Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

“…At physiological conditions, non-enveloped viruses have negatively charged capsids and enveloped viruses harbour negatively charged glycoproteins on their surface, and are thus likely directly targeted by cationic porphyrins via electrostatic interactions, like previously described for Gram(−) bacteria (Karlin and Brendel 1988;Michen and Graule 2010;Liu et al 2015). Nucleic acids can also be directly targeted by both cationic porphyrins and phthalocyanines, and PDT can induce photocleavage of both RNA and DNA viruses (Abe and Wagner 1995;Moor et al 1997;Mettath et al 1999;Zupan et al 2005;Lopez Zeballos et al 2014). Nonetheless, to what extent such intercalation and cleavage contributes to virus inhibition in comparison to other possible mechanisms is not clear (Zupan et al 2005).…”

Studies on DNA Interaction with 2(3),9(10), 16(17), 23(24)‐Tetrakis 2((4‐Phenoxyphenyl) Diazeylbenzoic acid)phthalocyaninato Zinc (II) Compound

“…According to Uslan, the study of copper hexamethyleneimino‐ethoxy substituted phthalocyanine compound showed that the compounds indicate strong DNA activities . According to another study, the results showed that zinc (II) cationic phthalocynanine compounds had a greater affinity for DNA …”

Investigation of DNA‐Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5‐Trimethoxybenzyloxy Substituents

“…[ 25] A study indicated that water‐soluble quaternized zinc and metal‐free phthalocyanines showed powerful DNA binding activity . According to Barut, studying water soluble morpholine substituted Zn(II) phthalocyanine compound showed that the compound binded to CT‐DNA through intercalation mode . The experimental results of another study showed that cationic phthalocyanine compounds binded to DNA via electrostatic interaction .…”