Precision measurements of leptonic mixing parameters and the determination of the neutrino mass hierarchy are the primary goals of the forthcoming medium-baseline reactor antineutrino experiments, such as JUNO and RENO-50. In this work, we investigate the impact of nonstandard neutrino interactions (NSIs) on the measurements of {sin 2 θ 12 , ∆m 2 21 } and {sin 2 θ 13 , ∆m 2 31 }, and on the sensitivity to the neutrino mass hierarchy, at the medium-baseline reactor experiments by assuming a typical experimental setup. It turns out that the true mixing parameter sin 2 θ 12 can be excluded at a more than 3σ level if the NSI parameter ε eµ or ε eτ is as large as 2% in the most optimistic case. However, the discovery reach of NSI effects has been found to be small, and depends crucially on the CP-violating phases. Finally, we show that NSI effects could enhance or reduce the discrimination power of the JUNO and RENO-50 experiments between the normal and inverted neutrino mass hierarchies. * Electronic address: tohlsson@kth.se † Electronic address: he.zhang@mpi-hd.mpg.de ‡ Electronic address: shunzhou@kth.se