Inflammatory damage to skin by prolonged contact with 1,2-dichlorobenzene and chloropentafluorobenzene

Influence of short‐term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals

“…The dermal uptake of VOCs occurs via diffusion into the skin. Once VOCs have penetrated the cornified layer, they can damage the viable epidermis and dermis and cause erythema, oedema, leucocyte infiltration, necrosis and increased oxidative species and low‐molecular‐weight DNA levels in rat skin [29, 30].…”

Influence of short‐term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals

“…The dermal uptake of VOCs occurs via diffusion into the skin. Once VOCs have penetrated the cornified layer, they can damage the viable epidermis and dermis and cause erythema, oedema, leucocyte infiltration, necrosis and increased oxidative species and low‐molecular‐weight DNA levels in rat skin [29, 30].…”

Comparative Study of Molecular Mechanisms of Skin Irritation After Acute Exposure to m-XYLENE in Rats and Guinea Pigs

“…Our aim is to detect and quantify the time course of early molecular biological events that occur in skin irritation. Although rats and guinea pigs are preferred animals for testing skin irritancy, considerable variations in irritancy response between animal species has been reported (Davies et al, 1972;McDougal et al, 1997). In rats and guinea pigs, organic chemicals like 1,2-dichlorobenzene and chloropentafluorobenzene caused damage to the skin after exposure.…”

Influence of short‐term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals

“…The dermal uptake of VOCs occurs via diffusion into the skin. Once VOCs have penetrated the cornified layer, they can damage the viable epidermis and dermis and cause erythema, oedema, leucocyte infiltration, necrosis and increased oxidative species and low‐molecular‐weight DNA levels in rat skin [29, 30].…”

Comparative Study of Molecular Mechanisms of Skin Irritation After Acute Exposure to m-XYLENE in Rats and Guinea Pigs

“…Our aim is to detect and quantify the time course of early molecular biological events that occur in skin irritation. Although rats and guinea pigs are preferred animals for testing skin irritancy, considerable variations in irritancy response between animal species has been reported (Davies et al, 1972;McDougal et al, 1997). In rats and guinea pigs, organic chemicals like 1,2-dichlorobenzene and chloropentafluorobenzene caused damage to the skin after exposure.…”

Influence of short‐term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals

“…The dermal uptake of VOCs occurs via diffusion into the skin. Once VOCs have penetrated the cornified layer, they can damage the viable epidermis and dermis and cause erythema, oedema, leucocyte infiltration, necrosis and increased oxidative species and low‐molecular‐weight DNA levels in rat skin [29, 30].…”

Comparative Study of Molecular Mechanisms of Skin Irritation After Acute Exposure to m-XYLENE in Rats and Guinea Pigs

“…Our aim is to detect and quantify the time course of early molecular biological events that occur in skin irritation. Although rats and guinea pigs are preferred animals for testing skin irritancy, considerable variations in irritancy response between animal species has been reported (Davies et al, 1972;McDougal et al, 1997). In rats and guinea pigs, organic chemicals like 1,2-dichlorobenzene and chloropentafluorobenzene caused damage to the skin after exposure.…”