Cancer Chemoprevention by Dietary Polyphenols

Aly, Magda M.; Mahmoud, Amani Abd ElHamid

doi:10.5772/54945

Cited by 5 publications

(3 citation statements)

References 171 publications

(188 reference statements)

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“…In terms of health properties, many studies have demonstrated their various biological activities including anti-inflammatory, anticancer, antibacterial and antiviral properties. Specific flavonoids were described to function as antioxidants, enzyme inhibitors, epigenetic modulators or even suppressors in some signaling pathways [72,73].…”

Section: Flavonoids and Human Healthmentioning

confidence: 99%

Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review

Drețcanu

Ştirbu

Leopold

et al. 2022

Plants

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There has been a major shift in the collective mindset around the world in recent decades, both in terms of food and in terms of the treatment of chronic diseases. Increasing numbers of people are choosing to prevent rather than treat, which is why many consumers are choosing plant-based diets, mainly due to their bioactive compounds. A significant case of bioactive compound is flavonoids—a wide subclass of an even wider class of phytochemicals: polyphenols. Flavonoids are a broad topic of study for researchers due to their potential in the prevention and treatment of a broad range of cancers. The aim of this review is to inform/update the reader on the diversity, accessibility and importance of flavonoids as biomolecules that are essential for optimal health, focusing on the potential of these compounds in the prevention of various types of cancer. Along with conventional sources, this review presents some of the possible methods for obtaining significant amounts of flavonoids based on a slightly different approach, genetic manipulation.

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Section: Flavonoids and Human Healthmentioning

confidence: 99%

Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review

Drețcanu

Ştirbu

Leopold

et al. 2022

Plants

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“…Studies have shown that polyphenols are involved in epigenetic processes that influence the behavior of tumor cells and, not only that, they also are involved in the protection of normal cells by enhancing the cytotoxicity of other therapies in tumor cells [4,54].…”

Section: Modulation Of Gene Expression By Involving Epigenetic Pathwaysmentioning

confidence: 99%

The Involvement of Natural Polyphenols in the Chemoprevention of Cervical Cancer

Drețcanu

Iuhaș

Diaconeasa

2021

IJMS

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From all types of cancer, cervical cancer manages to be in top four most frequent types, with a 6.5% rate of occurrence. The infectious vector that induces the disease, the high-risk Human papillomavirus (HPV), which is a sexually transmitted virus, is capable of transforming the host cell by modulating some of the principal signaling pathways responsible for cell cycle arrest, proliferation, and survival. Fortunately, like other cancer types, cervical cancer can be treated by chirurgical interventions or chemoradiotherapy, but these methods are not exactly the lucky clover of modern medicine because of the adverse effects they have. That is the reason why in the last years the emphasis has been on alternative medicine, more specifically on phytochemicals, as a substantial number of studies showed that diet contributes to cancer prevention and treatment. All these studies are trying to find new chemopreventive agents with less toxicity but high effectiveness both in vitro and in vivo. The aim of this review is to evaluate the literature in order to underline the advantages and disadvantages of polyphenols, a class of dietary compounds, as chemopreventive and chemotherapeutic agents. This review also aims to present polyphenols from different perspectives, starting with mechanisms of action and ending with their toxicity. The bigger picture illustrates that polyphenols have great potential in cervical cancer prevention, with strong effects on gene modulation.

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“…Among the modifiable risk factors of GI tract cancers, diet has been identified as one of the most significant in cancer control. Extensive studies have shown the chemopreventive effect of dietary polyphenols [71,72]. These natural antioxidants can prevent the onset of GI tract cancers, thus enhancing human well-being [73].…”

Section: Esophagealmentioning

confidence: 99%

Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives

Dharmawansa

Hoskin

Rupasinghe

2020

IJMS

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Anthocyanins are a group of dietary polyphenols, abundant mainly in fruits and their products. Dietary interventions of anthocyanins are being studied extensively related to the prevention of gastrointestinal (GI) cancer, among many other chronic disorders. This review summarizes the hereditary and non-hereditary characteristics of GI cancers, chemistry, and bioavailability of anthocyanins, and the most recent findings of anthocyanin in GI cancer prevention through modulating cellular signaling pathways. GI cancer-preventive attributes of anthocyanins are primarily due to their antioxidative, anti-inflammatory, and anti-proliferative properties, and their ability to regulate gene expression and metabolic pathways, as well as induce the apoptosis of cancer cells.

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Cancer Chemoprevention by Dietary Polyphenols

Cited by 5 publications

References 171 publications

Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review

Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review

The Involvement of Natural Polyphenols in the Chemoprevention of Cervical Cancer

Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives

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