Intakes of coffee, tea, milk, soda and juice and renal cell cancer in a pooled analysis of 13 prospective studies

Abstract

Specific beverage intake may be associated with the risk of renal cell cancer through a diluting effect of carcinogens, alterations of hormone levels, or other changes in the renal tubular environment, but few prospective studies have examined these associations. We evaluated the associations between coffee, tea, milk, soda and fruit and vegetable juice intakes and renal cell cancer risk in a pooled analysis of 13 prospective studies (530,469 women and 244,483 men). Participants completed a validated foodfrequency questionnaire at baseline. Using the primary data, the study-specific relative risks (RRs) were calculated and then pooled using a random effects model. A total of 1,478 incident renal cell cancer cases were identified during a follow-up of 7-20 years across studies. Coffee consumption was associated with a modestly lower risk of renal cell cancer (pooled multivariate RR for 3 or more 8 oz (237 ml) cups/day versus less than one 8 oz (237 ml) cup/day 5 0.84; 95% CI 5 0.67-1.05; p value, test for trend 5 0.22). Tea consumption was also inversely associated with renal cell cancer risk (pooled multivariate RR for 1 or more 8 oz (237 ml) cups/day versus nondrinkers 5 0.85; 95% CI 5 0.71-1.02; p value, test for trend 5 0.04). No clear associations were observed for milk, soda or juice. Our findings provide strong evidence that neither coffee nor tea consumption increases renal cell cancer risk. Instead, greater consumption of coffee and tea may be associated with a lower risk of renal cell cancer. ' 2007 Wiley-Liss, Inc.

No Association Between Tea Consumption and Risk of Renal Cell Carcinoma: A Meta-analysis of Epidemiological Studies

“…Of the ten case-control studies, five were conducted in the USA/Canada (McLaughlin et al, 1984;Goodman et al, 1986;Kreiger et al, 1993;Bianchi et al, 2000;Hu et al, 2009), and the remaining five were conducted in Denmark (Mellemgaard et al, 1994), Italy (Montella et al, 2009), Uruguay (De Stefani et al, 1998), and China (Wang et al, 2012). Of the two cohort studies, one was conducted in UK (Allen et al, 2011), and the other one was conducted in the USA (Lee et al, 2007). Figure 2 shows the association between tea consumption and renal cell carcinoma risk by using a meta-analysis of all 12 studies.…”

“…Figure 1 is a flow diagram of the procedure used to identify the relevant studies. A total of 12 articles were finally included in the meta-analysis (McLaughlin et al, 1984;Goodman et al, 1986;Talamini et al, 1990;Kreiger et al, 1993;Mellemgaard et al, 1994;De Stefani et al, 1998;Bianchi et al, 2000;Lee et al, 2007;Hu et al, 2009;Montella et al, 2009;Allen et al, 2011;Wang et al, 2012).…”

“…One case-control study reported that a higher consumption of tea significantly increased the risk of renal cell carcinoma (De Stefani et al, 1998), whereas seven case-control studies showed a non-significant positive association (McLaughlin et al, 1984;Goodman et al, 1986;Talamini et al, 1990;Kreiger et al, 1993;Mellemgaard et al, 1994;Bianchi et al, 2000;Hu et al, 2009), and two case-control studies showed a nonsignificant negative association between tea consumption and renal cell carcinoma (Montella et al, 2009;Wang et al, 2012). In contrast, one prospective cohort study reported that higher tea consumption could decrease the risk of renal cell carcinoma (Lee et al, 2007), while the other cohrot study showed that there was no significant association (Allen et al, 2011). However, no meta-analysis has been published regarding the relationship between tea consumption and renal cell carcinoma risk.…”

Böbrek Hücreli Karsinomda Risk Faktörleri ve Etyoloji

“…Hafif (0-5 gr/gün), orta (15-30 gr/gün) ve yüksek (30 gr/gün üzerinde) alkol alımı ile BHK gelişim riski karşılaştırıldığında; alkol kullanımının riski erkeklerde 0,75 den 0,71'e, kadınlarda 0,67 den 0,43'e geriletmekte olduğu saptanmıştır (38). Kahve ve çay tüketimi ile BHK arasında bir ilişki saptanamamış (39) olmasının yanında ters bir ilişkinin var olduğunu bildiren çalışmalar da bulunmaktadır (40).…”

Cancer Chemoprevention by Dietary Polyphenols

“…In a pooled analysis, Lee et al combined data of 13 prospective cohorts including more than 774,000 men and women and 1478 incident renal cell cancer cases. Compared with nondrinkers, individuals who consumed ≥1 cups/day of tea had a statistically borderline significant 15% risk reduction in renal cell cancer after adjustment for body mass index, cigarette smoking, hypertension and other potential confounders [119]. All these studies were conducted in North America and West Europe and examined the effect of presumably black tea on renal cell cancer risk.…”