / Uloga vitamina D u sarkoidozi

Mihailović-Vučinić¹,

Ignjatović²,

Dudvarski-Ilić³

et al. 2012

Journal of Medical Biochemistry

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Summary: Recently published data indicate that vitamin D abnormalities are common in sarcoidosis patients. The purpose of this study was to compare serum vitamin 25(OH)D levels among sarcoidosis patients with different clinical courses of the disease. The study also included the first observations on cognitive functions (i.e. depression and fatigue syndrome) in relation to vitamin D deficiency in sarcoidosis patients. At the Biochemical Laboratory of the Clinical Center of Serbia, Belgrade, vitamin D25(OH)D was measured using the Elecsys ® Vitamin D total test. A total of 226 patients with biopsy-positive sarcoidosis were analyzed. The average median value of serum vitamin D was 9.47 mg/L, suggesting severe deficiency. Statistically significant correlation was found in patients with chronic disease and low levels of serum vitamin 25(OH)D (Chi-Square=6.044; df=2; p=0.014). The patient group with vitamin D serum levels higher than 20 mg/L showed higher levels of the mean forced vi tal capacity (FVC) by 380 mL, and forced expiratory volume in one second (FEV1) by 220 mL, when compared to the patient group with lower serum vitamin D. A statistically significant role was established for serum vitamin 25(OH)D levels as the predictor of fatigue (R 2 =0.878; p=0.038 (b=0.216)) and depression in patients with sarcoidosis (R 2 =0.80; p=0.000 (b=0.391)). The insufficiency of 25(OH)D seems to be an important factor in predicting the course of chronic disease, significant lung function impairments and cognitive failures such as fatigue and depression. The fact that the majo rity of the analyzed sarcoidosis patients had totally deficient serum 25(OH)D levels made this finding even more notable. Keywords: vitamin D, deficiency, sarcoidosisKratak sadr`aj: Nedavno objavljena istra`ivanja kod obole lih od sarkoidoze govore o ~estim abnormalnim vrednostima vitamina D. Cilj ove studije bio je da se uporedi nivo vita mina 25(OH)D kod obolelih od sarkoidoze sa razli~itim klini~kim tokom bolesti. Tako|e, ova studija predstavlja prva za pa `anja o vezi izme|u kognitivnih funkcija (odnosno ose}a ja depresije i zamora) i deficita vitamina D kod obolelih od sarko idoze. U Biohemijskoj laboratoriji Klini~kog centra Srbije vitamin D -25(OH)D meren je kori{}enjem testa Elec sys ® Vitamin D. Analizirano je 226 bolesnika sa sarkoidozom potvr|enom biopsijom. Prose~na srednja vrednost vitamina D u serumu bila je 9,47 mg/L, {to ukazuje na ozbiljan nedostatak. Statisti~ki zna~ajna korelacija na |e na je kod pa cije nata sa hroni~nom formom bolesti i niskim nivoom vitamina 25(OH)D u serumu (Xi-kvad rat=6,044; df=2; p=0,014). Grupa pacijenata sa nivoom vitamina D u serumu ve}im od 20 mg/L pokazuje ve}i nivo srednjeg for siranog vitalnog kapaciteta (FVC) za 380 mL i forsiranog ekspi ratornog volumena u prvoj sekundi (FEV1) za 220 mL u od nosu na grupu pacijenata sa ni`im nivoom D vitamina. Utvr|eno je da nivo vitamina 25(OH)D u serumu ima stati sti~ki zna~ajnu ulogu kao prediktor zamora i depresije kod obolelih od sarkoidoze. Insuficijencija 25(OH)D ...

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Section: Vitamin D and Sarcoidosis -Novel Observationsmentioning

confidence: 99%

Section: The Role Of Vitamin 125(oh)2d In Sarcoidosismentioning

confidence: 99%

The role of vitamin D in multisystem sarcoidosis / Uloga vitamina D u sarkoidozi

Mihailović-Vučinić¹,

Ignjatović²,

Dudvarski-Ilić³

et al. 2012

Journal of Medical Biochemistry

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“…Sarcoidosis is usually polyostotic, and it typically involves the skull, arms and the long bones of hands and feet, but rarely the calcaneus. As with eosinophilic granulomas, lesions are cystic in nature, well delimited, but without drainage fistulae (Sweiss et al, 2011).…”

Section: Osteoarthritismentioning

confidence: 99%

A case of calcaneal osteomyelitis from the prehispanic population of El Hierro (Canary Islands)

González‐Reimers

Trujillo-Mederos

Ordóñez

et al. 2015

International Journal of Paleopathology

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“…A low 25-hydroxy vitamin D level in an active sarcoidosis patient may be the result of excessive conversion of 25-hydroxy vitamin D to 1,25-hydroxy vitamin D. Treatment of such patients for a ''low vitamin D level'' may have disastrous consequences, such as nephrolithiasis or renal failure. [82][83][84] To complicate matters further, vitamin D and calcium dysregulation, as well as chronic steroid use, may affect bone health. 83 For the reasons outlined above, a detailed analysis of vitamin D status is required before administering vitamin D to patients with sarcoidosis.…”

Section: Cardiac Sarcoidosismentioning

confidence: 99%

“…[82][83][84] To complicate matters further, vitamin D and calcium dysregulation, as well as chronic steroid use, may affect bone health. 83 For the reasons outlined above, a detailed analysis of vitamin D status is required before administering vitamin D to patients with sarcoidosis. Bisphosphonates may be recommended for sarcoidosis patients with osteoporosis or those subjected to chronic corticosteroids.…”

Section: Cardiac Sarcoidosismentioning

confidence: 99%