Interaction Between the Hypothalamic—Pituitary—Adrenal Axis and Behavioural Compensation Following Unilateral Vestibular Deafferentation

Gliddon, Catherine M.; Smith, Paul F.; Darlington, Cynthia L.

doi:10.1080/00016480310000520

Cited by 16 publications

(6 citation statements)

References 63 publications

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“…A number of studies have suggested that the hormone cortisol, a steroid released by the body during times of stress, affects vestibular function and the synaptic and neuronal plasticity involved in vestibular compensation [27][28][29]. This suggests the importance of explanation and education about the condition prior to commencement of active therapy to prevent the physiological effects of stress.…”

Section: Discussionmentioning

confidence: 96%

Quality-of-life for individuals with a vestibular impairment following an acquired brain injury (ABI); the clients’ perspective

et al. 2015

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Individuals who suffer a brain injury and experience vestibular symptoms as part of their overall presentation are not diagnosed in a timely manner, with individuals, their families, associates and even health professionals feeling uncertain of the legitimacy of their reported symptoms. It is important that all patients who experience an acquired brain injury are screened for vestibular impairment and, if necessary, receive vestibular rehabilitation including explanation and education.

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Section: Discussionmentioning

confidence: 96%

Quality-of-life for individuals with a vestibular impairment following an acquired brain injury (ABI); the clients’ perspective

et al. 2015

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“…Alternately altered cognition and the change of genes expression in the hippocampus could reflect changes in the brain-hypothalamic-pituitary-adrenal axis due to the chronic stressful experience, involving a stressor specifically associated to hypergravity (Del Signore et al, 2004). This hypothesis is supported by the existence of a hypothalamic-pituitary-adrenal axis activation induced by vestibular lesions (Gliddon et al, 2003a,b). Gravity changes could also alter cognitive function via modulation of brain vascular reactivity (Porte and Morel, 2011).…”

Section: Effects Of Altered Gravity On the Development Of Gravity Senmentioning

confidence: 90%

The development of vestibular system and related functions in mammals: impact of gravity

Jamon

2014

Front. Integr. Neurosci.

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This chapter reviews the knowledge about the adaptation to Earth gravity during the development of mammals. The impact of early exposure to altered gravity is evaluated at the level of the functions related to the vestibular system, including postural control, homeostatic regulation, and spatial memory. The hypothesis of critical periods in the adaptation to gravity is discussed. Demonstrating a critical period requires removing the gravity stimulus during delimited time windows, what is impossible to do on Earth surface. The surgical destruction of the vestibular apparatus, and the use of mice strains with defective graviceptors have provided useful information on the consequences of missing gravity perception, and the possible compensatory mechanisms, but transitory suppression of the stimulus can only be operated during spatial flight. The rare studies on rat pups housed on board of space shuttle significantly contributed to this problem, but the use of hypergravity environment, produced by means of chronic centrifugation, is the only available tool when repeated experiments must be carried out on Earth. Even though hypergravity is sometimes considered as a mirror situation to microgravity, the two situations cannot be confused because a gravitational force is still present. The theoretical considerations that validate the paradigm of hypergravity to evaluate critical periods are discussed. The question of adaption of graviceptor is questioned from an evolutionary point of view. It is possible that graviception is hardwired, because life on Earth has evolved under the constant pressure of gravity. The rapid acquisition of motor programming by precocial mammals in minutes after birth is consistent with this hypothesis, but the slow development of motor skills in altricial species and the plasticity of vestibular perception in adults suggest that gravity experience is required for the tuning of graviceptors. The possible reasons for this dichotomy are discussed.

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“…This was confirmed by modifications of the regulation of corticotrophin-releasing factor and arginine vasopressine in the PVN and the VN ( 56 ). The release of glucocorticoids is known to contribute to the neurochemical mechanisms of vestibular compensation ( 110 ), and agonists and antagonists of the glucocorticoid receptors accelerate and slow postural compensation, respectively ( 111 ).…”

Section: Ten Recommendations For Optimal Functional Recoverymentioning

confidence: 99%

Interaction between Vestibular Compensation Mechanisms and Vestibular Rehabilitation Therapy: 10 Recommendations for Optimal Functional Recovery

2015

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This review questions the relationships between the plastic events responsible for the recovery of vestibular function after a unilateral vestibular loss (vestibular compensation), which has been well described in animal models in the last decades, and the vestibular rehabilitation (VR) therapy elaborated on a more empirical basis for vestibular loss patients. The main objective is not to propose a catalog of results but to provide clinicians with an understandable view on when and how to perform VR therapy, and why VR may benefit from basic knowledge and may influence the recovery process. With this perspective, 10 major recommendations are proposed as ways to identify an optimal functional recovery. Among them are the crucial role of active and early VR therapy, coincidental with a post-lesion sensitive period for neuronal network remodeling, the instructive role that VR therapy may play in this functional reorganization, the need for progression in the VR therapy protocol, which is based mainly on adaptation processes, the necessity to take into account the sensorimotor, cognitive, and emotional profile of the patient to propose individual or “à la carte” VR therapies, and the importance of motivational and ecologic contexts. More than 10 general principles are very likely, but these principles seem crucial for the fast recovery of vestibular loss patients to ensure good quality of life.

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Interaction Between the Hypothalamic—Pituitary—Adrenal Axis and Behavioural Compensation Following Unilateral Vestibular Deafferentation

Cited by 16 publications

References 63 publications

Quality-of-life for individuals with a vestibular impairment following an acquired brain injury (ABI); the clients’ perspective

Quality-of-life for individuals with a vestibular impairment following an acquired brain injury (ABI); the clients’ perspective

The development of vestibular system and related functions in mammals: impact of gravity

Interaction between Vestibular Compensation Mechanisms and Vestibular Rehabilitation Therapy: 10 Recommendations for Optimal Functional Recovery

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