Aristolochic Acid Nephropathy and Balkan Nephropathy

Nortier, Joëlle; Vanherweghem, Jean‐Louis; Jelaković, Bojan

doi:10.1007/978-3-030-93438-5_16

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Aas Can Cause Cancer and Can Be Exposed To The Environment1

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2023

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“…In 1969, AAs were linked to the etiology of BEN when the regional concentration of kidney cancer patients was observed [ 23 ]. It has been demonstrated that BEN is caused by a genotoxic mutagen produced by AAs after metabolism in the human body [ 24 ].…”

Section: Aas Can Cause Cancer and Can Be Exposed To The Environmentmentioning

confidence: 99%

Detection and Removal of Aristolochic Acid in Natural Plants, Pharmaceuticals, and Environmental and Biological Samples: A Review

Wang,

Liu,

Han

et al. 2023

Molecules

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Aristolochic acids (AAs) are a toxic substance present in certain natural plants. Direct human exposure to these plants containing AAs leads to a severe and irreversible condition known as aristolochic acid nephropathy (AAN). Additionally, AAs accumulation in the food chain through environmental mediators can trigger Balkan endemic nephropathy (BEN), an environmental variant of AAN. This paper presents a concise overview of the oncogenic pathways associated with AAs and explores the various routes of environmental exposure to AAs. The detection and removal of AAs in natural plants, drugs, and environmental and biological samples were classified and summarized, and the advantages and disadvantages of the various methods were analyzed. It is hoped that this review can provide effective insights into the detection and removal of AAs in the future.

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Section: Aas Can Cause Cancer and Can Be Exposed To The Environmentmentioning

confidence: 99%