Interactions of C12 surfactants with the skin: Changes in enzymes and visible and histological features of rat skin treated with sodium lauryl sulphate

Gibson, Walter T.; Teall, Martin

doi:10.1016/0278-6915(83)90145-x

Cited by 29 publications

(4 citation statements)

References 9 publications

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“…Barrier disruption can have an effect beyond the SC, directly impacting cellular function in the viable epidermis [ 39,57,58 ] . It is expected that both chemical and biochemical insults will have a greater infl uence on cellular functions than would mechanical insults such as abrasion.…”

Section: Implications For Future Researchmentioning

confidence: 99%

Impact of Stratum Corneum Damage on Natural Moisturizing Factor (NMF) in the Skin

Kroll

Hoffman

Cunningham

et al. 2012

Treatment of Dry Skin Syndrome

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Section: Implications For Future Researchmentioning

confidence: 99%

Impact of Stratum Corneum Damage on Natural Moisturizing Factor (NMF) in the Skin

Kroll

Hoffman

Cunningham

et al. 2012

Treatment of Dry Skin Syndrome

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“…Anionic surfactants, for instance, better enhance the skin penetration ability of target molecules, exerting a more powerful interaction with keratin and lipids [43,[48][49][50][51]. Additionally, sodium lauryl sulfate (SLS) alkyl chains were reported to be involved in the hydrophobic interaction with skin structures, exposing the end sulphate group of the surfactant, creating additional bonding sites in the membrane, thus leading to increased skin hydration [52,53].…”

Section: Surfactantsmentioning

confidence: 99%

Nanoemulsion: A Review on Mechanisms for the Transdermal Delivery of Hydrophobic and Hydrophilic Drugs

et al. 2019

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Nanoemulsions (NEs) are colloidal dispersions of two immiscible liquids, oil and water, in which one is dispersed in the other with the aid of a surfactant/co-surfactant mixture, either forming oil-in-water (o/w) or water-in-oil (w/o) nanodroplets systems, with droplets 20–200 nm in size. NEs are easy to prepare and upscale, and they show high variability in their components. They have proven to be very viable, non-invasive, and cost-effective nanocarriers for the enhanced transdermal delivery of a wide range of active compounds that tend to metabolize heavily or suffer from undesirable side effects when taken orally. In addition, the anti-microbial and anti-viral properties of NE components, leading to preservative-free formulations, make NE a very attractive approach for transdermal drug delivery. This review focuses on how NEs mechanistically deliver both lipophilic and hydrophilic drugs through skin layers to reach the blood stream, exerting the desired therapeutic effect. It highlights the mechanisms and strategies executed to effectively deliver drugs, both with o/w and w/o NE types, through the transdermal way. However, the mechanisms reported in the literature are highly diverse, to the extent that a definite mechanism is not conclusive.

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“…Histological studies of chemical damage to the skin have focused primarily on surfactants and solvents. Gibson and Teal (1983) showed that rat skin treated with sodium lauryl sulphate resulted in release of acid phosphatase and lactate dehydrogenase which was accompanied by erythema and edema. Rutherford and Pawlowski (1974) exposed volunteers to two detergent solutions containing dodecyl benzene sulphonate.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory damage to skin by prolonged contact with 1,2-dichlorobenzene and chloropentafluorobenzene

McDougal

Grabau

Dong

et al. 1997

Microsc. Res. Tech.

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Interactions of C12 surfactants with the skin: Changes in enzymes and visible and histological features of rat skin treated with sodium lauryl sulphate

Cited by 29 publications

References 9 publications

Impact of Stratum Corneum Damage on Natural Moisturizing Factor (NMF) in the Skin

Impact of Stratum Corneum Damage on Natural Moisturizing Factor (NMF) in the Skin

Nanoemulsion: A Review on Mechanisms for the Transdermal Delivery of Hydrophobic and Hydrophilic Drugs

Inflammatory damage to skin by prolonged contact with 1,2-dichlorobenzene and chloropentafluorobenzene

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