Interaction of a copper (II) complex containing an artificial sweetener (aspartame) with calf thymus DNA

Shahabadi, Nahid; Khodaei, Mohammad Mehdi; Kashanian, Soheila; Kheirdoosh, Fahimeh

doi:10.1016/j.saa.2013.10.008

Cited by 10 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DNA base pairs and amino sugar moiety are involved mainly in intercalative or groove binding interactions. In this respect the design of functional materials has received considerable attention due to their propensity to take part also in potential applications in DNA molecule probes [ 13 ]. Fluorescence spectroscopy measurement also helps in studying the dynamic interactions and apparition of macromolecules and macromolecular complexes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterisation of Copper(II) Complexes with Tridentate NNO Functionalized Ligand: Density Function Theory Study, DNA Binding Mechanism, Optical Properties, and Biological Application

Hazra

Dolai

Pandey

et al. 2014

Bioinorganic Chemistry and Applications

View full text Add to dashboard Cite

The photo physical properties of two mononuclear pentacoordinated copper(II) complexes formulated as [Cu(L)(Cl)(H2O)] (1) and [Cu(L)(Br)(H2O)] (2) HL = (1-[(3-methyl-pyridine-2-ylimino)-methyl]-naphthalen-2-ol) were synthesized and characterized by elemental, physicochemical, and spectroscopic methods. The density function theory calculations are used to investigate the electronic structures and the electronic properties of ligand and complex. The interactions of copper(II) complexes towards calf thymus DNA were examined with the help of absorption, viscosity, and fluorescence spectroscopic techniques at pH 7.40. All spectroscopy's result indicates that complexes show good binding activity to calf thymus DNA through groove binding. The optical absorption and fluorescence emission properties of microwires were characterized by fluorescence microscope. From a spectroscopic viewpoint, all compounds strongly emit green light in the solid state. The microscopy investigation suggested that microwires exhibited optical waveguide behaviour which are applicable as fluorescent nanomaterials and can be used as building blocks for miniaturized photonic devices. Antibacterial study reveals that complexes are better antimicrobial agents than free Schiff base due to bacterial cell penetration by chelation. Moreover, the antioxidant study of the ligand and complexes is evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assays, which demonstrate that the complexes are of higher antioxidant activity than free ligand.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterisation of Copper(II) Complexes with Tridentate NNO Functionalized Ligand: Density Function Theory Study, DNA Binding Mechanism, Optical Properties, and Biological Application

Hazra

Dolai

Pandey

et al. 2014

Bioinorganic Chemistry and Applications

View full text Add to dashboard Cite

show abstract

“…Similarly, Hoechst 33258, a groove binding dye, was used to study the Pioglitazone‐DNA interaction . Hoechst showed increased in fluorescent intensity in the presence of DNA.…”

Section: Resultsmentioning

confidence: 99%

Study on the interaction of antidiabetic drug Pioglitazone with calf thymus DNA using spectroscopic techniques

Qumaizi

Anwer

Ahmad

et al. 2018

J of Molecular Recognition

View full text Add to dashboard Cite

Pioglitazone is an antidiabetic drug used to treat type 2 diabetes mellitus. Interaction of Pioglitazone with calf thymus DNA was investigated using multispectroscopic techniques and molecular docking study. Quenching and binding constant was calculated at 3 different temperatures. The binding constant of Pioglitazone with calf thymus DNA was calculated to be 6.49 × 10 M at 293 K. The quenching mechanism was found to be a static process, and thermodynamic parameters revealed van der Waals interactions and hydrogen bonds to be the major force working in Pioglitazone-DNA interaction. Pioglitazone follows the nonintercalative mode of binding and was involved in complex formation with DNA through minor groove binding and electrostatic interactions. Experiments like KI quenching studies, dye displacement assays, Circular Dichroism (CD) spectroscopy, DNA melting study, and viscosity measurements studies supported the nonintercalative mode of binding. This was further corroborated by molecular docking studies.

show abstract

“…Aspartame has also been used in the encapsulation process to improve the properties of the payload, imparting greater stability, and improving taste, color and texture and extending storage times [20]. This technique can be used not only in food industry, but also in cosmetics, agrochemical industry and pharmaceutical industry to control the release of the drug [21].…”

Section: Properties and Application In Food And Pharmaceuticalsmentioning

confidence: 99%

“…Hence, there is growing interest in more encapsulated compositions of aspartame [23]. The structure of aspartame (carboxylate and amino groups) allows it to bind metals, and can chelate heavy metals from food, drinks and the packaging in which these products are served and stored [20].…”

Section: Properties and Application In Food And Pharmaceuticalsmentioning

confidence: 99%

Aspartame—True or False? Narrative Review of Safety Analysis of General Use in Products

et al. 2021

View full text Add to dashboard Cite

Aspartame is a sweetener introduced to replace the commonly used sucrose. It was discovered by James M. Schlatter in 1965. Being 180–200 times sweeter than sucrose, its intake was expected to reduce obesity rates in developing countries and help those struggling with diabetes. It is mainly used as a sweetener for soft drinks, confectionery, and medicines. Despite its widespread use, its safety remains controversial. This narrative review investigates the existing literature on the use of aspartame and its possible effects on the human body to refine current knowledge. Taking to account that aspartame is a widely used artificial sweetener, it seems appropriate to continue research on safety. Studies mentioned in this article have produced very interesting results overall, the current review highlights the social problem of providing visible and detailed information about the presence of aspartame in products. The studies involving the impact of aspartame on obesity, diabetes mellitus, children and fetus, autism, neurodegeneration, phenylketonuria, allergies and skin problems, its cancer properties and its genotoxicity were analyzed. Further research should be conducted to ensure clear information about the impact of aspartame on health.

show abstract

Interaction of a copper (II) complex containing an artificial sweetener (aspartame) with calf thymus DNA

Cited by 10 publications

References 36 publications

Synthesis and Characterisation of Copper(II) Complexes with Tridentate NNO Functionalized Ligand: Density Function Theory Study, DNA Binding Mechanism, Optical Properties, and Biological Application

Synthesis and Characterisation of Copper(II) Complexes with Tridentate NNO Functionalized Ligand: Density Function Theory Study, DNA Binding Mechanism, Optical Properties, and Biological Application

Study on the interaction of antidiabetic drug Pioglitazone with calf thymus DNA using spectroscopic techniques

Aspartame—True or False? Narrative Review of Safety Analysis of General Use in Products

Contact Info

Product

Resources

About