Therapeutic effects of resveratrol on epigenetic mechanisms in age‐related diseases: A comprehensive review

Abstract

Recently, various studies have shown that epigenetic changes are associated with aging and age‐related diseases. Both animal and human models have revealed that epigenetic processes are involved in aging mechanisms. These processes happen at multiple levels and include histone modification, DNA methylation, and changes in noncoding RNA expression. Consequently, changes in the organization of chromatin and DNA accessibility lead to the regulation of gene expression. With increasing awareness of the pivotal function of epigenetics in the aging process, researchers' attention has been drawn to how these epigenetic changes can be modified to prevent, stop, or reverse aging, senescence, and age‐related diseases. Among various agents that can affect epigenetic, polyphenols are well‐known phytochemicals found in fruits, vegetables, and plants. Polyphenols are found to modify epigenetic‐related mechanisms in various diseases and conditions, such as metabolic disorders, obesity, neurodegenerative diseases, cancer, and cardiovascular diseases. Resveratrol (RSV) is a member of the stilbene subgroup of polyphenols which is derived from various plants, such as grapes, apples, and blueberries. Therefore, herein, we aim to summarize how RSV affects different epigenetic processes to change aging‐related mechanisms. Furthermore, we discuss its roles in age‐related diseases, such as Alzheimer's, Parkinson's, osteoporosis, and cardiovascular diseases.

Resveratrol is converted to the ring portion of coenzyme Q10 and raises intracellular coenzyme Q10 levels in HepG2 cell

“…Resveratrol (RSV), found in a wide range of plants, has garnered attention as an anti-aging compound. (9) It has been associated with a variety of health-promoting effects and has demonstrated the potential to mitigate various diseases, including diabetes, neurodegeneration, and aging. (10)(11)(12) While the precise mechanisms underlying these functions are still debated, they may be attributed in part to their antioxidant properties and its ability to modulate mitochondrial functions.…”

Special Issue “Ovarian Cancer: Advances on Pathophysiology and Therapies”

“…Finally, Chitcholtan and colleagues evaluated the anticancer effects of resveratrol, a natural compound with several beneficial effects [22][23][24][25], on ovarian cancer cell lines, i.e., OVCAR-8 and SKOV-3, grown on the chorioallantoic membrane (CAM) of chicken embryos. The authors found that resveratrol significantly reduced angiogenic activities, pNF-κB levels, and SLUG protein levels, suggesting that this compound may have the potential to impact the behavior of ovarian cancer progression.…”