Using the method of composite material complex and constructing new stress functions with complex singularity exponents, the problem of singularities near interface crack tip for mode II of orthotropic bi-material is studied. Boundary value problems of generalized bi-harmonic equations can be solved with the help of boundary conditions, then four kinds of stress singularities are deduced, respectively, such as the constant singularity at λ=-1/2, the non-constant singularity at λ=-1/2+ε , the constant oscillation singularity at λ=-1/2+iε, and non-constant oscillation singularity at λ=-1/2+c+iε. For each case, the analytic expressions for stress intensity factors near the central-penetrated interface crack tip for mode II of orthotropic bi-material are obtained.