Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

Nicolae, Ilinca; Tampa, Mircea; Ene, Corina Daniela; Mitran, Cristina Iulia; Mitran, Mădălina Irina; Sârbu, Maria Isabela; Matei, Clara; Ene, C.; Georgescu, Simona Roxana

doi:10.3892/etm.2018.7053

Cited by 8 publications

(13 citation statements)

References 59 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The difference between SUA levels of cases and controls was found to be statistically significant. (p=0.011) This was in accordance with the study conducted by Gisondiet al 13 , Yilmaz et al 14 , Khan et al 15 , while contrasting results were reported by Agravatt et al 16 .and Nicolae et al 17 The higher SUA levels among patients with Psoriasis can be explained by increased rate of purine metabolism, due to the rapid epidermal turnover, leading to accumulation of uric acid which is the end product of purine degradation.…”

Section: Discussionsupporting

confidence: 83%

Evaluation of Serum Uric Acid Levels in Psoriasis Vulgaris

2020

IJPHRD

View full text Add to dashboard Cite

Aims and Objectives: To estimate and compare the Serum Uric Acid levels in Psoriasis Vulgaris patients and healthy controls and to find out any association between the Serum Uric Acid levels and severity of the psoriasis vulgaris.Methodology: Forty patients with clinically diagnosed Psoriasis Vulgaris were taken and assessed for Serum Uric Acid levels. Forty age, sex and BMI matched controls were taken and findings of both cases and controls were compared.Results: Out of 40 cases, the prevalence of hyperuricemia in Psoriasis Vulgaris patients in our study was 17.5% compared to 10% in controls. Increased SUA levels were associated with higher PASI score and higher BSA involvement. Psoriasis and PASI were found to be independent predictors of hyperuricemia. Conclusion:Serum uric acid levels offer to be a valuable biomarker in the evaluation of Psoriasis Vulgaris and its management.

show abstract

Section: Discussionsupporting

confidence: 83%

Evaluation of Serum Uric Acid Levels in Psoriasis Vulgaris

2020

IJPHRD

View full text Add to dashboard Cite

show abstract

“…The MD value of 0 was outside the 95% CI of SUA level in the three subgroups (European and American regions, Southeast Asia, and the Middle East). In seven studies (11,15,18,39,40,43,44), a significant correlation was observed between SUA levels and PASI scores, whereas five studies (27,28,34,36,42) presented contradictory results. In our study, the stratification of psoriasis patients by PASI score into the mild and moderate to severe psoriasis subgroups revealed that moderate to severe psoriasis patients from European and American regions and Southeast Asia were more likely to have hyperuricemia.…”

Section: Discussionmentioning

confidence: 93%

“…There was heterogeneity in the Middle East and Southeast Asian subgroups, but no significant differences were observed (MD 0.30, 95% CI −1.42 to 2.02, P = 0.73; MD 0.53, 95% CI −0.46 to 1.51, P = 0.29) ( Figure 3 ). Using random-effects modeling, the pooled MD of nine studies ( 10 , 17 , 26 , 30 , 38 , 40 , 42 – 44 ) in the moderate to severe psoriasis group was determined as 1.04 (95% CI 0.21–1.86, P = 0.01). There was heterogeneity in the Middle East and Southeast Asian subgroups; in the European and American area subgroups, the heterogeneity was small ( I 2 = 14%, P = 0.28).…”

Section: Resultsmentioning

confidence: 99%

“…The metaanalysis consisted of two parts based on the type of response variable. The first part included the 27 studies (10,11,(14)(15)(16)(17)(18)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) that used continuous SUA as the response variable. These studies consisted of 31,314 participants (2,951 with psoriasis and 28,363 controls).…”

Section: General Characteristics and Methodology Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis

Zhang

Liu

Sun³

et al. 2021

Front. Med.

View full text Add to dashboard Cite

Background: Our earlier meta-analysis showed that the correlation between psoriasis and hyperuricemia might be region-dependent and that hyperuricemia was more common in patients with psoriasis in Western Europe. However, no further analysis could be conducted owing to the scarcity of data.Objective: Our study aimed to further explore the association between psoriasis and hyperuricemia.Methods: Six databases (PubMed, Embase, the Cochrane Central Register of Controlled Trials, the China National Knowledge Infrastructure database, the Chinese Scientific Journals Full Text Database, and the Wanfang Data Knowledge Service Platform) were searched for studies published between January 1980 and February 2021.Results: The search strategy yielded 291 relevant studies, of which 27 observational studies were included in this analysis. Serum uric acid (SUA) levels (mean difference [MD] 0.99, 95% confidence interval [CI] 0.48–1.49, P = 0.0001) and hyperuricemia frequency (odds ratio [OR] 5.39, 95% CI 1.88–15.40, P = 0.002) were higher in the psoriasis group than in the control group, and the subgroup differences were significant. In addition, SUA levels were significantly higher in patients with moderate to severe psoriasis from European and American countries (MD 0.89, 95% CI 0.18–1.60, P = 0.01) and Southeast Asia (MD 1.79, 95% CI 0.55–3.02, P = 0.004), while no significant differences were found between the Middle East subgroup (MD 0.63, 95% CI −0.33 to 1.59, P = 0.20). Similar results were obtained from the meta-analysis of SUA levels in patients with metabolic syndrome, obesity, or a special type of psoriasis (such as arthritic or erythrodermic psoriasis).Conclusions: Our meta-analysis study provides extended data regarding the correlation between psoriasis and hyperuricemia and the differences in SUA levels between psoriasis patients and controls in Southeast Asia, the Middle East, and European and American countries. Patients with moderate to severe psoriasis in European and American countries and Southeast Asia or those with metabolic syndrome and obesity were more likely to have higher uric acid levels.Systematic Review Registration: PROSPERO, identifier: CRD42014015091.

show abstract

“…Depicting the link between related purine derivatives and renal failure, Nicolae et al (5) conducted a prospective study on a group of psoriasis vulgaris patients and presented a series of positive and negative associations between purine derivatives and renal parameters. Based on their findings, they consider that severe psoriasis is a risk factor for the development of renal disease.…”

mentioning

confidence: 99%