Interdependence of routes excreting manganese

Bertinchamps, AJ; Miller, S. M.; Gc, Cotzias

doi:10.1152/ajplegacy.1966.211.1.217

Cited by 115 publications

(74 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mn deficiency was observed as early as 6 weeks of age, with reduced red blood cell MnSOD levels observed in ffe/+ mice compared to +/+ control mice across all age groups studied. In addition, our study shows that Fpn provides neuroprotection against Mn toxicity and confirms loss of Mn homeostasis is tightly maintained by the liver, which is responsible for excreting excess metal into bile (39). After intestinal absorption, Mn is delivered to the liver via portal circulation, providing a protective mechanism against toxicity (42).…”

Section: Discussionsupporting

confidence: 64%

Ferroportin deficiency impairs manganese metabolism in flatiron mice

Seo

Wessling‐Resnick

2015

FASEB j.

View full text Add to dashboard Cite

We examined the physiologic role of ferroportin (Fpn) in manganese (Mn) export using flatiron (ffe/+) mice, a genetic model of Fpn deficiency. Blood (0.0123 vs. 0.0107 mg/kg; P = 0.0003), hepatic (1.06 vs. 0.96 mg/kg; P = 0.0125), and bile Mn levels (79 vs. 38 mg/kg; P = 0.0204) were reduced in ffe/+ mice compared to +/+ controls. Erythrocyte Mn-superoxide dismutase was also reduced at 6 (0.154 vs. 0.096, P = 0.0101), 9 (0.131 vs. 0.089, P = 0.0162), and 16 weeks of age (0.170 vs. 0.090 units/mg protein/min; P < 0.0001). 54 Mn uptake after intragastric gavage was markedly reduced in ffe/+ mice (0.0187 vs. 0.0066% dose; P = 0.0243), while clearance of injected isotope was similar in ffe/+ and +/+ mice. These values were compared to intestinal absorption of 59 Fe, which was significantly reduced in ffe/+ mice (8.751 vs. 3.978% dose; P = 0.0458). The influence of the ffe mutation was examined in dopaminergic SH-SY5Y cells and human embryonic HEK293T cells. While expression of wild-type Fpn reversed Mn-induced cytotoxicity, ffe mutant H32R failed to confer protection. These combined results demonstrate that Fpn plays a central role in Mn transport and that flatiron mice provide an excellent genetic model to explore the role of this exporter in Mn homeostasis.-Seo, Y. A., Wessling-Resnick, M. Ferroportin deficiency impairs manganese metabolism in flatiron mice. FASEB J. 29, 2726-2733 (2015). www.fasebj.org

show abstract

Section: Discussionsupporting

confidence: 64%

Ferroportin deficiency impairs manganese metabolism in flatiron mice

Seo

Wessling‐Resnick

2015

FASEB j.

View full text Add to dashboard Cite

show abstract

“…There is, however, increased faecal loss through intestinal secretion (2). There is an apparently important enterohepatic circulation and a mixed degree of hepatic damage (raised bilirubin and/or elevated transaminases) was observed in some patients and may account for some manganese retention.…”

Section: Discussionmentioning

confidence: 99%

Manganese Balance Studies in Infants after Operations on the Heart

1983

View full text Add to dashboard Cite

Summarywith 8-hydroxyquinoline followed by flame atomic absorption spectroscopy. A higher manganese content was found in either whole Manganese balance studies have been performed on 16 infants, blood (710 f 320 nmole-litre-') or purified plasma protein (1130 aged 3 days to 8 months, in the period following operation for the f 770 nmole-litre-') compared with fresh frozen plasma (215 a correction of congenital heart defects. Samples were analyzed by 35 nmole*litre-') used in intravenous drips. The manganese conflameless atomic absorption spectroscopy or by solvent extraction tent of the milks used in oral feeding was 200-300 nmole-litre-'.

show abstract

“…The concentrations of many trace elements (Zn, Mn, Fe, Cu) in soft tissues, except in the organs concerned with storage functions (e.g., liver), can be expected to be relatively constant in ruminants, as homeostatic mechanisms control their absorption, uptake and excretion (Berlinchamps et al 1966;Underwood 1977;Sonsma et al 1981;Suttle et al 1982;Williams 1985). For some trace elements, such as Se, an increase in intake is always associated with an increase in soft tissue levels (White 1977).…”

Section: Introductionmentioning

confidence: 99%

Effect of Co, Cu, Fe, Mn, Mo, Se, and Zn supplementation on the elemental content of soft tissues and bone in sheep grazing ryegrass/white clover pasture

Grace¹,

Lee²

1990

New Zealand Journal of Agricultural Research

View full text Add to dashboard Cite

, and Mn (l05-455) on the concentrations of major and minor elements in some organs, soft tissues, and bones of 72 Romney wethers were measured. The treatment and two control groups were each made up of six sheep. Trace elements were administered daily for 84 days and the sheep grazed as one group on ryegrass/white clover pasture. The animals were then shorn and slaughtered, and some organs, tissue, and bones removed for elemental analyses. A 40% increase in liver Cu occurred when Cu intakes were increased. The Se contents of the liver, kidney, and plasma were increased by over 200% and wool by 23% with increased Se intake. Similarly, increased Mn intakes increased the Mn contents of the liver, kidney, spleen, brain, and pancreas by over 25% and the gut by 260%, and increased Fe intakes increased the Fe contents of the lungs, spleen, and gut by 30, 57, and 76% respectively. Iron also decreased the Cu contents in the carcass (27%) and, markedly, in the liver (45%). Bone mineral concentrations were influenced by increasing the intakes of Se, Mo, and Cu. The Mo and Se contents of the scapula, humerus, ulna/radius, and rib were increased by over 220 and 35% respectively with increased Mo and Se intakes, and the Ca, P, Mg and Na concentrations of the bone were elevated 16--23, 17-34, 19-27, and 8-18% respectively depending on the particular bone when supplementary Cu was given.

show abstract

Interdependence of routes excreting manganese

Cited by 115 publications

References 0 publications

Ferroportin deficiency impairs manganese metabolism in flatiron mice

Ferroportin deficiency impairs manganese metabolism in flatiron mice

Manganese Balance Studies in Infants after Operations on the Heart

Effect of Co, Cu, Fe, Mn, Mo, Se, and Zn supplementation on the elemental content of soft tissues and bone in sheep grazing ryegrass/white clover pasture

Contact Info

Product

Resources

About