Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol

Abstract

Growing evidence has been accumulated to show the anticancer effects of daily consumption of polyphenols. These dietary polyphenols include chlorogenic acid, curcumin, epigallocatechin-3-O-gallate, genistein, quercetin, and resveratrol. These polyphenols have similar chemical and biological properties in that they can act as antioxidants and exert the anticancer effects via cell signaling pathways involving their reactive oxygen species (ROS)-scavenging activity. These polyphenols may also act as pro-oxidants under certain conditions, especially at high concentrations. Epigenetic modifications, including dysregulation of noncoding RNAs (ncRNAs) such as microRNAs, long noncoding RNAs, and circular RNAs are now known to be involved in the anticancer effects of polyphenols. These polyphenols can modulate the expression/activity of the component molecules in ROS-scavenger-triggered anticancer pathways (RSTAPs) by increasing the expression of tumor-suppressive ncRNAs and decreasing the expression of oncogenic ncRNAs in general. Multiple ncRNAs are similarly modulated by multiple polyphenols. Many of the targets of ncRNAs affected by these polyphenols are components of RSTAPs. Therefore, ncRNA modulation may enhance the anticancer effects of polyphenols via RSTAPs in an additive or synergistic manner, although other mechanisms may be operating as well.

Anti-Inflammatory Effects of Dietary Polyphenols through Inhibitory Activity against Metalloproteinases

“…Recent comprehensive review articles have also discussed the role of MMPs in rheumatoid arthritis (RA) and musculoskeletal diseases [10,11]. Our research group has focused on the health effects of dietary polyphenols such as chlorogenic acid (CGA), curcumin (CUR), EGCG, genistein (GEN), quercetin (QUE), and resveratrol (RES) (Figure 1) and published several review articles including recent ones [12,13]. This review provides updated information on effects of these dietary polyphenols on MMPs in relation to their anti-inflammatory effects with mechanistic aspects including evidence from molecular docking studies.…”

“…Recent comprehensive review articles have also discussed the role of MMPs in rheumatoid arthritis (RA) and musculoskeletal diseases [ 10 , 11 ]. Our research group has focused on the health effects of dietary polyphenols such as chlorogenic acid (CGA), curcumin (CUR), EGCG, genistein (GEN), quercetin (QUE), and resveratrol (RES) ( Figure 1 ) and published several review articles including recent ones [ 12 , 13 ].…”

Curcumin Prevents Free Fatty Acid-Induced Lipid Accumulation <i>via</i> Targeting the miR-22-3p/<i>CRLS1</i> Pathway in HepG2 Cells

“…The exact regulatory effect and action mechanism of miR-22-3p in lipid metabolism may differ due to diverse cell types and pathological statuses investigated. Interestingly, miR-22-3p is a common polyphenol-controlled miRNA [Hayakawa et al, 2022]. Previously, we also reported that miR-22-3p was one of the molecular targets of curcumin [Sun et al, 2023].…”

Therapeutic effects of resveratrol on epigenetic mechanisms in age‐related diseases: A comprehensive review

“…Furthermore, epigenetic is one of the most important fields by which RSV exerts its antiaging effects (Pyo et al, 2020b). Affecting noncoding RNAs (e.g., miRNAs and long noncoding RNAs), regulating histone and chromatin changes, and changing DNA methylation status are the main mechanisms by which RSV play its role as an epigenetic modulator and consequent antiaging effects (Hayakawa et al, 2022; Lee et al, 2012; Parrella et al, 2022; Shu et al, 2020; Zadi Heydarabad et al, 2018).…”