Interactions and toxicity of non-essential heavy metals (Cd, Pb and Hg): lessons from Drosophila melanogaster

Fasae, Kehinde D.; Abolaji, Amos O.

doi:10.1016/j.cois.2022.100900

Cited by 16 publications

(11 citation statements)

References 45 publications

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“…Upon ingestion of toxic substances, the expression level of GST and P450 genes are highly up-regulated to meet the needs of converting hazardous substances into less toxic forms [ 48 , 49 ]. Excessive amounts of heavy metals, especially the non-essential metals are detrimental for organisms [ 50 ]. Insects utilize the sulfyhydryl group-containing proteins metallothioneins (Mtns) to bind and sequester free metal ions to reduce the harmful impacts, and the expression of Mtn genes are efficiently induced by heavy metals [ 51 – 53 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster

Yan

Guo

et al. 2022

J Nanobiotechnol

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Background Nanomaterials are widely used as pesticide adjuvants to increase pesticide efficiency and minimize environmental pollution. But it is increasingly recognized that nanocarrier is a double-edged sword, as nanoparticles are emerging as new environmental pollutants. This study aimed to determine the biotoxicity of a widely applied star polycation (SPc) nanocarrier using Drosophila melanogaster, the fruit fly, as an in vivo model. Results The lethal concentration 50 (LC50) value of SPc was identified as 2.14 g/L toward third-instar larvae and 26.33 g/L for adults. Chronic exposure to a sub lethal concentration of SPc (1 g/L) in the larval stage showed long-lasting adverse effects on key life history traits. Exposure to SPc at larval stage adversely impacted the lifespan, fertility, climbing ability as well as stresses resistance of emerged adults. RNA-sequencing analysis found that SPc resulted in aberrant expression of genes involved in metabolism, innate immunity, stress response and hormone production in the larvae. Orally administrated SPc nanoparticles were mainly accumulated in intestine cells, while systemic responses were observed. Conclusions These findings indicate that SPc nanoparticles are hazardous to fruit flies at multiple levels, which could help us to develop guidelines for further large-scale application.

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Section: Discussionmentioning

confidence: 99%

Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster

Yan

Guo

et al. 2022

J Nanobiotechnol

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“…Heavy metals are classified as metals with specific density more than 5 g/cm 3 which negatively impact the environment and living organisms [13]. Heavy metals can be classified into two types; essential heavy metals and non-essential heavy metals [14]. Essential heavy metals such as iron and zinc are important for human metabolism at low concentrations; however at higher concentrations, they are toxic [15].…”

Section: Introductionmentioning

confidence: 99%

“…The non-essential heavy metals, for example, cadmium (Cd), arsenic (As), lead (Pb), uranium (U), are toxic to humans even at low concentrations [14,25,26]. Cadmium is known to cause lung damage, kidney damage and fragile bones which can result in death [27,28].…”

Section: Introductionmentioning

confidence: 99%

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Toxic Heavy Metals in Soil and Plants from a Gold Mining Area, South Africa

Raji¹,

Palamuleni²

2023

Heavy Metals - Recent Advances

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The mining of mineral deposits abundant in South Africa has led to the release of toxic heavy metals into the environment. The aim of this study was to investigate heavy metal pollution from a gold mining area. The concentrations of arsenic, cadmium, lead, and zinc were analyzed in soil and plants found within 500 m and 1000 m radius of a gold mine established in North-West. The concentrations of these heavy metals were determined using Inductively Coupled Plasma Mass Spectrometry. The results showed that the concentrations of the studied heavy metals were all below the national and international threshold but higher than the concentrations found several kilometers away from the mining area, the natural background concentration. The results from the pollution load index shows that the topsoil is contaminated for the selected heavy metals. There was accumulation of the studied heavy metals in the studied Eragrostis hypnoides plant’s leaves and roots. In this study, it was revealed that zinc and cadmium bioaccumulated in the plant via the soil. These findings suggests that the consumption of agricultural products from farms within the 1 km radius of the mining site could be detrimental to the wellbeing of direct and indirect consumers.

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“…In fact, few people are aware that an increasing number of compounds containing a heavy-metal ion in a critical role are extremely useful, and several of them are used as drugs to cure or diagnose disease (1). Some heavy metals are required in trace amounts to improve enzyme function and other intracellular molecules (2). Many heavy metals (micronutrients: Cu, Zn, Fe, Mn, Mo, Ni, and Co) are essential for plants and animals when present in low concentrations in the growing medium; those that are becoming noxious only when a concentration limit is crossed (3).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and evaluation of cell culture study of mercury complex derived from benzene-1,3,5-tricarboxylic acid

Shah

2023

Preprint

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Mercury complexes have diverse effects on the human body and cells that depend upon the biochemical form of mercury-complexes and the nature of exposure. In the present work, we have investigated the impacts of mercury-complex derived from benzene-1,3,5-tricarboxylic acid on cell culture and DNA damage. This is novel mercury-complex having cell culture study. The mercury complex has been synthesized and characterized by CHNS analyzer, FTIR, X-Ray Diffraction (XRD) and DNA damage. Surface morphology of prepared mercury-complex was studied by microscopy imaging/Atomic Force Microscopy (AFM). The main goal of this contribution is to address the damaging effects of mercury-complex in cell cultures through fluorescence imaging and identifying cell Live/Death quantitative results. These live/death color intensities are red or green in presence to the mercury-complex. For this purpose, we measured the concentration dependence of mercury-complex on the rate of death in cells which may be useful for the cell culture and DNA study. The mercury-complex derived from benzene-1,3,5-tricarboxylic acid has the ability to break the polynucleotide structure of DNA to mono nucleotides resulting irreparable DNA damage. The experimental results of fluorescence microscopy and live/dead cell assay on cell viability reflected the potent cellular toxicity of mercury-complex causes cell culture study. Generally, the damaging effects of mercury-complex may be used for medical treatment of different diseases specially cancer.

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Interactions and toxicity of non-essential heavy metals (Cd, Pb and Hg): lessons from Drosophila melanogaster

Cited by 16 publications

References 45 publications

Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster

Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster

Toxic Heavy Metals in Soil and Plants from a Gold Mining Area, South Africa

Synthesis, characterization and evaluation of cell culture study of mercury complex derived from benzene-1,3,5-tricarboxylic acid

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