Insulin signaling and its application

Le, Thi Kim Chung; Dao, Xuan Dat; Nguyen, Dang Vung; Luu, Duc Huy; Bui, Thi Minh Hanh; Le, Thi Huong; Nguyen, Huu Thang; Le, Tran Ngoan; Hosaka, Toshio; Nguyen, Thi Thu Thao

doi:10.3389/fendo.2023.1226655

Cited by 11 publications

(2 citation statements)

References 110 publications

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“…These results could be replicated in vivo , demonstrating the remarkable potential of APS in alleviating thoracic aortic complications in diabetic rats ( 160 ). Moreover, SH2B2 connects with the insulin receptor, promotes robust activation of the insulin signaling pathway, and supports its optimal functionality ( 164 ). In cell cultures, SH2B2 shows a compelling ability to bind to JAK2 via its SH2 domain, resulting in a strong enhancement of JAK2 activation ( 165 ).…”

Section: Astragalus Polysaccharidementioning

confidence: 99%

Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look

Baig,

Barmpoutsi,

Bharti

et al. 2024

Front. Immunol.

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Macrophages play a central role in initiating, maintaining, and terminating inflammation. For that, macrophages respond to various external stimuli in changing environments through signaling pathways that are tightly regulated and interconnected. This process involves, among others, autoregulatory loops that activate and deactivate macrophages through various cytokines, stimulants, and other chemical mediators. Adaptor proteins play an indispensable role in facilitating various inflammatory signals. These proteins are dynamic and flexible modulators of immune cell signaling and act as molecular bridges between cell surface receptors and intracellular effector molecules. They are involved in regulating physiological inflammation and also contribute significantly to the development of chronic inflammatory processes. This is at least partly due to their involvement in the activation and deactivation of macrophages, leading to changes in the macrophages’ activation/phenotype. This review provides a comprehensive overview of the 20 adaptor molecules and proteins that act as negative regulators of inflammation in macrophages and effectively suppress inflammatory signaling pathways. We emphasize the functional role of adaptors in signal transduction in macrophages and their influence on the phenotypic transition of macrophages from pro-inflammatory M1-like states to anti-inflammatory M2-like phenotypes. This endeavor mainly aims at highlighting and orchestrating the intricate dynamics of adaptor molecules by elucidating the associated key roles along with respective domains and opening avenues for therapeutic and investigative purposes in clinical practice.

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Section: Astragalus Polysaccharidementioning

confidence: 99%

Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look

Baig,

Barmpoutsi,

Bharti

et al. 2024

Front. Immunol.

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“…This work is currently being conducted and put into practice[ 16 ]. Research has investigated the relationship between IR and the development of cardiometabolic disorders[ 17 , 18 ]. Realistic therapeutic targets were identified after a thorough analysis of insulin signaling and IR mechanisms[ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Mapping the global research landscape on nonalcoholic fatty liver disease and insulin resistance: A visualization and bibliometric study

Zyoud,

Hegazi,

Alalalmeh

et al. 2024

World J Hepatol

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BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is a liver condition that is prevalent worldwide and associated with significant health risks and economic burdens. As it has been linked to insulin resistance (IR), this study aimed to perform a bibliometric analysis and visually represent the scientific literature on IR and NAFLD. AIM To map the research landscape to underscore critical areas of focus, influential studies, and future directions of NAFLD and IR. METHODS This study conducted a bibliometric analysis of the literature on IR and NAFLD indexed in the SciVerse Scopus database from 1999 to 2022. The search strategy used terms from the literature and medical subject headings, focusing on terms related to IR and NAFLD. VOSviewer software was used to visualize research trends, collaborations, and key thematic areas. The analysis examined publication type, annual research output, contributing countries and institutions, funding agencies, journal impact factors, citation patterns, and highly cited references. RESULTS This analysis identified 23124 documents on NAFLD, revealing a significant increase in the number of publications between 1999 and 2022. The search retrieved 715 papers on IR and NAFLD, including 573 (80.14%) articles and 88 (12.31%) reviews. The most productive countries were China (n = 134; 18.74%), the United States (n = 122; 17.06%), Italy (n = 97; 13.57%), and Japan (n = 41; 5.73%). The leading institutions included the Università degli Studi di Torino, Italy (n = 29; 4.06%), and the Consiglio Nazionale delle Ricerche, Italy (n = 19; 2.66%). The top funding agencies were the National Institute of Diabetes and Digestive and Kidney Diseases in the United States (n = 48; 6.71%), and the National Natural Science Foundation of China (n = 37; 5.17%). The most active journals in this field were Hepatology (27 publications), the Journal of Hepatology (17 publications), and the Journal of Clinical Endocrinology and Metabolism (13 publications). The main research hotspots were “therapeutic approaches for IR and NAFLD” and “inflammatory and high-fat diet impacts on NAFLD”. CONCLUSION This is the first bibliometric analysis to examine the relationship between IR and NAFLD. In response to the escalating global health challenge of NAFLD, this research highlights an urgent need for a better understanding of this condition and for the development of intervention strategies. Policymakers need to prioritize and address the increasing prevalence of NAFLD.

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The cellular and molecular targets of natural products against metabolic disorders: a translational approach to reach the bedside

Shen,

Yang,

Yang

et al. 2024

MedComm

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Metabolic disorders, including obesity, dyslipidemia, diabetes, nonalcoholic fatty liver disease, and metabolic syndrome, are characterized by insulin resistance, abnormalities in circulating cholesterol and lipid profiles, and hypertension. The most common pathophysiologies of metabolic disorders are glucose/lipid metabolism dysregulation, insulin resistance, inflammatory response, and oxidative stress. Although several agents have been approved for the treatment of metabolic disorders, there is still a strong demand for more efficacious drugs with less side effects. Natural products have been critical sources of drug research and discovery for decades. However, the usefulness of bioactive natural products is often limited by incomplete understanding of their direct cellular targets. In this review, we highlight the current understanding of the established and emerging molecular mechanisms of metabolic disorders. We further summarize the therapeutic effects and underlying mechanisms of natural products on metabolic disorders, with highlights on their direct cellular targets, which are mainly implicated in the regulation of glucose/lipid metabolism, insulin resistance, metabolic inflammation, and oxidative stress. Finally, this review also covers the clinical studies of natural products in metabolic disorders. These progresses are expected to facilitate the application of these natural products and their derivatives in the development of novel drugs against metabolic disorders.

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Insulin signaling and its application

Cited by 11 publications

References 110 publications

Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look

Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look

Mapping the global research landscape on nonalcoholic fatty liver disease and insulin resistance: A visualization and bibliometric study

The cellular and molecular targets of natural products against metabolic disorders: a translational approach to reach the bedside

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