Manganese Balance Studies in Infants after Operations on the Heart

Abstract

Summarywith 8-hydroxyquinoline followed by flame atomic absorption spectroscopy. A higher manganese content was found in either whole Manganese balance studies have been performed on 16 infants, blood (710 f 320 nmole-litre-') or purified plasma protein (1130 aged 3 days to 8 months, in the period following operation for the f 770 nmole-litre-') compared with fresh frozen plasma (215 a correction of congenital heart defects. Samples were analyzed by 35 nmole*litre-') used in intravenous drips. The manganese conflameless atomic absorption spectroscopy or by solvent extraction tent of the milks used in oral feeding was 200-300 nmole-litre-'.

Nutrient Requirements For Preterm Infant Formulas

“…Healthy, breast-fed term infants (n ϭ 10) excreted an average of 0.07 g of urinary manganese/kg on the sixth to the eighth day of life (Widdowson, 1969). Daily urinary excretion of manganese in surgically stressed term infants (n ϭ 3) was higher, averaging 2.7-8.9 g/kg during the first 11-12 days of life (Sampson et al, 1983). Preterm-LBW infants (n ϭ 11) infused with 40 g/kg of manganese in TPN, however, excreted an average of 0.35 g of manganese/d in urine, little more than the 0.1 g/d excreted by those receiving TPN that was not supplemented with manganese (n ϭ 2) (Friel et al, 1988).…”

“…At 1 week of age, 11 healthy term infants fed breast milk excreted at least five times more manganese in the feces than they consumed in milk, leading to a negative balance (Widdowson, 1969). Likewise, surgically stressed term infants (n ϭ 3) remained in negative balance (-14.7 to -63.2 g/kg) for at least the first 11-12 days postpartum, excreting two to four times as much manganese in feces as consumed orally (Sampson et al, 1983). At about 2 weeks postpartum, 43% (three of seven) of manganese balance studies in healthy, breast-fed term infants were negative (Dörner et al, 1989).…”

Modeling Manganese Kinetics for Human Health Risk Assessment

“…ingestion of high Mncontent food such as formula milk. [73][74][75][76][77] This age-and dose-dependent control of biliary excretion is described in the model (Figure 13.8). Since we had dose-dependent biliary excretion controlled by blood Mn in the model, it is critical to take into account the elevated basal blood concentration in infants and children compared to the adult to depict this key homeostatic mechanism.…”