Bisphenol A (BPA) is a chemical used in the production of polycarbonate plastic and epoxy resins, which are used in a wide range of products, including plastic bottles, food containers, optical discs, dental fillings, and on the inner coating of cans.1 Therefore, BPA exposure is ubiquitous and has been detected in >95% of the population in the United States.
2BPA shows affinity for the estrogen receptor and may alter its function by blocking or mimicking the action of estrogen.
3Previous epidemiological studies have reported the associations between BPA exposure and adverse health effects on the reproductive 4-8 and endocrine systems. 9 BPA exposure had also been associated with cardiovascular disorders. We had previously reported that increased urinary BPA concentration was associated with higher blood pressure (BP) and decreased heart rate variability (HRV) in a panel study with elderly participants. 10 A previous study that analyzed the National Health and Nutrition Examination Survey data set also reported that increased urinary BPA concentration was associated with hypertension.11 Furthermore, other studies had reported that increased urinary BPA was associated with heart and peripheral artery diseases, of which hypertension and decreased HRV are important risk factors. 9,[12][13][14] Considering that most of the previous epidemiological studies examined the crosssectional associations between urinary BPA concentration and health outcomes, a randomized intervention trial can provide a higher level of evidence and may elucidate the health effect of BPA more clearly.Canned food is one of the known BPA exposure sources. Previous studies have reported that BPA in the epoxy lining of the can containers could leach into food.15-17 A randomized crossover trial showed that eating canned soup for 5 consecutive days increased urinary BPA concentration by >1000% compared with eating soup cooked with fresh ingredients.
18The increase exceeds the range of exposure previously reported to be associated with increased risk of cardiovascular disorders in the previous epidemiological studies. However, we could not find any report on the health effect of such increased exposure caused by consuming canned food.In the present study, we conducted randomized crossover intervention trial to examine whether consuming canned beverage and consequent increase of BPA exposure actually affect BP and HRV.Abstract-Bisphenol A (BPA) is a chemical used in plastic bottles and inner coating of beverage cans, and its exposure is almost ubiquitous. BPA has been associated with hypertension and decreased heart rate variability in the previous studies. The aim of the present study was to determine whether increased BPA exposure from consumption of canned beverage actually affects blood pressure and heart rate variability. We conducted a randomized crossover trial with noninstitutionalized adults, who were aged ≥60 years and recruited from a local community center. A total of 60 participants visited the study site 3 times, and they were provided t...