Interactions Between Immune System Parameters and Thyroid Status in People From Radioactive Contaminated Areas by the Conditions of Emotional Stress

Sokolenko, V. L.; Sokolenko, S. V.

doi:10.15407/fz63.03.032

Cited by 5 publications

(7 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our previous studies, typical signs of stress reactions among individuals aged 18-24 years old who lived on the territory of enhanced radiation control were marked, in particular, raised level of cortisol (Sokolenko & Sokolenko, 2015), which increased further in conditions of additional psycho-emotional stress (Sokolenko, 2015). As a result, signs of immunosuppression were observed in this group, which were accompanied by an imbalance of thyroid status and lipid metabolism, changes in oxidative and antioxidant activity (Sokolenko & Sokolenko, 2015, 2017a2017b;Sokolenko 2016).…”

Section: Introductionmentioning

confidence: 78%

“…It is known that the thyroid gland takes part in the development of oxidative stress by stimulating several enzyme systems (De Vito et al, 2011), we also indicate the possibility of the impact of this phenomenon on immune cells proliferation and migration of (Barreiro et al, 2011). In our previous reports, the relationship between the thyroid status of individuals from radiation-contaminated territories, their lipid profiles and the immune system was characterized (Sokolenko & Sokolenko, 2017a, 2017b.…”

Section: Correlation Coefficientmentioning

confidence: 99%

See 1 more Smart Citation

Interconnection of the immune system and the intensity of the oxidative processes under conditions of prolonged exposure to small doses of radiation

Sokolenko

Шейко

et al. 2018

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

This research studied the interrelationship between the immune and oxidative-antioxidant systems in a group of individuals who had lived for a long time in areas contaminated with radionuclides after the Chernobyl catastrophe and as a result experienced prolonged exposure to small doses of ionizing radiation. We have examined a group of 100 students aged 18–24, where 50 of them formed the control group and the remaining 50 belonged to the experimental group as they arrived from the territories of enhanced radioecological control (IV radiation zone, density of soil contamination by isotope 137Cs 3.7 x 104 – 18.5 x 104 Bq/m2). Here we determined the level of cortisol, leukocytes and their populations, the levels of lymphocyte subpopulations with phenotypes CD3+, CD5+, CD4+, CD8+, CD16+, CD72+, immunoregulatory index CD4+/CD8+, indicators of phagocytic activity of neutrophils and monocytes, IgG (H), IgM (H), IgA (H), malondialdehyde (MDA), ceruloplasmin (CP), transferrin (Tr), sulfhydryl (SH); and also calculated the oxidative stress index (OSI). We performed the analysis twice: in the absence/presence of additional emotional stress such as an examination session. The studies showed an increase in the oxidative stress index in the group examined from the experimental cluster, especially in terms of emotional stress. At the same time, the neutrophil level increased, but phagocytic activity of neutrophils and monocytes, the relative and absolute number of lymphocytes with phenotypes CD3+, CD5+, CD4+, CD4+/CD8+, and IgG levels decreased. Consequently we revealed the negative correlation between the indexes of oxidative stress in the group of examined (the oxidative stress index (ISO)/the level of malonic dialdehyde (MDA)) and the parameters of phagocytic activity of monocytes, the immunoregulatory index CD4+/CD8+, and the number of lymphocytes with the CD16+ phenotype. In this study we demonstrated the decrease in the participation of ceruloplasmin (CP) as an important antioxidant factor in maintaining the immune homeostasis of the group examined from radiation-contaminated areas compared with control group. The evidence of this is the lack of reliable correlation between ceruloplasmin level and immune system parameters. Moreover we found that radiation-induced intensification of oxidative processes in the experimental group grew in conditions of additional stresses of an emotional nature. Besides, it was accompanied by a significant correlation in the level of oxidative stress and phagocytic activity parameters. Reducing phagocytic activity and the CD4+/CD8+ index on the background of oxidative stress increase can be considered as a sign of immune system ageing, while a decrease in the number of lymphocytes with the CD16+ phenotype is a sign of antitumor defense inhibition. Thus, we draw the conclusion that the inhabitants of the territories of strengthened radioecological control, undergoing exposure to small doses of ionizing radiation from birth, show a significant imbalance of redox homeostasis, which creates the preconditions for immunoreactivity pathology development at the level of both innate and acquired immunity.

show abstract

Section: Introductionmentioning

confidence: 78%

Section: Correlation Coefficientmentioning

confidence: 99%

Interconnection of the immune system and the intensity of the oxidative processes under conditions of prolonged exposure to small doses of radiation

Sokolenko

Шейко

et al. 2018

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

show abstract

“…Previously, we showed that the students in the experimental group during the intersession period had immune system indicators within the homeostatic norm, although, in terms of cells with phenotypes CD3+, CD5+, CD4+, CD16+ and index CD4+/CD8+ they were significantly lower than control values (Sokolenko & Sokolenko, 2017a;Sokolenko et al, 2018). This could be a sign of the allostasis effect -a set of biological processes designed for dynamic stabilization under conditions of adaptation to environmental requirements, when, unlike homeostasis, parameters do not necessarily return to their initial levels, while remaining within the reference range values (Cool & Zappetti, 2019).…”

Section: Discussionmentioning

confidence: 75%

“…In particular, 48 people had signs of moderate hyperthyroidism, 21 -signs of moderate hypothyroidism. Previous studies have shown that individuals with signs of thyroid dysfunction had more pronounced differences of immune system parameters compared to control, especially at the level of T-cell immunity (Sokolenko & Sokolenko, 2017a). The calculated relative risks for the subgroups of hyperthyroidism and hypothyroidism showed that in both cases their statistical significance is evident (P < 0.05), the statistical significance of the differences of qualitative characteristics in the groups, although, in the state of hypothyroidism, the relative risk of going beyond the lower limit of immunoregulatory rate is 1.28 times higher than in the hyperthyroidism group.…”

Section: Discussionmentioning

confidence: 97%

“…During the additional emotional load (examination session period) a considerable share of the analyzed indicators shifted to their homeostatic limits, many of the examined had an immunoregulatory index CD4+/CD8+ beyond the lower limit, which was caused by a significant decrease in the level of functionally mature T lymphocyte with CD4+ phenotype (Sokolenko & Sokolenko, 2017a;Sokolenko et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Manifestations of allostatic load in residents of radiation contaminated areas aged 18–24 years

Sokolenko¹,

Sokolenko²

2019

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

We studied the features of allostatic load (AL) in 100 students aged 18–24 years old who, from birth to adulthood, lived in the territories assigned to the IV radiation zone after the Chornobyl accident (density of soil contamination by isotopes 137Cs 3.7–18.5∙104 Bq/m2) and underwent prolonged exposure to small doses of ionizing radiation. The examined students did not have any clinical signs of the immune-neuroendocrine system dysfunction. 50 people had signs of vegetative-vascular dystonia syndrome (VVD), 48 had signs of moderate hyperthyroidism and 21 had signs of moderate hypothyroidism. During the examination session, as a factor of additional psycho-emotional load, in 66 of the examined the immunoregulatory index CD4+/CD8+ went below the lower limit of the homeostatic norm, in 62 of the examined low density lipoprotein cholesterol (LDL-C) exceeded the upper level. The relative risk (RR) and attributable risk (AR) of the participation of potential secondary factors of allostatic load formation in CD4+/CD8+ immunoregulatory index going below the lower limit were calculated. The presence of statistically significant relative risk of participation in the formation of suppression of the index CD4+/CD8+: the state of hyperthyroidism, state of hypothyroidism, vegetative-vascular dystonia syndrome, higher than normal LDL-C. When the examined students combined the signs of hyperthyroidism, vegetative-vascular dystonia syndrome and higher level of LDL-C; with combination of signs of hypothyroidism, vegetative-vascular dystonia syndrome and higher level of LDL-C. The attributable risk in all cases exceeded 0.10, which confirmed the importance of some of these factors and their complexes in the formation of the effect of reduced immunoregulatory index. The CD4+/CD8+ index can be considered an important biomarker of AL and premature age-related changes in the immune system in residents of radiation-contaminated areas. The risk of AL formation in the case of occurrence of a complex of mediated secondary biomarkers (vegetative-vascular dystonia syndrome, thyroid dysfunction, hypercholesterolemia) is higher compared to their individual significance.

show abstract

The Correlation Between Iron Metabolism Indexes and Thyroid Homeostasis in Children With Sideropenia and Iodine Deficiency

Шаламай¹,

Zayats²,

Voronych-Semchenko³

2021

Fiziol Zh

View full text Add to dashboard Cite

Relationships between the iron metabolism indexes and thyroid homeostasis in children were investigated. For that purpose, 68 healthy children aged 6 to 11 years were examined (35 boys and 33 girls) with adequate iron and iodine supply (n =16), latent sideropenia (n = 16), mild iodine deficiency (n = 18) and combination of latent iron deficiency and mild iodine deficiency (n = 18). We found that in 13% of boys with latent sideropenia, 78% of boys and as many girls with mild iodine deficiency, 90% of boys and 88% of girls with combined iodine and iron deficiency, the thyroid-stimulating hormone (TSH) level in blood serum ranged from 2.5 to 4.2 mIU/l under the reference data of free triiodothyronine (fT3) and thyroxine (fT4). This observation points for development of minimal thyroid insufficiency (MTI). According to the TSH/fT4 index, MTI was found in 30% of boys and 38% of girls with combined iodine and iron deficiency. These children form the group of risk for development of subclinical hypothyroidism and require mandatory individual correction of MTI by administration of potassium iodide. We found direct moderate correlations between the contents of fT3 and fT4 in serum and the hemoglobin level (Hb) in blood, between the contents of the serum iron and ferritin (r from 0.42 to 0.64). We found also an inverse moderate correlation between the serum TSH content and indexes of iron metabolism (r from –0.56 to –0.61), and a direct moderate correlation between the TSH and total serum iron-binding capacity (r = 0.54). Therefore, iron deficiency can be considered a risk factor for the development of thyroid insufficiency, which requires control of functional capacity of thyroid gland in case of iron depot depletion. The most vulnerable period for the formation of thyroid dysfunction is a prepubertal age regardless of gender. The advisability of determining the indicators of iron metabolism and its correction under conditions of latent sideropenia, mild iodine deficiency and their combination for the prevention of MTI development was justified.

show abstract

Interactions Between Immune System Parameters and Thyroid Status in People From Radioactive Contaminated Areas by the Conditions of Emotional Stress

Cited by 5 publications

References 43 publications

Interconnection of the immune system and the intensity of the oxidative processes under conditions of prolonged exposure to small doses of radiation

Interconnection of the immune system and the intensity of the oxidative processes under conditions of prolonged exposure to small doses of radiation

Manifestations of allostatic load in residents of radiation contaminated areas aged 18–24 years

The Correlation Between Iron Metabolism Indexes and Thyroid Homeostasis in Children With Sideropenia and Iodine Deficiency

Contact Info

Product

Resources

About