Interacting effects of obesity, race, ethnicity and sex on the incidence and control of adult-onset asthma

Koebnick, Corinna; Fischer, Heidi; Daley, Matthew F.; Ferrara, Assiamira; Horberg, Michael A.; Waitzfelder, Beth; Young, Deborah Rohm; Gould, Michael K.

doi:10.1186/s13223-016-0155-8

Cited by 24 publications

(24 citation statements)

References 43 publications

(60 reference statements)

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“…However, intriguingly, logistic regression analysis demonstrated a significant positive relationship. Previous studies reported that one of the important risk factors for asthma in women is being overweight or obese [21][22][23][24][25]. Furthermore, smoking contributes to the development of asthma in men and women [26,27].…”

Section: Discussionmentioning

confidence: 99%

Relationship between the Use of Parabens and Allergic Diseases in Japanese Adults—A Cross-Sectional Study

Shimizu

Kambayashi

Tsujiguchi

et al. 2018

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It currently remains unclear whether parabens, which are preservatives added to cosmetics, shampoos, and personal care products that exhibit biocidal activities, exert allergic effects in adults. The aim of the present study was to examine the relationship between the use of parabens and the prevalence of allergic diseases in Japanese adults. This population-based cross-sectional study comprised 2005 participants aged 40 years or older living in Shika Town in Japan who answered a self-administered questionnaire on allergic diseases and the daily use of household goods. The information obtained was then analyzed to assess the exposure to parabens (response rate: 77.9%). The prevalence of nasal allergies, atopic conjunctivitis, and total allergies was significantly higher in women who used parabens. These differences remained significant after adjustments for confounding factors including age, body mass index, smoking, alcohol, exercise, sleep, income, education, and marital status. No relationship between the prevalence of atopic dermatitis and the use of parabens was observed in men or women. However, the present results demonstrated that the prevalence of nasal allergies and atopic conjunctivitis was associated with use of parabens in women, suggesting that parabens may induce allergic responses.

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Section: Discussionmentioning

confidence: 99%

Relationship between the Use of Parabens and Allergic Diseases in Japanese Adults—A Cross-Sectional Study

Shimizu

Kambayashi

Tsujiguchi

et al. 2018

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“…Various biological and nonbiological mechanisms have been proposed to explain the relationship between obesity and poor asthma control. These include decreased response to corticosteroids, the effect of some immunomodulatory adipokines, the change in pulmonary dynamics, low levels of vitamin D, and obesity-related comorbidities such as gastroesophageal reflux and depression [46,60,61]. Gastroesophageal reflux is also a common comorbidity in obese children and is responsible for worse asthma control [36].…”

Section: Should Obesity Be Taken Into Account In the Diagnosis And Fomentioning

confidence: 99%

Obesity and Asthma: Key Clinical Questions

García‐Río¹,

Alvarez-Puebla²,

Esteban-Gorgojo³

et al. 2019

J Investig Allergol Clin Immunol

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Obesity is an asthma common comorbidity and is associated not only with its development, but also with a poorer control and higher severity of it. Recent prospective evidence supports the idea that body weight gain precedes the development of asthma, but the debate is far from over. The objective of this document is to conduct a systematic review of 3 clinical questions related to asthma and obesity: 1. Obesity and asthma: the chicken or the egg? Clinical insights from epidemiological and phenotypes studies. 2. Is obesity a confounding factor in the diagnosis and management of asthma and especially in severe or difficult-to-control asthma? 3. How obese asthma subjects respond to pharmacological treatments, and to biological drugs? Do we have effective specific interventions?. Revised epidemiological, pathological and mechanistic evidence combined with data from the intervention clinical trials do not allow us to clearly state that obesity is an asthma-causative agent. However, the complexity and heterogeneity of these two illnesses make several clinical scenarios possible. Furthermore, the diagnosis of asthma in an obese patient represents an additional clinical challenge. Physicians need to be aware of the confounding effects created by the greater symptomatic perception, the alterations of lung function and the different comorbidities that the obese subjects present. A exhaustive phenotyping of the obese asthma patient should lead us to a rational therapeutic plan, including both, the pharmacological approach and anti-obesity specific therapies including a combined plan of diet and exercise and in extreme cases, bariatric surgery.

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“…В отдель-ных работах та же тенденция отмечена у мальчиков, больных бронхиальной астмой [26]. У взрослых паци-ентов ожирение встречается чаще у женщин с бронхи-альной астмой, чем у мужчин [27][28][29].…”

Section: результаты и обсуждениеunclassified

Clinical features of obesity in children with bronchial asthma

Алимова¹,

Ячейкина²

2017

Ross. vestn. perinatol. pediatr.

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Interacting effects of obesity, race, ethnicity and sex on the incidence and control of adult-onset asthma

Cited by 24 publications

References 43 publications

Relationship between the Use of Parabens and Allergic Diseases in Japanese Adults—A Cross-Sectional Study

Relationship between the Use of Parabens and Allergic Diseases in Japanese Adults—A Cross-Sectional Study

Obesity and Asthma: Key Clinical Questions

Clinical features of obesity in children with bronchial asthma

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