Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review

Drețcanu, Georgiana; Ştirbu, Ioana; Leopold, Nicolae; Cruceriu, Daniel; Danciu, Corina; Stănilă, Andreea; Fărcaș, Anca Corina; Borda, Ileana Monica; Iuhaș, Cristian; Diaconeasa, Zorița

doi:10.3390/plants11091117

Cited by 18 publications

(9 citation statements)

References 148 publications

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“…A cohort study conducted by Wang et al reported that the amount of total polyphenols ranged from 8.88 to 47.44 mg/day in the lowest and highest quintile, respectively, among 38,408 middle-aged and old women [ 212 ]. Several studies have shown a correlation between polyphenols-rich diets and a reduced risk of cancer [ 213 , 214 ]. These polyphenols have similar properties in that they can act as antioxidants to scavenge ROS, which triggers pathways leading to cell cycle arrest, apoptosis induction, anti-inflammation, and anti-angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol

et al. 2022

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Growing evidence has been accumulated to show the anticancer effects of daily consumption of polyphenols. These dietary polyphenols include chlorogenic acid, curcumin, epigallocatechin-3-O-gallate, genistein, quercetin, and resveratrol. These polyphenols have similar chemical and biological properties in that they can act as antioxidants and exert the anticancer effects via cell signaling pathways involving their reactive oxygen species (ROS)-scavenging activity. These polyphenols may also act as pro-oxidants under certain conditions, especially at high concentrations. Epigenetic modifications, including dysregulation of noncoding RNAs (ncRNAs) such as microRNAs, long noncoding RNAs, and circular RNAs are now known to be involved in the anticancer effects of polyphenols. These polyphenols can modulate the expression/activity of the component molecules in ROS-scavenger-triggered anticancer pathways (RSTAPs) by increasing the expression of tumor-suppressive ncRNAs and decreasing the expression of oncogenic ncRNAs in general. Multiple ncRNAs are similarly modulated by multiple polyphenols. Many of the targets of ncRNAs affected by these polyphenols are components of RSTAPs. Therefore, ncRNA modulation may enhance the anticancer effects of polyphenols via RSTAPs in an additive or synergistic manner, although other mechanisms may be operating as well.

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Section: Discussionmentioning

confidence: 99%

Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol

et al. 2022

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“…The two aromatic rings A and B, which are joined by the C ring, which contains three carbon atoms, are consisting of fifteen carbon atoms (C6–C3–C6) in the fundamental chemical composition of flavonoids ( Fig. 4 ) [ 46 ]. Several investigations have revealed that flavonoids may defend against a variety of illnesses, including heart disease, cancer, neurological disease, as well as other age-related maladies.…”

Section: What Are Dietary Flavonoids?mentioning

confidence: 99%

Structural insights and shedding light on preferential interactions of dietary flavonoids with G-quadruplex DNA structures: A new horizon

Bag¹,

Burman²,

Bhowmik³

2023

Heliyon

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“…), cereals (black rice, rye, black sorghum, purple barley, red sorghum, etc. ), chocolate, extra virgin olive oil, and beverages like green tea, black tea, red wine, and coffee [ 103 , 104 ].…”

Section: Human Intervention Studies Looking At the Effects Of Foods A...mentioning

confidence: 99%

An Exploratory Critical Review on TNF-α as a Potential Inflammatory Biomarker Responsive to Dietary Intervention with Bioactive Foods and Derived Products

Quarta

Massaro

Carluccio

et al. 2022

Foods

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This review collects and critically examines data on the levels of tumour necrosis factor-alpha (TNF-α) in lean, overweight and obese subjects, and the effects of intervention with different foods and food products containing bioactive constituents in overweight/obese individuals. We additionally explore the influence of different single nucleotide polymorphisms (SNPs) on TNF-α levels and compare the response to food products with that to some anti-obesity drugs. Our aim was to provide an overview of the variability, consistency, and magnitude of the reported effects of dietary factors on TNF-α, and to envisage the reliability of measuring changes in the levels of this cytokine as a biomarker responsive to food intervention in association with the reduction in body weight. Regarding the circulating levels of TNF-α, we report: (i) a large intra-group variability, with most coefficients of variation (CV%) values being ³30% and, in many cases, >100%; (ii) a large between-studies variability, with baseline TNF-α values ranging from <1.0 up to several hundred pg/mL; (iii) highly variable effects of the different dietary approaches with both statistically significant and not significant decreases or increases of the protein, and the absolute effect size varying from <0.1 pg/mL up to ≈50 pg/mL. Within this scenario of variability, it was not possible to discern clear differentiating limits in TNF-α between lean, overweight, and obese individuals or a distinct downregulatory effect on this cytokine by any of the different dietary approaches reviewed, i.e., polyunsaturated fatty acids (PUFAs), Vitamin-D (VitD), mixed (micro)nutrients, (poly)phenols or other phytochemicals. Further, there was not a clear relationship between the TNF-α responses and body weight changes. We found similarities between dietary and pharmacological treatments in terms of variability and limited evidence of the TNF-α response. Different factors that contribute to this variability are discussed and some specific recommendations are proposed to reinforce the need to improve future studies looking at this cytokine as a potential biomarker of response to dietary approaches.

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Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review

Cited by 18 publications

References 148 publications

Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol

Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol

Structural insights and shedding light on preferential interactions of dietary flavonoids with G-quadruplex DNA structures: A new horizon

An Exploratory Critical Review on TNF-α as a Potential Inflammatory Biomarker Responsive to Dietary Intervention with Bioactive Foods and Derived Products

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