Interactions between Caveolin 1 polymorphism and the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) diet on Metabolic dyslipidemia in overweight and obese adult women: a cross-sectional study

Abstract

Objective: A higher incidence of metabolic dyslipidemia (MD) and its association with many diseases attracted considerable attention to its control. Caveolin 1 (CAV1) is a known gene associated with obesity. Today, a novel diet recognized as the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND( is reported to have a positive effect on overall health. Hence, we aimed to investigate the interactions between CAV1 polymorphism and MIND diet on the MD in overweight and obese patients.Results: Remarkably, there was a significant interaction between the MIND diet and CAV1 rs3807992 for dyslipidemia (β=-0.25±132, P=0.05) in the crude model. Whereby, subjects with dominant alleles had a lower risk of dyslipidemia and risk allele carriers with higher adherence to MIND diet may exhibit the lower dyslipidemia.This study presented the CAV1 gene as a possible genetic marker in recognizing people at higher risks for metabolic diseases. It also indicated that using the MIND diet may help in improving dyslipidemia through providing a probable interaction with CAV1 rs3807992 polymorphism.

The relationship of genetic risk score with cardiometabolic risk factors: a cross-sectional study

“…Previous studies showed that the MC4R variant has an association with higher BMI and WC in children and adults [55,56]. A-allele carriers of the CAV-1, which is abundant in adipocytes [25], had a significantly higher BMI [29,30]. Also, Cry − 1 has an important role in metabolism [31] and the C-allele of the Cry-1 polymorphism can lead to significantly higher obesity indices such as BMI, weight, WC, and hip circumferences [34].…”

“…Over the preceding decade, a large variety of studies have implicated CAV-1 SNP in the development of hypertension, dyslipidemia, and atherosclerosis [26][27][28]. It is worth noting that A-allele carriers of the CAV-1 rs3807992 had significantly higher BMI [29,30]. Cryptochromes (Cry) 1, the principal component of the negative limb of the core clock, appears to play important roles in metabolism [31] such as regulating glucose homeostasis [32].…”