Curcumin Prevents Free Fatty Acid-Induced Lipid Accumulation <i>via</i> Targeting the miR-22-3p/<i>CRLS1</i> Pathway in HepG2 Cells
Yuanyuan Mei,
Xiaoting Sun,
Shi-Ying Huang
et al.
Abstract:Dysregulated lipid metabolism in liver is an important hallmark of non-alcoholic fatty liver disease (NAFLD), which may be modulated by dietary polyphenols or microRNAs (miRNAs). However, the underlying epigenetic regulatory mechanism of polyphenols remain unclear. The current study aimed to address how miRNA mediates hepatic lipid metabolic control of curcumin, a polyphenolic food supplement. The results showed that 24 h treatment with 5-20 µM curcumin prevented free fatty acid-induced lipid accumulation by a… Show more
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