Integrated Nanogap Platform for Sub-Volt Dielectrophoretic Trapping and Real-Time Raman Imaging of Biological Nanoparticles

Ertsgaard, Christopher T.; Wittenberg, Nathan J.; Klemme, Daniel J.; Barik, Avijit; Shih, Wei-Chuan; Oh, Sang‐Hyun

doi:10.1021/acs.nanolett.8b02654

Cited by 43 publications

(41 citation statements)

References 58 publications

(93 reference statements)

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“…In addition, label-free detection of EV can be developed by exploiting the high sensitivity of nanomaterials. One study presented a nanogap-integrated plasmonic sensing platform for EV detection without a Raman probe labeling step [113]. For improving the sensitivity, they used nanogap combining sub-volt dielectrophoretic trapping and Au NPs for real-time SERS imaging.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Applications of Bionano Sensor for Extracellular Vesicles Analysis

2020

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Recently, extracellular vesicles (EVs) and their contents have been revealed to play crucial roles in the intrinsic intercellular communications and have received extensive attention as next-generation biomarkers for diagnosis of diseases such as cancers. However, due to the structural nature of the EVs, the precise isolation and characterization are extremely challenging. To this end, tremendous efforts have been made to develop bionano sensors for the precise and sensitive characterization of EVs from a complex biologic fluid. In this review, we will provide a detailed discussion of recently developed bionano sensors in which EVs analysis applications were achieved, typically in optical and electrochemical methods. We believe that the topics discussed in this review will be useful to provide a concise guideline in the development of bionano sensors for EVs monitoring in the future. The development of a novel strategy to monitor various bio/chemical materials from EVs will provide promising information to understand cellular activities in a more precise manner and accelerates research on both cancer and cell-based therapy.

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Section: Conclusion and Future Perspectivementioning

confidence: 99%

Applications of Bionano Sensor for Extracellular Vesicles Analysis

2020

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“…Since PTs are based on conductive materials, electrophoresis (EP) [81] and dielectrophoresis (DEP) [82][83][84][85][86] can be applied to transport particles from the far field to the optical near field to feed PTs [87,88]. Using this combination, no extremely long waiting time is needed when extremely low concentration solutions are used.…”

Section: Multifunctional Ptsmentioning

confidence: 99%

Plasmonic Tweezers towards Biomolecular and Biomedical Applications

Xue

Sun

2019

Applied Sciences

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With the capability of confining light into subwavelength scale, plasmonic tweezers have been used to trap and manipulate nanoscale particles. It has huge potential to be utilized in biomolecular research and practical biomedical applications. In this short review, plasmonic tweezers based on nano-aperture designs are discussed. A few challenges should be overcome for these plasmonic tweezers to reach a similar level of significance as the conventional optical tweezers.

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“…The combination of high electrical conductivity and strong plasmonic resonance at optical wavelengths in silver and gold has led to extremely compact electrooptic nanogap devices such as integrated light sources (13), photodetectors (14,15), and modulators (16,17). Additionally, the extremely high field-enhancement possible with sub-wavelength nanogaps enables very high-sensitivity spectral measurements for applications such as label-free detection of biomolecules (18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Plasmonic nanogap enhanced phase-change devices with dual electrical-optical functionality

et al. 2019

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Modern-day computers use electrical signaling for processing and storing data which is bandwidth limited and power-hungry. These limitations are bypassed in the field of communications, where optical signaling is the norm. To exploit optical signaling in computing, however, new on-chip devices that work seamlessly in both electrical and optical domains are needed. Phase change devices can in principle provide such functionality, but doing so in a single device has proved elusive due to conflicting requirements of size-limited electrical switching and diffraction-limited photonic devices. Here, we combine plasmonics, photonics and electronics to deliver a novel integrated phase-change memory and computing cell that can be electrically or optically switched between binary or multilevel states, and read-out in either mode, thus merging computing and communications technologies.

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Integrated Nanogap Platform for Sub-Volt Dielectrophoretic Trapping and Real-Time Raman Imaging of Biological Nanoparticles

Cited by 43 publications

References 58 publications

Applications of Bionano Sensor for Extracellular Vesicles Analysis

Applications of Bionano Sensor for Extracellular Vesicles Analysis

Plasmonic Tweezers towards Biomolecular and Biomedical Applications

Plasmonic nanogap enhanced phase-change devices with dual electrical-optical functionality

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