Interaction between lymphocytes in immune responses

Miller, J. F. A. P.; Basten, Antony; Sprent, Jonathan; Cheers, Christina

doi:10.1016/0008-8749(71)90057-8

Cited by 230 publications

(78 citation statements)

References 31 publications

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“…1 show clearly that virtually complete reconstitution of the (21,22) and in vitro (23,24). (b) The reduction in the secondary immune response resulting from the removal of T cells from sensitized lymphoid cells can be restored by much lower numbers of specifically sensitized than of normal cells or of cells sensitized to noncross-reacting antigens (16,25). This is also clearly established in the present findings showing a relative inability of normal thymus, lymph node, or spleen cells to reconstitute the depleted secondary responses to SE (26) and in vivo (27).…”

Section: Reconstitution Of Secondary Response After Depletion Of O-bementioning

confidence: 96%

Surface Antigens of Immunocompetent Cells

Mond

Takahashi

Thorbecke

1972

The Journal of Experimental Medicine

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The effect of preincubation with anti-θ or anti-mouse immunoglobulin (Ig) and complement (C') on immune responsiveness of spleen cells from BALB/c mice immunized with sheep erythrocytes (SE) was investigated. Both treatments greatly depressed the remaining ability to produce a secondary response to SE in vitro. Normal BALB/c spleen cells were far less effective in reconstituting the responses of such depleted cell populations than were much smaller numbers of untreated immune spleen cells. Thymus-derived cell (T cell) memory appeared early after immunization and showed specificity for the immunizing antigens. Recombination of anti-Ig-treated with anti-θ-treated immune spleen cells resulted in virtually complete reconstitution of responsiveness. The presence of immunological memory in T cells and the nature of their surface receptors are discussed.

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Section: Reconstitution Of Secondary Response After Depletion Of O-bementioning

confidence: 96%

Surface Antigens of Immunocompetent Cells

Mond

Takahashi

Thorbecke

1972

The Journal of Experimental Medicine

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“…Thus this factor, produced by specific T cells, had effects only on specific B cells. Because the specificity of collaborative responses in vivo (7,8) is known to be dictated by both classes of lymphocytes, it was hard to reconcile a major physiological role for a nonspecific mediator such as produced in detectable amounts in an allogeneic reaction with the known specificity of primary and secondary immune responses and immunological tolerance. Furthermore, a specific mechanism for T-B cell interaction seems more consistent with the requirement for linked recognition of T and B cell determinants (9).…”

mentioning

confidence: 99%

Cell Interactions in the Immune Response in Vitro

Feldmann

Basten

1972

The Journal of Experimental Medicine

138

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Various theories have been proposed to explain the mechanism of collaboration between thymus-derived (T) 1 and nonthymus-derived (B) lymphocytes in the induction of antibody responses. Among these is the possibility that T cells activated by antigen secrete a soluble factor capable of facilitating the induction of antibody production by B cells. In a system involving allogeneic combinations of lymphoid cells, Dutton et al. (1) in vitro and Katz et al. (2) and Kreth and Williamson (3) in vivo have obtained evidence for the release by T cells of a nonspecific factor stimulating B cell responsiveness. In these experiments T cells were activated by histocompatibility antigens, whereas the response of B cells to other antigens, such as heterologous erythrocytes or hapten-protein conjugates, was assayed. The recent demonstration by Schimpl and Wecker (4) of the production by alloantigenically stimulated T cells of a factor which could partially replace T cell function in the sheep red cell response has provided more direct evidence for the existence of a nonspecific component in T cell helper activity.In contrast, Feldmann and Basten (5, 6) have found that T cells activated by a particular antigen elaborated a factor capable of triggering syngeneic B cells, but only

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“…(Received for publication 3 December 1971) Cellular cooperation between different lymphoid cell populations is a characteristic feature of many immune responses (1,2). The classes of lymphoid cells which have been shown to collaborate have been divided into two major groups: thymus-derived (T cell) 1 and bone marrow-derived (B cell) lymphocytes.…”

mentioning

confidence: 99%

“…The classes of lymphoid cells which have been shown to collaborate have been divided into two major groups: thymus-derived (T cell) 1 and bone marrow-derived (B cell) lymphocytes. Synergism between T cell and B cell components has been demonstrated for (a) humoral responses against heterologous erythrocytes and serum proteins, (b) in "carrier-specificity" phenomena, and (c) in graft-vs.-host cell-mediated immunity (1). In addition, the demonstration of specific immunological memory and tolerance in T cell-mediated cellular responses, and in B cell-mediated humoral responses, suggests that both populations contain cells which are capable of displaying antigenic specificity (1).…”

mentioning

confidence: 99%

“…Synergism between T cell and B cell components has been demonstrated for (a) humoral responses against heterologous erythrocytes and serum proteins, (b) in "carrier-specificity" phenomena, and (c) in graft-vs.-host cell-mediated immunity (1). In addition, the demonstration of specific immunological memory and tolerance in T cell-mediated cellular responses, and in B cell-mediated humoral responses, suggests that both populations contain cells which are capable of displaying antigenic specificity (1). With respect to humoral immunity, although both classes of cells can respond to an antigenic stimulus, only the B cell line can synthesize exportable immunoglobulin (3)(4)(5).…”

mentioning

confidence: 99%

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