Integrated role of microRNA-30e-5p through targeting negative regulators of innate immune pathways during HBV infection and SLE

Mishra, Richa; Bhattacharya, Sanjana; Rawat, Bhupendra Singh; Kumar, Ashish; Kumar, Akhilesh; Niraj, Kavita; Chande, Ajit; Gandhi, Puneet; Khetan, Dheeraj; Aggarwal, Amita; Sato, Seiichi; Tailor, Prafullakumar; Takaoka, Akinori; Kumar, Himanshu

doi:10.1101/2020.02.29.969014

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…Recently, Mishra et al reported that microRNA(miR)-30e-5p (miR-30e) is induced by hepatitis B virus (HBV) infection and acts as a master regulator for innate immune responses. Mechanistically, miR-30e targets multiple negative regulators such as SOCS1, SOCS3, ATG5, ATG12, TRIM38, TANK, and BECN1 of innate immune signalling pathways and increases innate immune responses [99].…”

Section: Viruses Induce Host Mirnas and Control Their Alteration And Functionsmentioning

confidence: 99%

The potential use of microRNAs as a therapeutic strategy for SARS-CoV-2 infection

Stojanović²,

Yasamineh

et al. 2021

Arch Virol

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Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To date, there is no effective therapeutic approach for treating SARS-CoV-2 infections. MicroRNAs (miRNAs) have been recognized to target the viral genome directly or indirectly, thereby inhibiting viral replication. Several studies have demonstrated that host miRNAs target different sites in SARS-CoV-2 RNA and constrain the production of essential viral proteins. Furthermore, miRNAs have lower toxicity, are more immunogenic, and are more diverse than protein-based and even plasmid-DNA-based therapeutic agents. In this review, we emphasize the role of miRNAs in viral infection and their potential use as therapeutic agents against COVID-19 disease. The potential of novel miRNA delivery strategies, especially EDV™ nanocells, for targeting lung tissue for treatment of SARS-CoV-2 infection is also discussed.

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Section: Viruses Induce Host Mirnas and Control Their Alteration And Functionsmentioning

confidence: 99%

The potential use of microRNAs as a therapeutic strategy for SARS-CoV-2 infection

Stojanović²,

Yasamineh

et al. 2021

Arch Virol

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“…Hsa-miR-30e-5p has anti-tumor effects on various kinds of cancers, such as bladder cancer, nasopharyngeal carcinoma, squamous cell carcinoma of the head and neck, and non-small cell lung cancer (46)(47)(48)(49). Hsa-miR-30e-5p plays an integrated role in the regulation of the innate immune response (50,51). Hsa-miR-30e-5p plays an important role in circMET by driving immunosuppression and anti-PD1 therapy resistance (52).…”

Section: Various Clinical Trials Have Shown That Tumor Microenvironment Immune Cell Infiltration Is Critical In Predicting the Prognosis mentioning

confidence: 99%

A novel immune-related ceRNA network that predicts prognosis and immunotherapy response in lung adenocarcinoma

Gong¹,

Zhou²,

Wu³

et al. 2021

Ann Transl Med

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Background: The tumor microenvironment plays an important role in the progression and malignancy of lung adenocarcinoma and affects the immunotherapy response. There is increasing evidence that long non-coding RNAs (lncRNAs) as competing endogenous RNAs (ceRNAs) have significant functions in the development and treatment response of various kinds of cancer. This study aimed to explore the association between immune-related lncRNA-microRNA (miRNA)-messenger RNA (mRNA)-ceRNA networks, and the prognosis of and immunotherapy response in lung adenocarcinoma.Methods: RNA-sequencing (RNA-seq) and miRNA-seq data from The Cancer Genome Atlas (TCGA) were used to evaluate the infiltration of immune cells in lung adenocarcinoma samples by undertaking a single-sample gene set enrichment analysis (ssGSEA) to divide the cells into high and low immune cell infiltration groups. The differentially expressed mRNA (DEmRNA) was further analyzed by a weighted gene co-expression network analysis (WGCNA), search tool for recurring instances of neighboring genes (STRING), and Cytoscape to select hub genes. The ceRNA network was constructed using Cytoscape.Additionally, survival analyses were conducted to screen out prognostic candidate genes.Results: Seven thousand five hundred and thirty-eight mRNAs, 540 lncRNAs, and 138 miRNAs were found to be differentially expressed between the high and low immune cell infiltration groups. The two DEmRNA modules most significantly associated with immune cell infiltration were further analyzed, and four clusters, including 179 DEmRNAs, were selected based on Molecular Complex Detection (MCODE) scores. The selected DEmRNAs in the four clusters were mainly enriched in pathways involved in regulating the immune response. Ultimately, a ceRNA network of SNHG6-hsa-miR-30e-5p-CYSLTR1 was identified as being associated with the prognosis of and immunotherapy response in lung adenocarcinoma. Conclusions:The present study extends understandings of immune-related lncRNA-miRNA-mRNA-ceRNA networks and identifies novel targets and a regulatory pathway for anti-tumor immunotherapy.

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Integrated role of microRNA-30e-5p through targeting negative regulators of innate immune pathways during HBV infection and SLE

Cited by 2 publications

References 49 publications

The potential use of microRNAs as a therapeutic strategy for SARS-CoV-2 infection

The potential use of microRNAs as a therapeutic strategy for SARS-CoV-2 infection

A novel immune-related ceRNA network that predicts prognosis and immunotherapy response in lung adenocarcinoma

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