Integrated microsystems for controlled drug delivery

Razzacki, S. Zafar; Thwar, Prasanna K.; Yang, Ming; Ugaz, Victor M.; Burns, Mark A.

doi:10.1016/j.addr.2003.08.012

Cited by 195 publications

(96 citation statements)

References 45 publications

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“…Through this route, the drugs can break down by the acid environment of the stomach and by the intestine enzymes. Drug absorption in the digestive system is difficult and most macromolecules cannot be absorbed, which limits the effectiveness of the drug before reaching its target location [27][28][29].…”

Section: General Drug Delivery Systemsmentioning

confidence: 99%

“…The protective layer is designed to dissolve at the targeted location increasing the absorption at certain parts of the organism. Other examples include insulin injection with a needle-less injector and constant infusion pump [29].…”

Section: General Drug Delivery Systemsmentioning

confidence: 99%

“…Some drugs are unstable and strongly influenced by their administration time while traditional drug delivery methods often require repeated and gradual increase of dosages with toxic effects [6,29,35,36].…”

Section: General Drug Delivery Systemsmentioning

confidence: 99%

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Electrodeposited conductive polymers for controlled drug release: polypyrrole

Alshammary

Walsh

Herrasti

et al. 2015

J Solid State Electrochem

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Over the last 40 years, electrically conductive polymers have become well established as important electrode materials. Polyanilines, polythiophenes and polypyrroles have received particular attention due to their ease of synthesis, chemical stability, mechanical robustness and the ability to tailor their properties. Electrochemical synthesis of these materials as films have proved to be a robust and simple way to realise surface layers with controlled thickness, electrical conductivity and ion transport. In the last decade, the biomedical compatibility of electrodeposited polymers has become recognised; in particular, polypyrroles have been studied extensively and can provide an effective route to pharmaceutical drug release. The factors controlling the electrodeposition of this polymer from practical electrolytes are considered in this review including electrolyte composition and operating conditions such as the temperature and electrode potential. Voltammetry and current-time behaviour are seen to be effective techniques for film characterisation during and after their formation. The degree of take-up and the rate of drug release depend greatly on the structure, composition and oxidation state of the polymer film. Specialised aspects are considered, including galvanic cells with a Mg anode, use of catalytic nanomotors or implantable biofuel cells for a self-powered drug delivery system and nanoporous surfaces and nanostructures. Following a survey of polymer and drug types, progress in this field is summarised and aspects requiring further research are highlighted.

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Section: General Drug Delivery Systemsmentioning

confidence: 99%

Section: General Drug Delivery Systemsmentioning

confidence: 99%

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Electrodeposited conductive polymers for controlled drug release: polypyrrole

Alshammary

Walsh

Herrasti

et al. 2015

J Solid State Electrochem

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“…Micro-and nanosystems for drug delivery offer the possibility of precise dosage and time control for highly potent drugs [13,20]. There have been great advances in drug delivery devices made of biodegradable polymers.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of Growth Factors on Allograft Bone in vitro

Huang

Ryu

Ren

et al. 2008

Clin Orthop Relat Res

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Allografts are important alternatives to autografts for treating defects after major bone loss. Bone growth factors have both local autocrine and paracrine effects and regulate the growth, proliferation, and differentiation of osteoprogenitor cells. To study the effects of prolonged, continuous, local delivery of growth factors on bone growth, we developed a new microelectromechanical system (MEMS) drug delivery device. Bone marrow cells from mice were seeded on mouse allograft discs and cultured in osteogenic media with osteogenic protein 1 (OP-1) and/or basic fibroblast growth factor (FGF-2) delivered from MEMS devices for 6 weeks. We monitored bone formation by changes of bone volume using micro-CT scanning and release of osteocalcin using ELISA. The data suggest the MEMS devices delivered constant concentrations of OP-1 and FGF-2 to the media. Bone marrow cells grew on the allografts and increased bone volume. Addition of OP-1 increased bone formation whereas FGF-2 decreased bone formation. Local delivery of growth factors over a prolonged period modulated the differentiation of osteoprogenitor cells on allograft bone.

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“…This led to the development of drug delivery systems that achieve pharmacological selectivity not solely on the basis of chemical structure but also on the basis of controlled rate of drug delivery (Goldman 1982;Banerjee & Robinson, 1991). At present, controlled drug delivery technology is one of the most rapidly advancing areas of science for human health care (Langer, 1990) which are intelligent enough to respond to the behavior of the surrounding physiological environment (Razzacki et al, 2004). Many chronic medical conditions require taking specific drugs at specific dose levels on a regular/periodic basis (Polla et al, 2000) but patients often overlook, are unwilling, or are unable to take their medication during long time using of medications (Santini et al, 1998;Kuo & Violante, 2012).…”

Section: Introductionmentioning

confidence: 99%

Implantable microchip: the futuristic controlled drug delivery system

Sutradhar

Sumi

2014

Drug Delivery

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There is no doubt that controlled and pulsatile drug delivery system is an important challenge in medicine over the conventional drug delivery system in case of therapeutic efficacy. However, the conventional drug delivery systems often offer a limited by their inability to drug delivery which consists of systemic toxicity, narrow therapeutic window, complex dosing schedule for long term treatment etc. Therefore, there has been a search for the drug delivery system that exhibit broad enhancing activity for more drugs with less complication. More recently, some elegant study has noted that, a new type of micro-electrochemical system or MEMS-based drug delivery systems called microchip has been improved to overcome the problems related to conventional drug delivery. Moreover, micro-fabrication technology has enabled to develop the implantable controlled released microchip devices with improved drug administration and patient compliance. In this article, we have presented an overview of the investigations on the feasibility and application of microchip as an advanced drug delivery system. Commercial manufacturing materials and methods, related other research works and current advancement of the microchips for controlled drug delivery have also been summarized.

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Integrated microsystems for controlled drug delivery

Cited by 195 publications

References 45 publications

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Controlled Release of Growth Factors on Allograft Bone in vitro

Implantable microchip: the futuristic controlled drug delivery system

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