Integrated MOSFET-Embedded-Cantilever-Based Biosensor Characteristic for Detection of Anthrax Simulant

Mostafa, Salwa; Lee, Ida; Islam, Syed K.; Eliza, Sazia A.; Shekhawat, Gajendra S.; Dravid, Vinayak P.; Tulip, Fahmida S.

doi:10.1109/led.2010.2098015

Cited by 20 publications

(12 citation statements)

References 9 publications

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“…This system can be miniaturized so as to be potentially portable for point-of-care or personal diagnosis [18,19]. In addition to these methods, two free-standing piezoresistive microcantilevers of reference and sensing structures integrated with Wheatstone bridge electrical circuitry are commonly used for thermally insensitive configuration [3,20], while another method using electrical transduction by a field-effect transistor based on a silicon-on-insulator (SOI) substrate [21,22] is still under development, although it is expected to be potentially costly. In biosensing applications, the conventional dual-beam, free-standing microcantilever configuration has been extensively used for the detection of chemical interaction and biomolecular recognition in liquid environments.…”

Section: Introductionmentioning

confidence: 99%

Electrical Detection of C-Reactive Protein Using a Single Free-Standing, Thermally Controlled Piezoresistive Microcantilever for Highly Reproducible and Accurate Measurements

Yen

Lai

Hong

et al. 2013

Sensors

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This study demonstrates a novel method for electrical detection of C-reactive protein (CRP) as a means of identifying an infection in the body, or as a cardiovascular disease risk assay. The method uses a single free-standing, thermally controlled piezoresistive microcantilever biosensor. In a commonly used sensing arrangement of conventional dual cantilevers in the Wheatstone bridge circuit, reference and gold-coated sensing cantilevers that inherently have heterogeneous surface materials and different multilayer structures may yield independent responses to the liquid environmental changes of chemical substances, flow field and temperature, leading to unwanted signal disturbance for biosensing targets. In this study, the single free-standing microcantilever for biosensing applications is employed to resolve the dual-beam problem of individual responses in chemical solutions and, in a thermally controlled system, to maintain its sensor performance due to the sensitive temperature effect. With this type of single temperature-controlled microcantilever sensor, the electrical detection of various CRP concentrations from 1 μg/mL to 200 μg/mL was performed, which covers the clinically relevant range. Induced surface stresses were measured at between 0.25 N/m and 3.4 N/m with high reproducibility. Moreover, the binding affinity (KD) of CRP and anti-CRP interaction was found to be 18.83 ± 2.99 μg/mL, which agreed with results in previous reported studies. This biosensing technique thus proves valuable in detecting inflammation, and in cardiovascular disease risk assays.

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Section: Introductionmentioning

confidence: 99%

Electrical Detection of C-Reactive Protein Using a Single Free-Standing, Thermally Controlled Piezoresistive Microcantilever for Highly Reproducible and Accurate Measurements

Yen

Lai

Hong

et al. 2013

Sensors

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“…Anthrax simulants attached to the chemically treated gold-coated cantilever cause changes in the MOSFET drain current due to the bending of the cantilever which indicates the detection of anthrax simulant. Electrical properties of the anthrax stimulant are also responsible for the change in the drain current [15].Carbon monoxide detection is required for various healthcare, environmental, and engineering applications, SU-8 microcantilever has been used as a CO sensor. The cantilever based sensor has exhibited a fast response and recovery times and is fully recoverable after repeated exposures.…”

Section: Biodetection Applications Of Microcantilever Based Biosementioning

confidence: 99%

Microcantilever based Biosensor for Disease Detection Applications

Gopinath¹,

Anitha²,

Mastani³

2015

JOMB

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The fast development of micro-electromechanical system (MEMS) technology has brought many great ideas in the field of biomedical applications. A biosensor is a chemical sensing device in which a biologically derived recognition analyte coupled to a transducer to allow the quantitative development of biochemical parameter. A biosensor consists of a bio-element and a sensor-element. The bio-element may be an enzyme, antibody, living cells, tissue, etc., and the sensing element may be electric current, electric potential, and so on and specificity of analyte is the important concept in biosensor. In this paper we review the principle of microcantilever, biosensing mechanism and applications of microcantilevers for bio detection for early detection of diseases accurately. Biosensors can have a variety of biomedical, industry, and military applications. The main advantages of MEMS based sensors are specificity, portability, simplicity, high sensitivity, potential ability for real-time and on-site analysis coupled with the high speed and low cost.

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“…In this respect, Dravid et al . reported pioneer work on metal oxide semiconductor field effect transistor (MOSFET) embedded Si cantilever for biological sensing applications111213. Recently, piezotransistive transduction using AlGaN/GaN heterojunctions field effect transistor integrated onto a GaN micro-cantilever has been reported with an ultra-high relative electro-mechanical sensitivity of 8,700.…”

mentioning

confidence: 99%

“…This advanced electro-mechanical transduction allows the detection of nanogram-level explosives with high specificity using a novel surface-based photoacoustic spectroscopy technique14. To date, efficient transistor embedded MEMS have been mainly reported for devices based on inorganic materials11121314 since micromachining of advanced polymeric MEMS remains a challenge15. However, the development of cutting edge electro-mechanical transduction scheme combining the attractive features of polymers in terms of cost effectiveness, sensitivity and biocompatibility could play an important role in driving new applications.…”

mentioning

confidence: 99%

“…The advantage of the piezoelectric gate dielectric material in improving the electro-mechanical sensitivity by a factor of 18 was clearly verified through electrical characterizations before and after polarization. The devices have been realized from cost effective fabrication processes, eliminating the need for complicated etching steps and lithographic masking required in previously reported studies211112131416. Also, the high electro mechanical sensitivity obtained has allowed the development of a humidity sensor characterized by a high sensitivity (7500 ppm/%RH) and low limit of detection (0.2%).…”

mentioning

confidence: 99%

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Piezoelectric polymer gated OFET: Cutting-edge electro-mechanical transducer for organic MEMS-based sensors

Thuau

Abbas

Wantz

et al. 2016

Sci Rep

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The growth of micro electro-mechanical system (MEMS) based sensors on the electronic market is forecast to be invigorated soon by the development of a new branch of MEMS-based sensors made of organic materials. Organic MEMS have the potential to revolutionize sensor products due to their light weight, low-cost and mechanical flexibility. However, their sensitivity and stability in comparison to inorganic MEMS-based sensors have been the major concerns. In the present work, an organic MEMS sensor with a cutting-edge electro-mechanical transducer based on an active organic field effect transistor (OFET) has been demonstrated. Using poly(vinylidenefluoride/trifluoroethylene) (P(VDF-TrFE)) piezoelectric polymer as active gate dielectric in the transistor mounted on a polymeric micro-cantilever, unique electro-mechanical properties were observed. Such an advanced scheme enables highly efficient integrated electro-mechanical transduction for physical and chemical sensing applications. Record relative sensitivity over 600 in the low strain regime (<0.3%) was demonstrated, which represents a key-step for the development of highly sensitive all organic MEMS-based sensors.

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Integrated MOSFET-Embedded-Cantilever-Based Biosensor Characteristic for Detection of Anthrax Simulant

Cited by 20 publications

References 9 publications

Electrical Detection of C-Reactive Protein Using a Single Free-Standing, Thermally Controlled Piezoresistive Microcantilever for Highly Reproducible and Accurate Measurements

Electrical Detection of C-Reactive Protein Using a Single Free-Standing, Thermally Controlled Piezoresistive Microcantilever for Highly Reproducible and Accurate Measurements

Microcantilever based Biosensor for Disease Detection Applications

Piezoelectric polymer gated OFET: Cutting-edge electro-mechanical transducer for organic MEMS-based sensors

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