Intensity of cytosol expression of 8-OHdG in normal renal tubules is associated with the severity of renal fibrosis

Tsai, Jen Pi; Liou, Jia Hung; Yeh, Kun Tu; Tai, Hui Chun; Cheng, Ya Wen; Chang, Horng Rong

doi:10.4414/smw.2011.13268

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…The strong correlation between serum concentration of 8-OHdG and PASI score in patients with severe psoriasis and the correlation between 8-OHdG levels and markers of renal impairment suggest that 8-OHdG could favour the onset and/or development of renal disease in patients with psoriasis. In medical literature, there are limited data on the role of 8-OHdG in progressive renal fibrosis (59,60), hypertension associated with proteinuria (61), chronic renal failure (62), diabetes associated with proteinuria (63,64), bladder cancer (65), renal cancer (66) and urothelial carcinoma (67).…”

Section: Psoriasis Vulgaris Pasi Score ------------------------------mentioning

confidence: 99%

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

et al. 2018

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Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted on a group of 45 patients with psoriasis vulgaris and 45 control cases, monitored over a 5-year period. Alterations of renal function, albumin/creatinine ratio (ACR, mg/g) and UA/creatinine ratio (UACR, mg/mg) were determined in spontaneous urine samples. The status of related-purine derivatives was evaluated by quantification of uric acid (UA, mg/dl), adenosine deaminase (ADA, UI/mg protein), xanthine oxidase (XO, UI/mg protein) and 8-hydroxy-deoxy-guanosine levels (8-OHdG, ng/ml) in serum samples. Compared to the controls, in patients with psoriasis there was an increase in related-purine derivatives levels, which was demonstrated by the elevated serum levels of UA (5.1±0.4 vs. 5.4±1.0, P=0.066), ADA (0.14±0.08 vs. 0.29±0.12, P=0.052), XO (0.22±0.11 vs. 0.42±0.21, P=0.011) and 8-OHdG (3.1±0.05 vs. 8.3±4.7, P=0.002). The serum levels of related-purine derivatives were associated with the severity of psoriasis. In addition, there was a link between the serum levels of related-purine derivatives and markers of renal impairment. There were positive correlations between 8-OHdG and ACR (r=0.452, P=0.028) and between ADA, XO, UA, 8-OHdG and UACR (r=0.297 and P=0.032, r=0.301 and P=0.002, r=0.431 and P=0.027, r=0.508 and P=0.002) and negative correlations between UA, 8-OHdG and the estimated glomerular filtration rate (r=-0.301 and P= 0.036, r=-0.384 and P= 0.002). Thus, severe psoriasis is a risk factor for the development of renal disease.

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Section: Psoriasis Vulgaris Pasi Score ------------------------------mentioning

confidence: 99%

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

et al. 2018

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“…Urinary angiotensinogen levels were also significantly correlated with urinary α1-microglobulin, a marker of proximal tubular injury which is believed to be one of the earliest markers of tubular dysfunction 29 . Urinary excretion of 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage associated with glomerular and interstitial fibrosis 30 , is also increased in stone formers 31 . Furthermore, immunohistochemical analysis demonstrates increased 8-OHdG expression in the renal tissue adjacent to stone in subjects with nephrolithiasis 32 .…”

Section: Evidence For Impairment Of Normal Kidney Functionmentioning

confidence: 99%

Do kidney stone formers have a kidney disease?

Zisman

Evan

Coe

et al. 2015

Kidney International

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Nephrolithiasis is a highly prevalent disorder affecting approximately one in eleven people and is associated with multiple complications including hypertension, cardiovascular disease, and chronic kidney disease. Significant epidemiologic associations with chronic kidney disease and ESRD have been noted and are reviewed herein, but debate persists in the literature as to whether kidney stone formation is a pathogenic process contributing to kidney disease. Corroborating evidence supporting the presence of kidney disease in stone formers includes the variability of renal function by stone type, the positive association of stone size with renal dysfunction, the presence of markers of renal injury in the urine of even asymptomatic stone formers, and direct evidence of renal tissue injury on histopathology. Proposed pathogenic mechanisms include recurrent obstruction and comorbid conditions such as recurrent urinary tract infections and structural abnormalities. Recent work evaluating the renal histopathology of different groups of stone formers adds further granularity, suggesting variability in mechanisms of renal injury by stone type and confirming the pathogenic effects of crystal formation. Genetic abnormalities leading to stone formation including cystinuria and primary hyperoxaluria, among others, contribute to the burden of disease in the stone-forming population.Keywords kidney stone; chronic kidney disease (CKD); histopathology For many years nephrolithiasis has been viewed as a highly unpleasant nuisance by patients and doctors alike, but there had been little concern regarding long-term ramifications. Over the last several decades, however, there has been an increasing appreciation for the association of nephrolithiasis with negative long-term outcomes including cardiovascular morbidity 1 , 2 , metabolic disturbances 3 , and renal complications including chronic kidneyUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use

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“…Research has shown that 8-OHdG is increased in the tissues, serum and/or urine of patients with oxidative stress-associated diseases. [53][54][55] Damage to genetic material can be heritable and is associated with negative effects to cells, such as tumour generation.…”

Section: Resultsmentioning

confidence: 99%

Single-wall carbon nanotube-induced airway hyperresponsiveness in rats and a postulated mechanism of action

et al. 2013

RSC Adv.

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Inflammatory responses, oxidative stress, as well as fibrosis in lungs induced by a type of nano-sized carbon nanotubes (single-walled carbon nanotubes (SWCNTs)) have been investigated. However, studies examining the effects of SWCNTs on airway hyperresponsiveness (AHR) are not so numerous. We examined the effects of pulmonary exposure to SWCNTs on AHR and sought the underlying molecular mechanisms. Wistar rats were divided into four experimental groups and repeatedly administered vehicle or 0.02, 0.20 and 2.00 mg kg À1 body weight SWCNTs through the intratracheal route. We found that 0.20 and 2.00 mg kg À1 body weight SWCNTs in rats caused significant exacerbation of AHR.SWCNTs also amplified the lung protein levels of T helper 2 cytokines, immunoglobulin production in serum, profiles of immune cells in lungs, and levels of oxidative stress-related biomarkers in the airways, and exhibited airway remodelling. These results suggest that SWCNTs can exacerbate AHR in rats by enhancing airway inflammation and pulmonary oxidative stress.

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Intensity of cytosol expression of 8-OHdG in normal renal tubules is associated with the severity of renal fibrosis

Abstract: This study demonstrated that the intensity of 8-OHdG expression in NTc was associated with the severity of renal fibrosis.

Cited by 9 publications

References 21 publications

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

Do kidney stone formers have a kidney disease?

Single-wall carbon nanotube-induced airway hyperresponsiveness in rats and a postulated mechanism of action

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