The cellular and molecular targets of natural products against metabolic disorders: a translational approach to reach the bedside
Xiaofei Shen,
Hongling Yang,
Yang Yang
et al.
Abstract:Metabolic disorders, including obesity, dyslipidemia, diabetes, nonalcoholic fatty liver disease, and metabolic syndrome, are characterized by insulin resistance, abnormalities in circulating cholesterol and lipid profiles, and hypertension. The most common pathophysiologies of metabolic disorders are glucose/lipid metabolism dysregulation, insulin resistance, inflammatory response, and oxidative stress. Although several agents have been approved for the treatment of metabolic disorders, there is still a stron… Show more
Provided herein are novel heteroaryl fluoroalkenes as DGK inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, particularly metastatic melanoma, and processes for preparing such compounds.
Important Compound Classes.
Provided herein are novel heteroaryl fluoroalkenes as DGK inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, particularly metastatic melanoma, and processes for preparing such compounds.
Important Compound Classes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.