Abstract:This work presents an electroanalytical method for the determination of moxifloxacin (MOXI) in tablets by its interaction with Cu(II) ion and subsequent electrochemical reduction at hanging mercury drop electrode (HMDE). A well-defined reduction peak at -0.21 V vs. Ag/AgCl in Phosphate buffer 0.04 mol L-1 pH 8.0 was observed for the complex reduction MOXI-Cu(II), using square-wave voltammetry (SWV). Using a 10 s of accumulation time at -0.40 V was found a limit detection of 3.60x10-8 mol l-1. The obtained resu… Show more
“…The solid residues above 530 and 500°C were identified as Au and Ag metal oxides, respectively. In all the complexes, the final products are metal oxides (Chawla et al 2012;Trindade et al 2006). The molar conductance of complexes in DMF (~10-3 M) was determined at 27 + 2°C using systronic 303 reading conductivity bridge for Au(III) and Ag (I) complexes of moxifloxacin.…”
Section: Thermal Behavior Of Au (Iii) and Ag (Ii) Moxifloxacin Metal mentioning
Methods: Moxifloxacin-Au(III) and Ag(I) metal complexes were prepared by adding corresponding aqueous solutions of Au(III) and Ag(I) metal salts to methanolic solution of Moxifloxacin. These metal complexes were characterized by physio-chemical techniques like UV-Vis, 1 H-NMR, FTIR, XRD, DSC, TGA, SEM and microanalytical data. The disc diffusion method was used to study the antibacterial activity of the Moxifloxacin-metal complexes.
“…The solid residues above 530 and 500°C were identified as Au and Ag metal oxides, respectively. In all the complexes, the final products are metal oxides (Chawla et al 2012;Trindade et al 2006). The molar conductance of complexes in DMF (~10-3 M) was determined at 27 + 2°C using systronic 303 reading conductivity bridge for Au(III) and Ag (I) complexes of moxifloxacin.…”
Section: Thermal Behavior Of Au (Iii) and Ag (Ii) Moxifloxacin Metal mentioning
Methods: Moxifloxacin-Au(III) and Ag(I) metal complexes were prepared by adding corresponding aqueous solutions of Au(III) and Ag(I) metal salts to methanolic solution of Moxifloxacin. These metal complexes were characterized by physio-chemical techniques like UV-Vis, 1 H-NMR, FTIR, XRD, DSC, TGA, SEM and microanalytical data. The disc diffusion method was used to study the antibacterial activity of the Moxifloxacin-metal complexes.
“…The methods employed in the literature include high-Performance Liquid Chromatography (20,21) ; square-wave voltammetry by interaction of MOX with Cu(II) (6) ; potentiometric and UV spectrophotometric measurements through complex formation with gadolinium(III) ion (22) . Recently, MOX-copper complexes were synthesized, characterized and screened for anti-proliferative and apoptosis-inducing activity against multiple human breast cancer cell lines (23) .…”
Section: Fig1 Structure Of Moxifloxacinmentioning
confidence: 99%
“…The 1 H-NMR spectra were recorded on a JEOL 500 MHz spectrometer using DMSO-d 6 as a solvent and TMS as internal standard. Mass spectra (MS) were taken on an AEIMS 30 Mass spectrometer at 70eV.…”
Section: Apparatusmentioning
confidence: 99%
“…It is available for oral and parenteral administration. IV formulation of MOX will now allow treatment of very ill hospitalized patients with respiratory or skin infections (3,5,6) .…”
PECTROSCOPIC methods such as mass, FT-IR and nuclear ........magnetic resonance in combination with thermal analysis measurements were used to verify and describe the physicochemical properties of the synthesized moxifloxacin (MOX) Zirconium (IV) metal complex. The spectroscopic and elemental analysis data support the formation of the complex with the formula C 21 H 23 FN 3 O 4 Zr(H 2 O) 2 .0.5H 2 O. Results revealed that complexation between Zirconium (IV) and moxifloxacin exhibited significant increase in antibacterial activity especially against Gram negative organisms.In addition, a simple, rapid, reliable, and sensitive spectrofluorometric method is developed for the determination of MOX. The method depends on the chelation of MOX with zirconium (IV) to produce fluorescent chelate (MOX/ Zr). Different factors affecting the relative fluorescence intensity of the resulting chelate were studied and optimized. The relationship between the concentration and relative fluorescence intensity was rectilinear in the range of 0.1-4 µg/ml. The limits of detection and quantitation are 0.06 and 0.11 µg/ ml, respectively.At the optimum reaction conditions, the drug-metal chelate showed excitation maximum at 333 nm and emission maxima at 485nm. The developed method was applied successfully for the determination of the studied drug in its pharmaceutical dosage forms with a good precision and accuracy.
“…An electroanalytical method for the determination of moxifloxacin in tablets by its interaction with Cu(II) ion and subsequent electrochemical reduction at hanging mercury drop electrode has been developed [56]. A well-defined reduction peak in phosphate buffer was observed using accumulation for the complex moxifloxacin-Cu(II), using square-wave voltammetry.…”
Section: Electrochemistry Of the Metal Ions-fluoroquinolone Complexesmentioning
This mini review describes the results regarding the voltammetric determination of micromolar, submicromolar and nanomolar concentrations of various fluoroquinolones antibacterial agents using both traditional hanging mercury drop electrode, carbon paste electrode, glassy carbon paste electrode and chemically modified electrodes. We concentrate on the interaction of quinolones with DNA in solution and at electrode surface in the context of the general development in the field.
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