Mercury complexes have diverse effects on the human body and cells that depend upon the biochemical form of mercury-complexes and the nature of exposure. In the present work, we have investigated the impacts of mercury-complex derived from benzene-1,3,5-tricarboxylic acid on cell culture and DNA damage. This is novel mercury-complex having cell culture study. The mercury complex has been synthesized and characterized by CHNS analyzer, FTIR, X-Ray Diffraction (XRD) and DNA damage. Surface morphology of prepared mercury-complex was studied by microscopy imaging/Atomic Force Microscopy (AFM). The main goal of this contribution is to address the damaging effects of mercury-complex in cell cultures through fluorescence imaging and identifying cell Live/Death quantitative results. These live/death color intensities are red or green in presence to the mercury-complex. For this purpose, we measured the concentration dependence of mercury-complex on the rate of death in cells which may be useful for the cell culture and DNA study. The mercury-complex derived from benzene-1,3,5-tricarboxylic acid has the ability to break the polynucleotide structure of DNA to mono nucleotides resulting irreparable DNA damage. The experimental results of fluorescence microscopy and live/dead cell assay on cell viability reflected the potent cellular toxicity of mercury-complex causes cell culture study. Generally, the damaging effects of mercury-complex may be used for medical treatment of different diseases specially cancer.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.