Integrating UHPLC–MS/MS quantification and DAS analysis to investigate the effects of wine-processing on the tissue distributions of bioactive constituents of herbs in rats: Exemplarily shown for Dipsacus asper

Tao, Yi; Du, Yingshan; Li, Weidong; Cai, Baochang; Di, Liuqing; Shi, Liyun; Hu, Lihong

doi:10.1016/j.jchromb.2017.04.035

Cited by 14 publications

(7 citation statements)

References 19 publications

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“…The results are consistent with some previous studies reporting that wine processing could increase the bioavailability of the active ingredients (Huang et al, 2014;Qian et al, 2015;Tao et al, 2017). The pharmacokinetic data was changed in the CT group, which indicated that wine processing may affect absorption of the analytes.…”

Section: Discussionsupporting

confidence: 91%

Comparative pharmacokinetics study of six effective components between two dosage forms of Qixue–Shuangbu Prescription in rats by UPLC–MS/MS

Chen

Liu

Wang

et al. 2021

Biomedical Chromatography

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Qixue-Shuangbu Prescription (QSP) is an efficacious prescription for treating heart failure, myocardial ischemia and other diseases. It is composed of nine Chinese herbs.This study investigated and compared the pharmacokinetics of QSP in rats by UPLC-MS/MS between two dosage forms of traditional decoction (TD) and compound tincture (CT). Owing to the complexity of the chemicals in QSP, ginsenoside Rg1, ginsenoside Re, ferulic acid, astragaloside IV, rhein and calycosin were chosen for the pharmacokinetics study. The method established for detecting serum specimens was shown to have acceptable selectivity, linearity, lower limit of quantitation, precision, accuracy, recovery, matrix effect and stability. The peak concentration, AUC 0-t and AUC 0-∞ of ginsenoside Re, ginsenoside Rg1, ferulic acid and rhein were significantly increased after oral administration of CT (P < 0.05), the half-life of ferulic acid in the CT group was lower than that in the TD group (P < 0.05) and the half-life and AUC 0-∞ of astragaloside IV in the CT group were significantly increased (P < 0.05), which revealed that wine-processing could influence the bioavailability and the elimination of these compounds. For better clinical efficacy, we suggest that the CT dosage form of QSP should be selected.

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Section: Discussionsupporting

confidence: 91%

Comparative pharmacokinetics study of six effective components between two dosage forms of Qixue–Shuangbu Prescription in rats by UPLC–MS/MS

Chen

Liu

Wang

et al. 2021

Biomedical Chromatography

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“…Importantly, negative ion mode was used for the MS analysis of these analytes because the response was higher than that in positive ion mode. This phenomenon may be explained by the slightly acidic nature of the analytes, which form ions [M − H] − more easily than protonated ions [M + H] + . Although the same MS parameters (SRM transition: 353.0 → 190.9, 178.9) were obtained for 3‐CQA and 5‐CQA, their chromatograms could achieve base separation due to polarity differences.…”

Section: Resultsmentioning

confidence: 99%

A simple liquid chromatography coupled with tandem mass spectrometry approach for the simultaneous quantification of thirteen compounds in rats following oral administration of raw and processedFructus Xanthii: Application in a comparative pharmacokinetic study

Jiang

Liu

Xing

et al. 2019

J of Separation Science

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A simple and sensitive analysis using ultra high performance liquid chromatography with a tandem mass spectrometric system operated in selected reaction monitoring mode was developed for the determination of 11 phenolic acids, atractyloside, and carboxyatractyloside in rat plasma. The two classes of analytes were then separated on a Waters ACQUITY™ UPLC HSS T3 column (50 mm × 2.1 mm, 1.8 µm) using gradient elution with a mobile phase of 0.2% formic acid in water containing 10 mM ammonium acetate and methanol. Detection was accomplished by selected reaction monitoring scanning via an electrospray source operating in negative ionization mode. The calibration curve was linear (R2 = 0.990) over a concentration range of 1.20–3500 ng/mL, while the validated lower limit of quantification was 1.20 ng/mL. The precision varied from 0.84 to 4.62%, and the accuracy varied within ±5%. The method proved robust with sample freezing and thawing and with short‐ and long‐term sample storage. The established method was used for simultaneous quantification and was successfully used for the first time for the pharmacokinetic evaluation of 13 compounds after the intragastric administration of raw and processed Fructus Xanthii in rats. The results indicated that processing affects the absorption and metabolism of Fructus Xanthii extract. Importantly, the results also indicated the importance of processing for the clinical application of traditional Chinese medicine.

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“…In addition, the AUC 0‐t of loganin was increased in lung tissue after oral administration of the wine‐processed Dipsacus asper aqueous extracts. However, C max and AUC 0‐t values of loganin were dropped dramatically in the heart tissue, and the AUC 0‐t value of loganin was decreased in the spleen tissue in the wine‐processed group (Tao et al, 2017). In summary, in both of the raw and wine‐processed products, the AUC 0‐t and C max of the six analytes in the tissues showed this tendency: liver > kidney > heart > spleen > lung.…”

Section: Pharmacokinetics Of Loganinmentioning

confidence: 99%

“…The results showed that the different pathological states of the research objects and the different processing methods of traditional Chinese medicine will affect the pharmacokinetic behavior of the loganin in the body. In the study of the tissue distribution of loganin, the high concentration of loganin was generally found in the kidney, indicating that the kidney may be the main excretive organ of loganin (Tao et al, 2017). However, the small distribution of loganin in brain tissue may be related to the fact that loganin has more hydroxyl groups in its structure and has higher polarity, which makes it difficult to penetrate the blood–brain barrier (Li et al, 2006).…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review

Zhang

et al. 2022

Phytotherapy Research

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Iridoid glycosides (IGs) are found in many medicinal and edible plants, such as Gardenia jasminoides, Cistanche tubulosa, Eucommia ulmoides, Rehmanniae Radix, Lonicera japonica, and Cornus officinalis. Loganin, an IG, is one of the main active ingredient of Cornus officinalis Sieb. et Zucc., which approved as a medicinal and edible plant in China. Loganin has been widely concerned due to its extensive pharmacological effects, including anti‐diabetic, antiinflammatory, neuroprotective, and anti‐tumor activities, etc. Studies have shown that these underlying mechanisms include anti‐oxidation, antiinflammation and anti‐apoptosis by regulating a variety of signaling pathways, such as STAT3/NF‐κB, JAK/STAT3, TLR4/NF‐κB, PI3K/Akt, MCP‐1/CCR2, and RAGE/Nox4/p65 NF‐κB signaling pathways. In order to better understand the research status of loganin and promote its application in human health, this paper systematically summarized the phytochemistry, analysis methods, synthesis, pharmacological properties and related mechanisms, and pharmacokinetics based on the research in the past decades.

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Integrating UHPLC–MS/MS quantification and DAS analysis to investigate the effects of wine-processing on the tissue distributions of bioactive constituents of herbs in rats: Exemplarily shown for Dipsacus asper

Cited by 14 publications

References 19 publications

Comparative pharmacokinetics study of six effective components between two dosage forms of Qixue–Shuangbu Prescription in rats by UPLC–MS/MS

Comparative pharmacokinetics study of six effective components between two dosage forms of Qixue–Shuangbu Prescription in rats by UPLC–MS/MS

A simple liquid chromatography coupled with tandem mass spectrometry approach for the simultaneous quantification of thirteen compounds in rats following oral administration of raw and processedFructus Xanthii: Application in a comparative pharmacokinetic study

Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review

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