Interaction Between Hypertension and Diabetes Mellitus in the Pathogenesis of Sensorineural Hearing Loss

Sw, Duck; Prazma, Jiri; Ps, Bennett; Hc, Pillsbury

doi:10.1097/00005537-199712000-00004

Cited by 59 publications

(42 citation statements)

References 49 publications

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“…[9] Diabetic patients preserve a normal hearing function until diabetic neuropathy developed; since National Journal of Physiology, Pharmacy and Pharmacologythen the nerve degeneration, related to decrease in circulating nerve growth factor, leads to a progressive impairment of the auditory pathway with consequent hearing deficit. [10] A simple and non-invasive technique is brainstem evoked response audiometry (BERA) to find out early impairment of acoustic nerve and central nervous system (CNS) pathway, even in the absence of specific symptoms. BERA is a recording of the synchronized response of a large number of neurons in the lower portion of auditory pathway and can evaluate electrophysiologically any lesions from acoustic nerve to the brainstem to show subclinical variances and central neuropathy in diabetics.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of auditory evoked response among type-II diabetic individuals in central India

Batham¹,

Choudhary²,

Yousuf³

2017

Natl J Physiol Pharm Pharmacol

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Background:The Type II diabetes mellitus (DM) is characterized by hyperglycemia, as a result of damaged beta cell function, along with increase insulin resistance, either at receptor or at postreceptor levels. Neuropathies complications are the most common in diabetes, that's may lead to delayed evoked potentials in the central pathways. Aims and Objective: This study was undertaken to know the hearing status of the Type II diabetic patients and to delay development of its related complication like central neuropathy. Materials and Methods: This study evaluates central neuropathy by brainstem evoked response audiometry (BERA) in Type II DM patients. Results: We observed significant differences in BERA latencies between diabetic patients and healthy controls. There was significantly delayed Wave II, IV latency in left ear (at 80 dB) and Wave II latency in left ear, as well as Wave IV latency in right ear (at 90 dB) as compared to control. Diabetics patients with and without peripheral neuropathy there were absolute delayed latencies of Wave I, III, and V (80 dB). With relation to blood glucose, a significant difference in absolute latencies of Wave II (right ear at 90 dB), Wave IV (in right ear at 90 dB), Wave V (left ear at 80 dB), and interpeak latencies I-V (in right ear at 90 band). Conclusion: This study suggests that BERA is a simple, non-invasive procedure to detect early impairment of acoustic nerve, and central nervous system pathways, even in the absence of specific symptoms, if BERA is carried out in diabetic patients, involvement of central neuronal axis can be detected earlier.

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Section: Introductionmentioning

confidence: 99%

Evaluation of auditory evoked response among type-II diabetic individuals in central India

Batham¹,

Choudhary²,

Yousuf³

2017

Natl J Physiol Pharm Pharmacol

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“…[22] There are other co-morbidities more commonly seen in diabetic patients that may affect hearing. The study by Duck et al [23] described a synergistic effect of high blood pressure in influencing the hearing system in patients with diabetes. In Lerman-Garber et al's trial, [24] hypertension was present in 26.1%, hypertriglyceridemia in 67.4% and low HDL cholesterol in 78.3% of type 2 diabetic patients.…”

Section: Resultsmentioning

confidence: 99%

Hearing impairment in middle-aged patients with diabetes

Özkurt

Akdağ

Tuna

et al. 2016

Biotechnology & Biotechnological Equipment

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Most studies focus on elderly patients with type 2 diabetes mellitus (T2DM). There is little known about the hearing of middle-aged subjects with T2DM. The objective of this study is to evaluate hearing impairment in patients aged 40À50 years with T2DM using pure-tone audiometry and high-frequency audiometry. Forty patients with T2DM (19 males, 21 females) and 40 (20 males, 20 females) age and sex similar controls were included. All subjects completed clinical, laboratory and auditory assessments. Pure-tone audiometry auditory tests and high-frequency audiometry tests were performed in a soundproof room for each ear using the AC-40 audiometer from Interacoustics with a special earphone appropriate for high frequency. In the T2DM group, the duration of T2DM was between 5 and 15 years (7.7 § 2.4 years). At all frequencies, the thresholds of the T2DM group were higher than the control group for both right and left ears and also significant. However, the thresholds at standard frequencies (125À8000 Hz) for both group's average were lower than 20 dB-HL and were considered to be normal, and at high frequencies (9000À16,000 Hz) the T2DM group's average thresholds were higher than 20 dB-HL and considered to be a hearing loss. A Spearman's correlation test was done between the duration of T2DM and hearing thresholds. There was a mild correlation between the duration of T2DM and hearing thresholds in all frequencies. In conclusion, patients with type 2 diabetes have a high prevalence of subclinical sensorineural hearing loss. High-frequency audiometry can be used in hearing assessment screening of diabetic patients.

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“…Many authors have found an association between arterial hypertension and hearing loss (14,17,28,29) whereas others contradict these results (12,21,27) . There are few studies regarding dyslipidemia and hearing impairment.…”

Section: Discussionmentioning

confidence: 99%

Alterações auditivas associadas a complicações e comorbidades no diabetes mellitus tipo 2

Ferreira¹,

Câmara

Almeida

et al. 2013

Audiol., Commun. Res.

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OBJETIVO: Investigar a presença de alterações auditivas, representadas por diminuição do limiar audiométrico e/ou ausência de emissões otoacústicas, associadas às características gerais, complicações crônicas e comorbidades em pacientes com diabetes tipo 2. MÉTODOS: Estudo realizado em unidade de atenção secundária, em Fortaleza, de abril a julho de 2010. Amostra de 152 pacientes de 36 a 60 anos de idade, portadores de diabetes tipo 2. Analisou-se dados clínicos relacionados ao diabetes e à avaliação audiológica, composta por audiometria tonal liminar, emissões otoacústicas evocadas por estímulo transiente e emissões otoacústicas evocadas produto de distorção. RESULTADOS: O gênero feminino predominou, com 95 (62,5%) pacientes. A média de idade foi 53,4 anos. Verificou-se perda auditiva sensorioneural em 96 (63,2%) pacientes, sendo a maioria perda coclear (83,3%). Cento e catorze pacientes (75%) apresentaram ausência de emissões transientes e 120 (78,9%), ausência de emissões produto de distorção. Os homens diabéticos demonstraram 4,4 vezes mais chance de perda auditiva que as mulheres. Quanto maior o tempo da doença, maior a probabilidade de perda auditiva. Os pacientes diabéticos acima de 50 anos também apresentaram maior chance para perda auditiva. CONCLUSÃO: Das comorbidades e complicações associadas ao diabetes, o sobrepeso/obesidade constitui fator de risco para alteração auditiva, estando associado à perda auditiva e ausência de emissões transientes. Os pacientes diabéticos com sobrepeso/obesidade apresentaram três vezes mais chances de alterações na audiometria e emissões otoacústicas.

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Interaction Between Hypertension and Diabetes Mellitus in the Pathogenesis of Sensorineural Hearing Loss

Cited by 59 publications

References 49 publications

Evaluation of auditory evoked response among type-II diabetic individuals in central India

Evaluation of auditory evoked response among type-II diabetic individuals in central India

Hearing impairment in middle-aged patients with diabetes

Alterações auditivas associadas a complicações e comorbidades no diabetes mellitus tipo 2

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