Interactions between drugs and four common medicinal herbs

McFadden, Roger; Peterson, Nicola

doi:10.7748/ns.25.19.65.s54

Cited by 11 publications

(5 citation statements)

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“…The plant combination is used in treating many diseases with the aims of achieving synergistic therapeutic effect, dose and toxicity reduction, and to minimize or delay the induction of drug resistance (Chou, 2006). Herbs (drugs) do sometimes interact with each other and their interactive effects include additive, antagonism and synergistic (McFadden and Peterson, 2011).…”

Section: Discussionmentioning

confidence: 99%

Antimalarial actions of Lawsonia inermis, Tithonia diversifolia and Chromolaena odorata in combination

Afolayan

Adegbolagun

Irungu

et al. 2016

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Antimalarial actions of Lawsonia inermis, Tithonia diversifolia and Chromolaena odorata in combination

Afolayan

Adegbolagun

Irungu

et al. 2016

Journal of Ethnopharmacology

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“…Although this was highly scrutinized their use still remains popular among rural populations, and thus the possible herb-drug interactions should be investigated. Herbal supplements, such as garlic, St. John ' s Wort and grapefruit elicit a wide variety of effects on drug metabolism which have been extensively reviewed (20,21,24,26,114) .…”

Section: Herbal Supplements and Remedies Not Specifi C Tomentioning

confidence: 99%

“…Owing to the large quantity of compounds, present in a herbal preparation which is often unidentifi ed, the likelihood of an interaction is much greater than that of single active ingredients (19 -21) . One cannot guarantee the concentrations, effi cacy, safety or even the authenticity of these herbal remedies due to poor regulatory guidelines surrounding them (17,21) . Furthermore, patients tend not to disclose the use of complementary medicines to their healthcare providers (20) .…”

Section: Drug-herb Interactionsmentioning

confidence: 99%

Drug interactions in African herbal remedies

Cordier

Steenkamp

2011

Dmdi

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Herbal usage remains popular as an alternative or complementary form of treatment, especially in Africa. However, the misconception that herbal remedies are safe due to their "natural" origins jeopardizes human safety, as many different interactions can occur with concomitant use with other pharmaceuticals on top of potential inherent toxicity. Cytochrome P450 enzymes are highly polymorphic, and pose a problem for pharmaceutical drug tailoring to meet an individual's specific metabolic activity. The influence of herbal remedies further complicates this. The plants included in this review have been mainly researched for determining their effect on cytochrome P450 enzymes and P-glycoprotein drug transporters. Usage of herbal remedies, such as Hypoxis hemerocallidea, Sutherlandia frutescens and Harpagophytum procumbensis popular in Africa. The literature suggests that there is a potential for drug-herb interactions, which could occur through alterations in metabolism and transportation of drugs. Research has primarily been conducted in vitro, whereas in vivo data are lacking. Research concerning the effect of African herbals on drug metabolism should also be approached, as specific plants are especially popular in conjunction with certain treatments. Although these interactions can be beneficial, the harm they pose is just as great.

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“…Therefore, it is imperative that clinical studies are performed on documented herbs to evaluate safe amounts and dose. It is also recommended that when adverse reactions are experienced with drug therapy, patients must always be queried and encourage to report of any concomitant intake of herbal products [44].…”

Section: Discussionmentioning

confidence: 99%

Common phyto-remedies used against cardiovascular diseases and their potential to induce adverse events in cardiovascular patients

Suroowan

Mahomoodally

2015

Clin Phytosci

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Cardiovascular diseases (CVDs) remain the leading cause of death globally. In addition to conventional medications, a plethora of herbal products continue to offer therapeutic alternatives to patients to assuage suffering. Nonetheless, concomitant administration of herbs and conventional medicine are not always safe which could mimic, oppose or magnify the effect of the latter leading to serious herb-drug interactions, most of which escape pharmacovigilance. The paucity of relevant information to clinicians in relation to herb-drug interactions, the inadequacy of evidence-based knowledge coupled with the lack of mechanistic facts poses a momentous threat to meet desired therapeutic outcomes in CVD patients. In this endeavor, key scientific databases have been explored to review common herbal products that might interfere clinically with conventional drugs used for CVDs and related complications. Ten common medicinal plants have been included and representative case reports whereby herbal products are thought to be inducers of adverse events are also discussed. It is anticipated that the present review will be a pinnacle of evidence and hence serve as an up-to-date fundamental repertoire of recent scientific findings to promote better understanding of adverse herb-drug events amongst clinicians and enhance rapport between clinicians and patients for subsequent counseling. Indeed, acknowledging the risks attributed to herb-drug interactions is fundamental in the management of CVDs and related implications which should not be underestimated or considered as trivial by both health-care professionals and herbal consumers.

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Interactions between drugs and four common medicinal herbs

Cited by 11 publications

References 0 publications

Antimalarial actions of Lawsonia inermis, Tithonia diversifolia and Chromolaena odorata in combination

Antimalarial actions of Lawsonia inermis, Tithonia diversifolia and Chromolaena odorata in combination

Drug interactions in African herbal remedies

Common phyto-remedies used against cardiovascular diseases and their potential to induce adverse events in cardiovascular patients

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