Single-wall carbon nanotube-induced airway hyperresponsiveness in rats and a postulated mechanism of action

Li, Jinquan; Li, Li; Li, Xudong; Li, Rui; Yang, Xu

doi:10.1039/c3ra44168g

Cited by 8 publications

(5 citation statements)

References 65 publications

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“…Thus, in vivo animal studies have recently been conducted to investigate the biodistribution of nanomaterials, including gold nanoparticles, QDs, SWCNTs, and graphene oxide nanosheets, in different organs10111213. Neurotoxicity and developmental toxicity as well as immunotoxicity induced by some typical nanomaterials have also been demonstrated141516171819.…”

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confidence: 99%

Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma

Chen

et al. 2014

Sci Rep

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The aggravating effects of zero-dimensional, particle-shaped nanomaterials on allergic asthma have been previously investigated, but similar possible effects of one-dimensional shaped nanomaterials have not been reported. More importantly, there are no available means to counteract the adverse nanomaterial effects to allow for their safe use. In this study, an ovalbumin (OVA)-sensitized rat asthma model was established to investigate whether single walled carbon nanotubes (SWCNTs) aggravate allergic asthma. The results showed that SWCNTs in rats exacerbated OVA-induced allergic asthma and that this exacerbation was counteracted by concurrent administration vitamin E. A mechanism involving the elimination of reactive oxygen species, downregulation of Th2 responses, reduced Ig production, and the relief of allergic asthma symptoms was proposed to explain the antagonistic effects of vitamin E. This work could provide a universal strategy to effectively protect people with allergic asthma from SWCNTs or similar nanomaterial-induced aggravating effects.

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confidence: 99%

Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma

Chen

et al. 2014

Sci Rep

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“…PM 2.5 ‐induced oxidative damage was observed through the excessive production of ROS because of the imbalance between oxidative and reductive pools. With increasing ROS, GSH is reduced correspondingly, whose depletion would aggravate oxidative stress and may ultimately result in pathological changes and lead to organ dysfunction and even cell death (Li et al ., ; Ma et al ., ). The increase of ROS level and the decrease of GSH level after exposure to PM 2.5 were in a concentration‐dependent manner.…”

Section: Discussionmentioning

confidence: 96%

The toxic effects of indoor atmospheric fine particulate matter collected from allergic and non‐allergic families in Wuhan on mouse peritoneal macrophages

Yan

Guo

et al. 2015

J of Applied Toxicology

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Recent studies have shown that fine particulate matter (PM2.5) is associated with multiple adverse health outcomes and PM2.5-induced oxidative stress is now commonly known as a proposed mechanism of PM2.5-mediated toxicity. However, the association between allergic symptoms in children and exposure to PM2.5 has not been fully elucidated, particularly the role of PM2.5 on the indoor environment involved in allergy or non-allergy is unknown. The aim of the present study was to explore whether indoor PM2.5 from the homes of children with allergic symptoms had more increased risks of allergy than that of healthy ones and then compare the toxicity and inflammatory response of them. In this study, indoor PM2.5 was collected from the homes of schoolchildren with allergic symptoms and those of healthy ones respectively, and components of PM2.5 were analyzed. PM2.5-mediated oxidative damage and inflammatory response were further evaluated in mouse peritoneal macrophages based on its effects on the levels of reactive oxygen species accumulation, lipid peroxidation, DNA damage or cytokine production. It seems that oxidative stress may contribute to PM2.5-induced toxicity, and PM2.5 from the allergic indoor environment produced more serious toxic effects and an inflammatory response on mouse peritoneal macrophages than that from a non-allergic indoor environment.

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“…Mice were anesthetized with 1.0% pentobarbital sodium by i.p. injection 24 h after the last challenge, and then AHR was measured by the AniRes2005 Lung Function System (Bestlab, Beijing, China), according to the manufacturer’s instructions and previous study (Li et al 2013 ). Airway responsiveness was examined by airway compliance (Cydn) and expiratory airway resistance (R e ).…”

Section: Methodsmentioning

confidence: 99%

LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model

Zhang

Zhou

et al. 2020

J Bioenerg Biomembr

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Asthma is defined as a heterogeneous disease, usually characterized by chronic airway inflammation. Long noncoding RNAs (lncRNAs) play important roles in various biological processes. To know more about the relationships between lncRNAs and asthma, gene microarray analysis was performed to screen differentially expressed lncRNAs between the lung tissue of ovalbumin (OVA) mice and control mice. Further studies showed that downregulating differentially expressed lncRNA-AK149641 by adeno-associated virus 6 (AAV6) in OVA mice inhibited airway inflammation, with improved airway compliance and resistance, diminished infiltration of inflammatory cells, as well as less secretions of mucus, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). Moreover, the activity of nuclear factor-kappa B (NF-κB) in the lung tissue was reduced after downregulating lncRNA-AK149641. In conclusion, we proposed that downregulation of lncRNA-AK149641 attenuated the airway inflammatory response in an OVA-induced asthma mouse model, probably in association with modulation of the NF-κB signaling pathway.

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Single-wall carbon nanotube-induced airway hyperresponsiveness in rats and a postulated mechanism of action

Cited by 8 publications

References 65 publications

Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma

Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma

The toxic effects of indoor atmospheric fine particulate matter collected from allergic and non‐allergic families in Wuhan on mouse peritoneal macrophages

LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model

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