Interest of metabonomic approach in environmental nephrotoxicants: Application to aristolochic acid exposure

Duquesne, M.; Declèves, Anne Émilie; Prez, Eric De; Nortier, Joëlle; Colet, Jean‐Marie

doi:10.1016/j.fct.2017.07.015

Cited by 9 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reagent strips consist of a multilayer test area containing reagents that will react with the required enzymes. The colour intensity of reaction product was measured by reflection spectrophotometry using the SPOTCHEM analyser (A MENARINI SPOTCHEM ™ EZ SP-4430) as detailed in a previous publication [29].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study

Valentini

Rugira

Frau

et al. 2019

Journal of Toxicology

View full text Add to dashboard Cite

Titanium dioxide (TiO2) nanoparticles (NPs) are produced abundantly and are frequently used as a white pigment in the manufacture of paints, foods, paper, and toothpaste. Despite the wide ranges of uses, there is a lack of information on the impact of NPs on animal and human health. In the present study, rats were exposed to different doses of TiO2 nanoparticles and sacrificed, respectively, 4 days, 1 month, and 2 months after treatment. Dosage of TiO2 in tissues was performed by ICP-AES and revealed an important accumulation of TiO2 in the liver. The nanoparticles induced morphological and physiological alterations in liver and kidney. In the liver, these alterations mainly affect the hepatocytes located around the centrilobular veins. These cells were the site of an oxidative stress evidenced by immunocytochemical detection of 4-hydroxynonenal (4-HNE). Kupffer cells are also the site of an important oxidative stress following the massive internalization of TiO2 nanoparticles. Enzymatic markers of liver and kidney functions (such as AST and uric acid) are also disrupted only in animals exposed to highest doses. The metabonomic approach allowed us to detect modifications in urine samples already detectable after 4 days in animals treated at the lowest dose. This metabonomic pattern testifies an oxidative stress as well as renal and hepatic alterations.

show abstract

Section: Methodsmentioning

confidence: 99%

“…After mean-centering of the data without scaling, multivariate analysis was conducted. Principal component analysis (PCA) and partial least square discriminant analysis (PLS-DA) were carried out to discriminate the metabolic patterns between treated rats and controls as detailed in a previous publication [29].…”

Section: Methodsmentioning

confidence: 99%

Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study

Valentini

Rugira

Frau

et al. 2019

Journal of Toxicology

View full text Add to dashboard Cite

show abstract

“…These dosedependent effects already noticed at early stages were morphologically confirmed at later time points. Renal damages were more pronounced with the mixture or AAII alone than AAI alone [18].…”

Section: Nephrotoxicity Assessment By the 'Omics' Approachmentioning

confidence: 88%

“…When abnormal levels of those markers are noticed, irreversible damages were already set up. In this regard, the 'omics' approach could constitute a strategic tool to identify early markers which could allow an early therapeutic intervention [18].…”

Section: Conventional Biomarkersmentioning

confidence: 99%

“…This chapter aims at giving a global picture of AAN with an intended emphasis on the "omics" assessment of this nephrotoxicity, especially on the metabonomic investigation of urine samples. Indeed, it could represent a strategic tool allowing to identify early biomarkers following AA intoxication thereby providing an early detection of the toxicity and a rapid therapeutic intervention [18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Translational Metabonomic Assessment of Aristolochic Acid- Induced Nephropathies

Jadot¹,

Duquesne²,

Declèves³

et al. 2018

Advances in Nephropathy

View full text Add to dashboard Cite

Aristolochic acid nephropathy (AAN) is a global term including any form of toxic interstitial nephropathy that is caused either by the ingestion of plants containing aristolochic acids (AA) as part of traditional phytotherapies or by the environmental contaminants in food. Originally, AAN was reported in Belgium in individuals having ingested slimming pills containing powdered root extracts of a Chinese herb, Aristolochia fangchi. However, it is estimated that exposure to AA affects thousands of people all over the world, particularly in the Balkans, Taiwan and China. Despite warnings from the Regulatory Agencies regarding the safety of products containing AA, many AAN cases remain frequently described worldwide. This chapter aims at giving a global picture of AAN through the descriptions of clinical cases and animal models, which were developed to better understand the mode of action of AA when inducing acute/chronic kidney diseases. Major advances in the translational research on biomarkers of AAN are reviewed, with an intended emphasis on the "omics" assessment of this nephrotoxicity.

show abstract

Aristolochic Acid Nephropathy and Balkan Nephropathy

Nortier

Vanherweghem

Jelaković

2022

Tubulointerstitial Nephritis

View full text Add to dashboard Cite

Interest of metabonomic approach in environmental nephrotoxicants: Application to aristolochic acid exposure

Cited by 9 publications

References 30 publications

Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study

Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study

A Translational Metabonomic Assessment of Aristolochic Acid- Induced Nephropathies

Aristolochic Acid Nephropathy and Balkan Nephropathy

Contact Info

Product

Resources

About

Interest of metabonomic approach in environmental nephrotoxicants: Application to aristolochic acid exposure

Cited by 9 publications

References 30 publications

Hepatic and Renal Toxicity Induced by TiO2 Nanoparticles in Rats: A Morphological and Metabonomic Study

Hepatic and Renal Toxicity Induced by TiO2 Nanoparticles in Rats: A Morphological and Metabonomic Study

A Translational Metabonomic Assessment of Aristolochic Acid- Induced Nephropathies

Aristolochic Acid Nephropathy and Balkan Nephropathy

Contact Info

Product

Resources

About

Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study

Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study