Interdisciplinary therapy changes superoxide dismutase activity and adiponectin in obese adolescents: a randomised controlled trial

Abstract

The objective of this study is to evaluate the effect of interdisciplinary therapy in the parameters of the oxidative stress and the anti-inflammatory responses of obese adolescents. We selected 57 participants, who were randomly divided into 2 groups: interdisciplinary therapy group and a control group. After 6 months of intervention, 17 participants of the interdisciplinary therapy group and 8 of the control group returned for re-evaluation. The interdisciplinary therapy group participated in a treatment with 4 weekly sessions of exercise, a weekly group therapy session and a weekly nutritional education session. Blood parameters of oxidative stress and anti-inflammatory response were evaluated. The results demonstrated that there were significant increases in the interdisciplinary therapy group for superoxide dismutase activity (6.56 ± 3.22 to 11.40 ± 7.49) and ferric-reducing antioxidant potential concentration (532.91 ± 106.48 to 573.25 ± 112.57), although adiponectin levels did not reduce (40.9 ± 29.34 to 49.05 ± 41.22). A significant decrease in nitrite levels was also found (14.23 ± 8.48 to 11.45 ± 6.05). In the control group, significant reduction was found in adiponectin (31.56 ± 18.88 to 18.01 ± 11.66). This study suggests that interdisciplinary therapy for 6 months was effective in improving the anti-inflammatory responses and the antioxidant defences in obese adolescents.

Reduced Serum Levels of Zinc and Superoxide Dismutase in Obese Individuals

“…We found that Zn level was lower in obese subjects, while the level of Cu was higher. Moreover, we found that the level of SOD was decreased in the obese group, indicating Zn and SOD deficiencies in obese subjects, which is line with the previous observation [7,8,28,30,31] .…”

Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials

“…Finally, 14 RCTs met the inclusion criteria and were included in the meta-analysis. 13, 19, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38 In the included 14 trials, 5 RCTs analyzed leptin, 19, 30, 31, 34, 36 10 analyzed adiponectin, 13, 28, 29, 31, 32, 34, 35, 36, 38 2 analyzed resistin, 31, 36 and only 1 visfatin. 33 …”

“…The youths were overweight/obese 28, 29, 31, 33, 34, 37 or obese. 13, 19, 27, 30, 35, 36, 38 Three studies included only boys 28, 32, 37 and three only girls, 33, 34, 35 and the remaining studies included both boys and girls. 13, 19, 27, 29, 30, 31, 36, 38 Participants in three studies were children (6–12 years old), 28, 29, 31 in eight adolescents (13–17 years old), 13, 19, 32, 33, 34, 35, 36, 37, 38 and in the other both age groups were included.…”

“…13, 19, 27, 29, 34, 38 The intensity of the exercise was moderate, 29, 30, 31, 32, 35 moderate-to-vigorous, 28, 34, 36, 38 or vigorous 35 according to American College of Sports Medicine cut-offs recommendations. 26 Finally, adherence to the exercise programs was only reported in one study 34 (90%).…”

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

“…In a 3-year longitudinal study, higher concentrations of A-FABP and lower levels of adiponectin were reported as predictors for the development of CVD risk factors [21]. The improvement of adiponectin levels after an exercise-based intervention programme has been associated with improvements in the oxidant status in paediatric populations [68].…”